Results 11 to 20 of about 962,118 (368)

Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. [PDF]

, 2016
ObjectivesThiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal ...
Fang, Liwei, Said, Hamid M, Sassoon, Catherine S, Subramanian, Veedamali S, Zhu, Ercheng   +4 more
core   +2 more sources

Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters

Frontiers in Pharmacology, 2020
High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for ...
Marija Ilic, Marija Ilic, Marija Ilic, Marion Holy, Kathrin Jaentsch, Matthias E. Liechti, Gert Lubec, Michael H. Baumann, Harald H. Sitte, Dino Luethi, Dino Luethi   +10 more
doaj   +1 more source

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Frontiers in Pharmacology, 2018
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated.
Zhenyan Hou, Zhenyan Hou, Lei Chen, Lei Chen, Pingfei Fang, Pingfei Fang, Hualin Cai, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Lingjuan Cao, Huande Li, Huande Li, Bikui Zhang, Bikui Zhang, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

An Arabidopsis flavonoid transporter is required for anther dehiscence and pollen development [PDF]

, 2010
FLOWER FLAVONOID TRANSPORTER (FFT) encodes a multidrug and toxin efflux family transporter in Arabidopsis thaliana. FFT (AtDTX35) is highly transcribed in floral tissues, the transcript being localized to epidermal guard cells, including those of the ...
Aarts, Beverley J. Glover, Blankenship, Bolhar-Nordenkampf, Broun, Buer, Buer, Burbulis, Bush, Cecchetti, Christopher Wilkins, Church, Davis, Debeaujon, Debeaujon, Debeaujon, Diener, Durkee, Elinor P. Thompson, Gilmartin, Gitz, Gomez, Goodman, Green, Hideg, Higo, Hipkins, Hutzler, Ishida, Jacobs, Jaquinod, Jefferson, Jones, Julia M. Davies, Jung, Keijzer, Kerhoas, Kitamura, Koornneef, Lazar, Li, Macquet, Marinova, Mathews, Matsumoto, Mitsuda, Morant, Napoli, Nawrath, Nicolson, Omote, Peer, Peer, Peer, Pelletier, Pfündel, Pline, Porra, Preston, Rogers, Rohde, Routaboul, Sablowski, Sambrook, Sanders, Saslowsky, Scott, Shirley, Shirley, Taylor, Uhde-Stone, Vadim Demidchik, Walker, Xie, Zhao   +74 more
core   +2 more sources

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Nature Communications, 2018
Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for ...
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker, Renae M Ryan   +4 more
doaj   +1 more source

Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats

Molecules, 2017
Our previous study showed that kurarinone was the main hepatotoxic ingredient of Sophora flavescens, accumulating in the liver. This study characterized the mechanism of Sophora flavescens extract (ESF) hepatotoxicity and hepatic accumulation of ...
Peng Jiang, Xiuwen Zhang, Yutong Huang, Nengneng Cheng, Yueming Ma   +4 more
doaj   +1 more source

Transport and transporters in the endoplasmic reticulum

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Enzyme activities localized in the luminal compartment of the endoplasmic reticulum are integrated into the cellular metabolism by transmembrane fluxes of their substrates, products and/or cofactors. Most compounds involved are bulky, polar or even charged; hence, they cannot be expected to diffuse through lipid bilayers.
Judit É. Magyar, Angelo Benedetti, Beáta Lizák, Silvia Senesi, Gábor Bánhegyi, Gábor Bánhegyi, Paola Marcolongo, Éva Margittai, Rosella Fulceri, Miklós Csala   +9 more
openaire   +6 more sources

Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]

, 2016
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June, Gasser, Paul J, Hurley, Matthew M., Pickel, Virginia M.   +3 more
core   +2 more sources

Evidence for Active Uptake and Deposition of Si-based Defenses in Tall Fescue

Frontiers in Plant Science, 2017
Silicon (Si) is taken up from the soil as monosilicic acid by plant roots, transported to leaves and deposited as phytoliths, amorphous silica (SiO2) bodies, which are a key component of anti-herbivore defense in grasses.
Emma McLarnon, Simon McQueen-Mason, Ingo Lenk, Susan E. Hartley   +3 more
doaj   +1 more source

Identifying the transporters of different flavonoids in plants [PDF]

, 2010
We recently identified a new component of flavonoid transport pathways in Arabidopsis. The MATE protein FFT (Flower Flavonoid Transporter) is primarily found in guard cells and seedling roots, and mutation of the transporter results in floral and growth ...
Beverley J. Glover, Elinor P. Thompson, Hruz T, Julia M. Davies   +3 more
core   +2 more sources