Results 31 to 40 of about 180,512 (273)

ATP/ADP biosensor organoids for drug nephrotoxicity assessment

Frontiers in Cell and Developmental Biology, 2023
Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal ...
Koichiro Susa, Koichiro Susa, Koichiro Susa, Kenichi Kobayashi, Kenichi Kobayashi, Pierre Galichon, Pierre Galichon, Takuya Matsumoto, Takuya Matsumoto, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Navin R. Gupta, Navin R. Gupta, Navin R. Gupta, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane   +30 more
doaj   +1 more source

Synthesis of borate cross-linked rhamnogalacturonan II

Frontiers in Plant Science, 2015
In the present review, we describe current knowledge about synthesis of borate crosslinked rhamnogalacturonan II (RG-II) and it physiological roles. RG-II is a portion of pectic polysaccharide with high complexity, present in primary cell wall.
Hiroya eFunakawa, Kyoko eMiwa, Kyoko eMiwa   +2 more
doaj   +1 more source

Tracking multiple conformations occurring on angstrom-and-millisecond scales in single amino-acid-transporter molecules

eLife, 2023
Most membrane protein molecules undergo conformational changes as they transition from one functional state to another one. An understanding of the mechanism underlying these changes requires the ability to resolve individual conformational states, whose
Yufeng Zhou, John H Lewis, Zhe Lu
doaj   +1 more source

Prescription Advice Based on Data of Drug-Drug-Gene Interaction of Patients with Polypharmacy

Pharmacogenomics and Personalized Medicine, 2022
Sandro Salamone,1 Sara Spirito,2 Maurizio Simmaco,2 Marius Unger,1 Saskia Preissner,3 Björn-Oliver Gohlke,1 Andreas Eckert,1 Robert Preissner1 1Science-IT and Institute of Physiology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie ...
Salamone S, Spirito S, Simmaco M, Unger M, Preissner S, Gohlke BO, Eckert A, Preissner R   +7 more
doaj  

Tolerance to excess-boron conditions acquired by stabilization of a BOR1 variant with weak polarity in Arabidopsis

Frontiers in Cell and Developmental Biology, 2016
Boron (B) is a metalloid that is essential for plant growth but is toxic when present in excess. Arabidopsis BOR1 is a borate exporter, facilitating B translocation from root to shoot under limited-B conditions.
Shinji eWakuta, Teppei eFujikawa, Satoshi eNaito, Satoshi eNaito, Junpei eTakano   +4 more
doaj   +1 more source

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source

Transportes

Informes de la Construcción, 1960
El movimiento de materiales dentro de la Factoría está atendido por tres principales medios de transporte, en consonancia con las características del material y de los desplazamientos. Así se han establecido: sistemas de cintas transportadoras, una red ferroviaria de ancho normal y una completa malla de caminos enlazando funcionalmente las ...
openaire   +4 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Rice OsLHT1 Functions in Leaf-to-Panicle Nitrogen Allocation for Grain Yield and Quality

Frontiers in Plant Science, 2020
Proper allocation of nitrogen (N) from source leaves to grains is essential step for high crop grain yield and N use efficiency. In rice (Oryza sativa) grown in flooding paddy field, amino acids are the major N compounds for N distribution and re ...
Nan Guo, Mingji Gu, Jinqi Hu, Hongye Qu, Guohua Xu   +4 more
doaj   +1 more source