Results 81 to 90 of about 5,891 (253)

Complemento y transplantes

, 2015
El sistema de complemento, es un sistema funcional de más de 30 proteínas séricas, que interaccionan entre sí de modo regulado formando una cascada enzimática, permitiendo una amplificación de la respuesta humoral.
Chuluyan, Hector Eduardo, Guerrieri, Diego, Caro, Fiorella Yanina, Sanchez, Francisco, Sanchez, Mercedes Leonor, Ambrosi, Nella Gabriela   +5 more
core   +1 more source

COEXISTÊNCIA DE NEOPLASIA MIELOPROLIFERATIVA E LINFOPROLIFERATIVA

Hematology, Transfusion and Cell Therapy
Introdução: As neoplasias mieloproliferativas crônicas (NMP) são distúrbios clonais das células hematopoéticas caracterizadas pela proliferação de uma ou mais das linhagens mieloides.
ET Saito, FF Camargo, ABD Manduca, DSC Filho, LQ Marques, VL Aldred, JA Gomes, MDS Pastorini, JO Martins, LLM Perobelli   +9 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

LINFOMA DE CÉLULAS T/NK EXTRANODAL TESTICULAR: RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: O linfoma de células T/NK extranodal testicular, é uma doença rara, de comportamento clínico agressivo derivado de células natural-killer ou, mais raramente, de linfócitos T citotóxicos.
FF Camargo, ET Saito, ABD Manduca, JA Gomes, LQ Marques, DSC Filho, MDS Pastori, MJFS Junior, DAG Eguez, LLM Perobelli   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Transplante hepático na perspectiva da bioética: um estudo de caso [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, Florianópolis, 2014.O transplante de órgãos e tecidos está consolidado mundialmente como recurso terapêutico utilizado ...
Ferrazzo, Sílvia
core  

USO DE RUXOLITINIB PRE TRANSPLANTE DE MEDULA ÓSSEA EM MIELOFIBROSE PRIMARIA - EXPERIÊNCIA DE UMA INSTITUIÇÃO PÚBLICA BRASILEIRA

Hematology, Transfusion and Cell Therapy, 2020
M.C.G. Assis, D.A.G. Eguez, A.L. Stollenwerk, A.P. Graça, M.J.F.S. Junior, R.F.M. Nunes, R.M.A. Passos, F.M. Marques, E.X. Souto, L.L.M. Perobelli   +9 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source