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An international questionnaire highlights and supports the case for including girls in Creatine Transporter Deficiency research [PDF]

Frontiers in Neuroscience
Over the last 15 years, significant progress has been made for Creatine Transporter Deficiency (CTD) patients, with increased awareness and visibility, better diagnosis, and improved care.
Carole Chehowah, Carole Chehowah, Audrey Mittelman, Vincent des Portes   +3 more
doaj   +2 more sources

Investigating the Properties of ABS-Based Plastic Composites Manufactured by Composite Plastic Manufacturing

Journal of Manufacturing and Materials Processing, 2022
Additive manufacturing (AM) technologies have revolutionized the manufacturing sector due to their benefits, such as design flexibility, ease of operation, and wide material selection.
Raghunath Bhaskar, Javaid Butt, Hassan Shirvani   +2 more
doaj   +1 more source

Mechanistic in vitro studies indicate that the clinical drug–drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3

Pharmacology Research & Perspectives, 2023
Previous use of a mechanistic static model to accurately quantify the increased rosuvastatin exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted the magnitude of area under the plasma concentration–time curve ratio ...
Robert Elsby, Hannah Coghlan, Jacob Edgerton, David Hodgson, Samuel Outteridge, Hayley Atkinson   +5 more
doaj   +1 more source

Quantitative phase microscopy for non-invasive live cell population monitoring

Scientific Reports, 2021
We present here a label-free development based on preexisting Quantitative Phase Imaging (QPI) that allows non-invasive live monitoring of both individual cells and cell populations.
Sherazade Aknoun, Manuel Yonnet, Zied Djabari, Fanny Graslin, Mark Taylor, Thierry Pourcher, Benoit Wattellier, Philippe Pognonec   +7 more
doaj   +1 more source

Metabolome of Cerebral Thrombi Reveals an Association between High Glycemia at Stroke Onset and Good Clinical Outcome

Metabolites, 2020
Despite the fact that glucose is the main fuel of the brain, hyperglycemia at hospital admission is generally associated with a poor functional outcome in stroke patients.
Laurent Suissa, Jean-Marie Guigonis, Fanny Graslin, Emilie Doche, Ophélie Osman, Yves Chau, Jacques Sedat, Sabine Lindenthal, Thierry Pourcher   +8 more
doaj   +1 more source

Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection

eLife, 2021
Glia modulate neuronal excitability and seizure sensitivity by maintaining potassium and water homeostasis. A salt inducible kinase 3 (SIK3)-regulated gene expression program controls the glial capacity to buffer K+ and water in Drosophila, however ...
Hailun Li, Lorenzo Lones, Aaron DiAntonio   +2 more
doaj   +1 more source

Genome and Evolutionary Analysis of Nosema ceranae: A Microsporidian Parasite of Honey Bees

Frontiers in Microbiology, 2021
Microsporidia comprise a phylum of single cell, intracellular parasites and represent the earliest diverging branch in the fungal kingdom. The microsporidian parasite Nosema ceranae primarily infects honey bee gut epithelial cells, leading to impaired ...
Qiang Huang, Qiang Huang, Zhi Hao Wu, Zhi Hao Wu, Wen Feng Li, Rui Guo, Jin Shan Xu, Xiao Qun Dang, Zheng Gang Ma, Yan Ping Chen, Jay D. Evans   +10 more
doaj   +1 more source

The Staphylococcus aureus CidA and LrgA Proteins Are Functional Holins Involved in the Transport of By-Products of Carbohydrate Metabolism

mBio, 2022
The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD).
Jennifer L. Endres, Sujata S. Chaudhari, Xinyan Zhang, Janani Prahlad, Shu-Qi Wang, Lily A. Foley, Sorin Luca, Jeffrey L. Bose, Vinai C. Thomas, Kenneth W. Bayles   +9 more
doaj   +1 more source

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Nature Communications, 2018
Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for ...
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker, Renae M Ryan   +4 more
doaj   +1 more source

Evidence for Active Uptake and Deposition of Si-based Defenses in Tall Fescue

Frontiers in Plant Science, 2017
Silicon (Si) is taken up from the soil as monosilicic acid by plant roots, transported to leaves and deposited as phytoliths, amorphous silica (SiO2) bodies, which are a key component of anti-herbivore defense in grasses.
Emma McLarnon, Simon McQueen-Mason, Ingo Lenk, Susan E. Hartley   +3 more
doaj   +1 more source