Results 1 to 10 of about 981,318 (341)

Investigating the Properties of ABS-Based Plastic Composites Manufactured by Composite Plastic Manufacturing

Journal of Manufacturing and Materials Processing, 2022
Additive manufacturing (AM) technologies have revolutionized the manufacturing sector due to their benefits, such as design flexibility, ease of operation, and wide material selection.
Raghunath Bhaskar, Javaid Butt, Hassan Shirvani   +2 more
doaj   +1 more source

Mechanistic in vitro studies indicate that the clinical drug–drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3

Pharmacology Research & Perspectives, 2023
Previous use of a mechanistic static model to accurately quantify the increased rosuvastatin exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted the magnitude of area under the plasma concentration–time curve ratio ...
Robert Elsby, Hannah Coghlan, Jacob Edgerton, David Hodgson, Samuel Outteridge, Hayley Atkinson   +5 more
doaj   +1 more source

Quantitative phase microscopy for non-invasive live cell population monitoring

Scientific Reports, 2021
We present here a label-free development based on preexisting Quantitative Phase Imaging (QPI) that allows non-invasive live monitoring of both individual cells and cell populations.
Sherazade Aknoun, Manuel Yonnet, Zied Djabari, Fanny Graslin, Mark Taylor, Thierry Pourcher, Benoit Wattellier, Philippe Pognonec   +7 more
doaj   +1 more source

Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection

eLife, 2021
Glia modulate neuronal excitability and seizure sensitivity by maintaining potassium and water homeostasis. A salt inducible kinase 3 (SIK3)-regulated gene expression program controls the glial capacity to buffer K+ and water in Drosophila, however ...
Hailun Li, Lorenzo Lones, Aaron DiAntonio   +2 more
doaj   +1 more source

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari, A AntonySunil, A Makino, A Turano, Anindita Das, AO Phillips, B Ashokkumar, B Dutta, B Sihag, BR Chamberlain, CME Tallaksen, Daniel Zehnder, ED Schleicher, Fang Zhang, G Gastaldi, GLJ Page, Guerman Molostvov, H Lum, H Smithline, HM Said, I Hubatsch, J Rieck, James R. Larkin, JC Reidling, JC Reidling, JC Reidling, JD Eudy, KA Robinson, Lisa Godfrey, MJ Boulware, MJ Ryan, MW Pfaffl, N Rabbani, N Rabbani, N Takahashi, N Tasevska, Naila Rabbani, Paul J. Thornalley, PJ Thornalley, R Babaei-Jadidi, S Sander, SM Nabokina, VS Subramanian   +42 more
core   +10 more sources

Metabolome of Cerebral Thrombi Reveals an Association between High Glycemia at Stroke Onset and Good Clinical Outcome

Metabolites, 2020
Despite the fact that glucose is the main fuel of the brain, hyperglycemia at hospital admission is generally associated with a poor functional outcome in stroke patients.
Laurent Suissa, Jean-Marie Guigonis, Fanny Graslin, Emilie Doche, Ophélie Osman, Yves Chau, Jacques Sedat, Sabine Lindenthal, Thierry Pourcher   +8 more
doaj   +1 more source

Genome and Evolutionary Analysis of Nosema ceranae: A Microsporidian Parasite of Honey Bees

Frontiers in Microbiology, 2021
Microsporidia comprise a phylum of single cell, intracellular parasites and represent the earliest diverging branch in the fungal kingdom. The microsporidian parasite Nosema ceranae primarily infects honey bee gut epithelial cells, leading to impaired ...
Qiang Huang, Qiang Huang, Zhi Hao Wu, Zhi Hao Wu, Wen Feng Li, Rui Guo, Jin Shan Xu, Xiao Qun Dang, Zheng Gang Ma, Yan Ping Chen, Jay D. Evans   +10 more
doaj   +1 more source

Extracellular Production of Glutathione by Recombinant Escherichia coli K-12

Microbiology Research, 2023
The goal of this study was to produce a sufficient amount of glutathione in the fermentation medium without the addition of cysteine. This would simplify and reduce the cost of its purification.
Hideyuki Suzuki, Kazuki Nishida, Tatsuya Nakamura   +2 more
doaj   +1 more source

Untargeted Metabolomics Uncovers the Essential Lysine Transporter in Toxoplasma gondii

Metabolites, 2021
Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, and cryptosporidiosis. Current treatments are limited by emerging resistance to, as well as the high cost and toxicity of existing drugs.
Joachim Kloehn, Matteo Lunghi, Emmanuel Varesio, David Dubois, Dominique Soldati-Favre   +4 more
doaj   +1 more source

An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development [PDF]

, 2010
FLOWER FLAVONOID TRANSPORTER (FFT) encodes a multidrug and toxin efflux family transporter in Arabidopsis thaliana. FFT (AtDTX35) is highly transcribed in floral tissues, the transcript being localized to epidermal guard cells, including those of the ...
Aarts, Beverley J. Glover, Blankenship, Bolhar-Nordenkampf, Broun, Buer, Buer, Burbulis, Bush, Cecchetti, Christopher Wilkins, Church, Davis, Debeaujon, Debeaujon, Debeaujon, Diener, Durkee, Elinor P. Thompson, Gilmartin, Gitz, Gomez, Goodman, Green, Hideg, Higo, Hipkins, Hutzler, Ishida, Jacobs, Jaquinod, Jefferson, Jones, Julia M. Davies, Jung, Keijzer, Kerhoas, Kitamura, Koornneef, Lazar, Li, Macquet, Marinova, Mathews, Matsumoto, Mitsuda, Morant, Napoli, Nawrath, Nicolson, Omote, Peer, Peer, Peer, Pelletier, Pfündel, Pline, Porra, Preston, Rogers, Rohde, Routaboul, Sablowski, Sambrook, Sanders, Saslowsky, Scott, Shirley, Shirley, Taylor, Uhde-Stone, Vadim Demidchik, Walker, Xie, Zhao   +74 more
core   +2 more sources