Results 51 to 60 of about 1,247,898 (402)
Immunology of skin transplantation
Clinics in Dermatology, 2005 Untreated viable allogeneic skin is highly immunogenic. Epidermal Langerhans migrate after transplantation out of the donor skin into the lymph node of the recipient where they can activate T cells capable to mediate rejection. Allogeneic skin is used as a temporary coverage of burn wounds, often in combination with autologous skin grafts.
Richters, C.D. +4 more
openaire +4 more sources
JCI Insight, 2021 The aryl-hydrocarbon receptor (AHR) is an intracellular sensor of aromatic hydrocarbons that sits at the top of various immunomodulatory pathways. Here, we present evidence that AHR plays a role in controlling IL-17 responses and the development of ...
Stephen J. Gurczynski +5 more
doaj +1 more source
On the crossroad between tolerance and posttransplant lymphoma. [PDF]
, 1997 The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core +1 more source
JCI Insight, 2020 Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell transcriptomics to dissect the contribution of myeloid cell subsets and their potential signaling ...
Anil Dangi +8 more
doaj +1 more source
Imaging alloreactive T cells provides early warning of organ transplant rejection
JCI Insight, 2021 Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. Immune molecular monitoring is under investigation to screen for rejection, though these techniques have suffered from low ...
Toshihito Hirai +11 more
doaj +1 more source
Hilliard Seigler, M.D. and the origins of kidney transplantation and immunology at Duke
Frontiers in Transplantation, 2023 The contributions of Dr. Hilliard Seigler to the founding of the Duke kidney transplantation program were considerable in both surgery and immunology. Some of these highlights are summarized based upon interviews with Dr. Seigler by the authors.
Stuart J. Knechtle, Justin Barr
doaj +1 more source
A predictive model for kidney transplant graft survival using machine learning [PDF]
4th International Conference on Computer Science and Information
Technology (COMIT 2020), November 28-29, 2020, Dubai, UAE. ISBN:
978-1-925953-30-5. Volume 10, Number 16, 2020 Kidney transplantation is the best treatment for end-stage renal failure patients. The predominant method used for kidney quality assessment is the Cox regression-based, kidney donor risk index. A machine learning method may provide improved prediction of transplant outcomes and help decision-making. A popular tree-based machine learning method, random
arxiv +1 more source
The Journal of Clinical Investigation, 2022 Graft-versus-host disease (GVHD), manifesting as either acute (aGVHD) or chronic (cGVHD), presents significant life-threatening complications following allogeneic hematopoietic cell transplantation. Here, we investigated Friend virus leukemia integration
Steven D. Schutt +14 more
doaj +1 more source
Development of heterotopic transplantation of the testis with the epididymis to evaluate an aspect of testicular immunology in rats. [PDF]
PLoS ONE, 2017 Transplantation of testicular cells and tissues has been studied for the investigation of immunology of the testis, which is an immunologically privileged organ.
Kai Yi +8 more
doaj +1 more source
The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease
JCI Insight, 2023 Gastrointestinal graft-versus-host disease (GvHD) is a major cause of mortality and morbidity following allogeneic bone marrow transplantation (allo-BMT).
Erica Dander +19 more
doaj +1 more source