Results 31 to 40 of about 1,475 (161)
Stem Cells International, Volume 2015, Issue 1, 2015., 2015 Application of mesenchymal stromal cells (MSC) has been proposed for solid organ transplantation based on their potent immunomodulatory effects. Since side effects from the injection of large cells cannot be excluded, the hypothesis rises that extracellular vesicles (EV) may cause immunomodulatory effects comparable to MSC without additional side ...
M. Koch, A. Lemke, C. Lange, Eva Mezey
wiley +1 more source
Two Faces of TGF‐Beta1 in Breast Cancer
Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014 Breast cancer (BC) is potentially life‐threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF‐β1 is one of many factors that have
Joanna Magdalena Zarzynska +1 more
wiley +1 more source
Immunological Barriers to Stem Cell Therapy in the Central Nervous System
Stem Cells International, Volume 2014, Issue 1, 2014., 2014 The central nervous system is vulnerable to many neurodegenerative disorders such as Alzheimer’s disease that result in the extensive loss of neuronal cells. Stem cells have the ability to differentiate into many types of cells, which make them ideal for treating such disorders.
Gregory E. Tullis +3 more
wiley +1 more source
Islet Assessment for Transplantation [PDF]
, 2009 Author Manuscript: 2010 December 1.Purpose of review: There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation (ICT).
Colton, Clark K. +2 more
core +1 more source
International Journal of Endocrinology, Volume 2012, Issue 1, 2012., 2012 The complementary role of hyperglycemia and p27kip1 suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27kip1 gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27kip1 protein content in cultured targeting islets was 22% of that in ...
Szu-Tah Chen +5 more
wiley +1 more source
Cell Transplantation, 1996 Intraductal distention of the pancreas with collagenase followed by stationary warm incubation improves the recovery of islets of Langerhans in the rat, but controlled studies are needed for valid comparison with standard isolation methods.
A.M. James Shapiro +3 more
doaj +1 more source
Initial Inhibition of Tissue Factor Signalling Reduces Chronic Vascular Changes in Isogenic Rat Aortic Transplants [PDF]
American Journal of Transplantation, 2001 Vascular changes are considered the major histopathological indicator of chronic allograft dysfunction. These changes are characterized by intimal thickening caused by accumulation of primarily smooth muscle cells. Contributing factors may be of both immunological and nonimmunological origin.
C, Osterholm +6 more
openaire +2 more sources
Osteogenic Small Molecule FK506 for Enhanced Bone Formation in a Rabbit Ankle Fusion Model
Journal of Orthopaedic Research, Volume 43, Issue 10, Page 1805-1812, October 2025.ABSTRACT Non‐union remains a significant complication following ankle fusion procedures, underscoring the need for effective osteogenic adjuvants to improve boney healing and fusion outcomes. This study investigates the osteogenic potential of FK506 (Tacrolimus), both in vitro and in vivo, for enhanced ankle fusion.
Nicholas Huffman +6 more
wiley +1 more source
Advanced Science, Volume 12, Issue 20, May 29, 2025.Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu +19 more
wiley +1 more source
A novel variant in the FLCN gene in a Chinese family with Birt–Hogg–Dubé syndrome
Molecular Genetics &Genomic Medicine, Volume 12, Issue 7, July 2024.In a BHD‐associated renal tumors Chinese family. A novel heterozygous variant (NM_144997.5:c.977dup) was identified in exon 9 of the FLCN gene, which broadens the spectrum of FLCN variants. We recommend that molecular analysis of the FLCN gene be performed in patients with suspected BHDS and their families.
He Miao +6 more
wiley +1 more source