Results 51 to 60 of about 1,142,920 (273)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Heterogeneity within T Cell Memory: Implications for Transplant Tolerance

Frontiers in Immunology, 2012
Adaptive immunity in both mouse and man results in the generation of immunological memory. Memory T cells are both friend and foe to transplant recipients, as they are intimately involved and in many cases absolutely required for the maintenance of ...
Scott M. Krummey, Mandy L Ford
doaj   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Human islet xenotransplantation in rodents: A literature review of experimental model trends

Clinics
Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low
Leandro Ryuchi Iuamoto, André Silva Franco, Fábio Yuji Suguita, Felipe Futema Essu, Lucas Torres Oliveira, Juliana Mika Kato, Matheus Belloni Torsani, Alberto Meyer, Wellington Andraus, Eleazar Chaib, Luiz Augusto Carneiro D’Albuquerque   +10 more
doaj   +1 more source

HETEROLOGOUS TRANSPLANTATION OF BOVINE ETHMOID CARCINOMA CELLS USING CYCLOSPORINE-A [PDF]

Journal of Veterinary and Animal Sciences, 2006
A study was undertaken to transplant bovine ethmoid tumour cells into different heterologous species of animals using CS-A. Transplanted tumours offer an excellent model system for evaluating immunoprophylactic measures, chemo-sensitivity and tumour ...
Ajith Jacob George, K.M. Ramachandran, A. Rajan, K.T. Punnoose, C.B. Manomohan   +4 more
doaj  

Heterodigital flap as a solution for a thumb defect: a case report [PDF]

Journal of Trauma and Injury
Thumb traumatic injuries are incredibly common in hand injuries. The thumb is essential to hand function in order to do daily tasks like gripping, holding, opposing, circumducting, and movements.
Bontor Daniel Sinaga, Dwi Purnomo Setyo Budi, Mochamad Sadabaskara   +2 more
doaj   +1 more source

Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses

Frontiers in Cell and Developmental Biology, 2023
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder specifically targeting pancreatic islet beta cells. Despite many efforts focused on identifying new therapies able to counteract this autoimmune attack and/or stimulate beta cells regeneration ...
C. C. Lachaud, N. Cobo-Vuilleumier, E. Fuente-Martin, I. Diaz, E. Andreu, E. Andreu, G. M. Cahuana, G. M. Cahuana, J. R. Tejedo, J. R. Tejedo, A. Hmadcha, A. Hmadcha, B. R. Gauthier, B. R. Gauthier, B. Soria, B. Soria, B. Soria   +16 more
doaj   +1 more source

Antibody localization in horse, rabbit, and goat antilymphocyte sera [PDF]

, 1970
The localization of antibodies was studied in rabbit, goat, and horse ALS raised by weekly immunization with canine or human spleen cells for 4 to 12 weeks.
Jacobs, R, Kapur, B, Kashiwagi, N, Ono, K, Sherer, D, Starzl, TE, Townsend, CM   +6 more
core  

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

Frontiers in Immunology, 2018
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots   +12 more
doaj   +1 more source