Results 11 to 20 of about 180,512 (273)

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Nature Communications, 2018
Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for ...
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker, Renae M Ryan   +4 more
doaj   +1 more source

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Frontiers in Pharmacology, 2018
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated.
Zhenyan Hou, Zhenyan Hou, Lei Chen, Lei Chen, Pingfei Fang, Pingfei Fang, Hualin Cai, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Lingjuan Cao, Huande Li, Huande Li, Bikui Zhang, Bikui Zhang, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

Generation of boron-deficiency-tolerant tomato by overexpressing an <i>Arabidopsis thaliana</i> borate transporter <i>AtBOR1</i>

Frontiers in Plant Science, 2014
Nutrient deficiency in soil poses a widespread agricultural problem. Boron (B) is an essential micronutrient in plants, and its deficiency causes defects in both vegetative and reproductive growth in various crops in the field.
Shimpei eUraguchi, Shimpei eUraguchi, Shimpei eUraguchi, Yuichi eKato, Yuichi eKato, Hideki eHanaoka, Kyoko eMiwa, Kyoko eMiwa, Toru eFUJIWARA, Toru eFUJIWARA   +9 more
doaj   +1 more source

Transporter-Driven Engineering of a Genetic Biosensor for the Detection and Production of Short-Branched Chain Fatty Acids in Saccharomyces cerevisiae

Frontiers in Bioengineering and Biotechnology, 2022
Biosensors can be used for real-time monitoring of metabolites and high-throughput screening of producer strains. Use of biosensors has facilitated strain engineering to efficiently produce value-added compounds.
Ryoma Miyake, Ryoma Miyake, Ryoma Miyake, Ryoma Miyake, Hua Ling, Hua Ling, Hua Ling, Jee Loon Foo, Jee Loon Foo, Jee Loon Foo, Nobutake Fugono, Matthew Wook Chang, Matthew Wook Chang, Matthew Wook Chang   +13 more
doaj   +1 more source

Transport and transporters in the endoplasmic reticulum

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Enzyme activities localized in the luminal compartment of the endoplasmic reticulum are integrated into the cellular metabolism by transmembrane fluxes of their substrates, products and/or cofactors. Most compounds involved are bulky, polar or even charged; hence, they cannot be expected to diffuse through lipid bilayers.
Judit É. Magyar, Angelo Benedetti, Beáta Lizák, Silvia Senesi, Gábor Bánhegyi, Gábor Bánhegyi, Paola Marcolongo, Éva Margittai, Rosella Fulceri, Miklós Csala   +9 more
openaire   +5 more sources

Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats

Molecules, 2017
Our previous study showed that kurarinone was the main hepatotoxic ingredient of Sophora flavescens, accumulating in the liver. This study characterized the mechanism of Sophora flavescens extract (ESF) hepatotoxicity and hepatic accumulation of ...
Peng Jiang, Xiuwen Zhang, Yutong Huang, Nengneng Cheng, Yueming Ma   +4 more
doaj   +1 more source

The front line transporter as the embodiment of the USSR military doctrine in the middle of the 20th century

Історія науки і техніки, 2022
The paper based on a source analysis of the history of creation, design, and production of LuAZ-967, LuAZ-967M, against the background of the processes of implementing projects of small tactical high mobility wheeled vehicles for the armies of European ...
Hryhorii Luparenko
doaj   +1 more source

Pathophysiological power of improper tonic GABAA conductances in mature and immature models

Frontiers in Neural Circuits, 2013
High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
doaj   +1 more source

Functional Characterization of the Saccharomyces cerevisiae Equilibrative Nucleoside Transporter 1 (ScENT1)

Molecules, 2018
Equilibrative nucleoside transporters (ENTs) are polytopic membrane transporters responsible for the translocation of nucleosides, nucleobases—to a lesser extent—and nucleoside analog therapeutics across cellular membranes.
Rebba C. Boswell-Casteel, Jennifer M. Johnson, Franklin A. Hays   +2 more
doaj   +1 more source

Map-compatible decomposition of transport paths [PDF]

arXiv, 2023
In the Monge-Kantorovich transport problem, the transport cost is expressed in terms of transport maps or transport plans, which play crucial roles there. A variant of the Monge-Kantorovich problem is the ramified (branching) transport problem that models branching transport systems via transport paths.
arxiv