Results 41 to 50 of about 1,104,579 (208)

Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used.
Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira   +5 more
doaj   +1 more source

Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells.

Frontiers in Immunology, 2016
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity and long-term maintenance of tolerance.
Robert eHilbrands, Ye eChen, Adrian eKendal, Elizabeth eAdams, Stephen Paul Cobbold, Herman eWaldmann, Duncan eHowie   +6 more
doaj   +1 more source

Autologous fecal transplantation from a lean state potentiates caloric restriction effects on body weight and adiposity in obese mice

Scientific Reports, 2020
Autologous fecal transplantation (FT-A) emerges as a promising strategy to modulate gut microbiota with minimal side effects since individual´s own feces are transplanted.
P. Pérez-Matute, M. Íñiguez, María de Toro, E. Recio-Fernández, J. Oteo   +4 more
semanticscholar   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

Tumor Transplantation to the Subdural Space of Heterologous Hosts.

Experimental Biology and Medicine, 1951
SummaryMouse Sarcoma 37 was transplanted to the subdural space of 14 guinea pigs. Evidence of growth was present in all animals sacrificed between the 2nd and 18th day after transplantation. One animal died at the end of the third week, apparently as the result of invasion of the brain by tumor tissue.
H. Y. Chang, G. J. Goodman, E. J. Eichwald   +2 more
openaire   +3 more sources

Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases

Advanced Science, EarlyView.
Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang, Sen Yang, Xiaomi Wang, Yuanwei Zhang, Yao Zhao, Menghuan Tao, Jinyi Zhu, Wanxin Zhang, Yansu Wang, Kaixuan Duan, Yan Wang, Wenwu Ye, Zhenfei Guo, Yuanchao Wang   +13 more
wiley   +1 more source

Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation

mBio, 2016
Bacterial communities from subjects treated for recurrent Clostridium difficile infection (rCDI) by fecal microbiota transplantation (FMT), using either heterologous donor stool samples or autologous stool samples, were characterized by Illumina next ...
Christopher Staley, Colleen R. Kelly, Lawrence J. Brandt, Alexander Khoruts, Michael J. Sadowsky   +4 more
doaj   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Human islet xenotransplantation in rodents: A literature review of experimental model trends

Clinics
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto, André Silva Franco, Fábio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Juliana Mika Kato, Matheus Belloni Torsani, Alberto Meyer, Wellington Andraus, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque   +10 more
doaj   +1 more source