Results 61 to 70 of about 5,891 (253)

LINFOMA PRIMÁRIO DE SISTEMA NERVOSO CENTRAL: UM RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: O linfoma primário de sistema nervoso central (LPSNC) é um linfoma não-Hodgkin extranodal restrito ao parênquima cerebral, meninges, medula espinhal, líquido cefalorraquidiano e/ou olhos. Cerca de 90% dos casos são linfomas difusos de grandes
FF Camargo, ET Saito, ABD Manduca, JA Gomes, LQ Marques, DSC Filho, AP Graça, FM Marques, DAG Eguez, LLM Perobelli   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

RELATO DE CASO: LEUCEMIA MIELOIDE AGUDA MEGACARIOBLÁSTICA COM CARIÓTIPO COMPLEXO EM PACIENTE IDOSA

Hematology, Transfusion and Cell Therapy
Introdução: A leucemia mieloide aguda megacarioblástica (LMA-M7) é uma forma rara de leucemia caracterizada pela proliferação clonal de megacariócitos imaturos.
DSC Filho, LQ Marques, JA Gomes, FM Marques, MDS Pastori, KP Melillo, ET Saito, ABD Manduca, FF Camargo, LLM Perobelli   +9 more
doaj   +1 more source

Aplicação de instrumentos de qualidade em doação de órgãos e transplantes da Espanha validados em hospitais pilotos em Santa Catarina

Brazilian Journal of Nephrology, 2015
ResumoIntrodução:A necessidade de aumentar o número de notificações de potenciais doadores e de doadores efetivos é um problema mundial. Ainda há muitas perdas de doadores, as quais podem ser evitadas.Objetivo:Utilizar os instrumentos adaptados do Modelo
Neide da Silva Knihs, Bartira de Aguiar Roza, Janine Schirmer, Agenor Spallini Ferraz   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Três anos de ventriculectomia parcial esquerda: resultados globais e tardios em 41 pacientes

Brazilian Journal of Cardiovascular Surgery, 1999
Objetivos: Avaliar a indicação, sobrevida, qualidade de vida e arritmias após Ventriculectomia Parcial Esquerda (VPE) e relatar seu uso como ponte para transplante.
José Dario FROTA FILHO, Fernando A. LUCCHESE, Celso BLACHER, Cídio HALPERIN, José JAWETZ, Eraldo A. LÚCIO, Wagner PEREIRA, Mario VALLENAS, Luis E. VARGAS, Ralf STUERMER, Paulo LEÃES   +10 more
doaj  

Producción científica española en el campo de los transplantes: 1990-1996

Revista Española de Documentación Científica, 1999
Este estudio bibliométrico intenta dar a conocer la situación que recientemente ha atravesado la investigación española en el campo de los transplantes tanto a nivel nacional como internacional, particularmente en este último.
Elisa Prieto Castro, Marcos Antonio Catalán Vega   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source