Results 51 to 60 of about 1,104,579 (208)

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

Frontiers in Immunology, 2018
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots   +12 more
doaj   +1 more source

Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses

Frontiers in Cell and Developmental Biology, 2023
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder specifically targeting pancreatic islet beta cells. Despite many efforts focused on identifying new therapies able to counteract this autoimmune attack and/or stimulate beta cells regeneration ...
C. C. Lachaud, N. Cobo-Vuilleumier, E. Fuente-Martin, I. Diaz, E. Andreu, E. Andreu, G. M. Cahuana, G. M. Cahuana, J. R. Tejedo, J. R. Tejedo, A. Hmadcha, A. Hmadcha, B. R. Gauthier, B. R. Gauthier, B. Soria, B. Soria, B. Soria   +16 more
doaj   +1 more source

Synthetic Biology‐Based Engineering Living Therapeutics for Antimicrobial Application

Exploration, EarlyView.
This perspective highlights synthetic biology‐driven antibacterial strategies, focusing on three innovative approaches: engineered bacteriophages for precision bacterial targeting, reprogrammed microbes that detect quorum‐sensing signals or metabolites to release antimicrobials, and engineering mammalian cells that recognize pathogen‐associated ...
Shun Huang, Shuihao Zhao, Haijie Zhao, Mingzhang Wen, Zhong Guo   +4 more
wiley   +1 more source

HETEROLOGOUS TRANSPLANTATION OF BOVINE ETHMOID CARCINOMA CELLS USING CYCLOSPORINE-A [PDF]

Journal of Veterinary and Animal Sciences, 2006
A study was undertaken to transplant bovine ethmoid tumour cells into different heterologous species of animals using CS-A. Transplanted tumours offer an excellent model system for evaluating immunoprophylactic measures, chemo-sensitivity and tumour ...
Ajith Jacob George, K.M. Ramachandran, A. Rajan, K.T. Punnoose, C.B. Manomohan   +4 more
doaj  

Heterodigital flap as a solution for a thumb defect: a case report [PDF]

Journal of Trauma and Injury
Thumb traumatic injuries are incredibly common in hand injuries. The thumb is essential to hand function in order to do daily tasks like gripping, holding, opposing, circumducting, and movements.
Bontor Daniel Sinaga, Dwi Purnomo Setyo Budi, Mochamad Sadabaskara   +2 more
doaj   +1 more source

Teratoid Hepatoblastoma: Clinicopathologic Features and Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Teratoid hepatoblastoma (HB) is a rare histologic subtype of the most common pediatric liver cancer. Understanding of the clinicopathologic features and outcomes of patients with this disease is currently limited. Methods Multi‐institution, retrospective chart review was conducted to compare 20 children with teratoid HB to 129 ...
Brian T. Hickner, Andres F. Espinoza, Soo Jin Cho, Stephen Sarabia, Martin Urbicain, Ann Wang, Sanjeev A. Vasudevan, Dolores H. López‐Terrada, Kalyani R. Patel   +8 more
wiley   +1 more source

Ultrastructural Cytochemistry of Acetylcholinesterase Enzyme Activity in Pancreatic Tissue Transplants in Rats

Cell Transplantation, 1994
The distribution of acetylcholinesterase (AChE) at the ultrastructural level was investigated in normal and in pancreatic fragments transplanted for 56 days into the anterior eye chamber of heterologous rats using enzyme cytochemical methods ...
Ernest Adeghate, Tibor Donáth
doaj   +1 more source

Heterogeneity within T Cell Memory: Implications for Transplant Tolerance

Frontiers in Immunology, 2012
Adaptive immunity in both mouse and man results in the generation of immunological memory. Memory T cells are both friend and foe to transplant recipients, as they are intimately involved and in many cases absolutely required for the maintenance of ...
Scott M. Krummey, Mandy L Ford
doaj   +1 more source

Open Questions in Surgery for Hepatoblastoma: A Joined SIOPEL‐IPSO Survey

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Surgery is pivotal in the management of hepatoblastoma (HB) although approaches and techniques may vary. The Liver Group of the International Society of Pediatric Oncology (SIOPEL) and the International Pediatric Surgical Oncology (IPSO) group collaborated to develop an online survey to investigate specific technical aspects and ...
Chiara Grimaldi, Francesca Gigola, Reto M. Baertschiger, Marco Del Riccio, Hanna Garnier, Gloria Gonzalez, York Tien Lee, Amos Loh, Luca Pio, Sophie Branchereau   +9 more
wiley   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source