Modulation of Glycinergic Neurotransmission may Contribute to the Analgesic Effects of Propacetamol
Biomolecules, 2021 Treating neuropathic pain remains challenging, and therefore new pharmacological strategies are urgently required. Here, the enhancement of glycinergic neurotransmission by either facilitating glycine receptors (GlyR) or inhibiting glycine transporter ...
Lukas Barsch +3 more
doaj +1 more source
Identification of transporter genes from the fungal endophyte Neotyphodium lolii : this thesis is presented in partial fulfilment of the requirements for the degree of Master of Science (MSc) in Plant Biology at Massey University, Palmerston North, New Zealand / [PDF]
, 2006 Neotyphodium lolii is an endophytic fungus that lives in the pasture grass, Lolium perenne. They share a mutualistic symbiotic relationship. N. lolii lives out its life cycle within the plant and produces secondary metabolites, including alkaloids ...
Knox, Deborah Sian
core
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei [PDF]
, 2015 Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
De Koning, Harry P. +2 more
core +1 more source
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
Multiple Targeting Approaches on Histamine H3 Receptor Antagonists
Frontiers in Neuroscience, 2016 With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been
Mohammad eKhanfar +5 more
doaj +1 more source
Untargeted Metabolomics Uncovers the Essential Lysine Transporter in Toxoplasma gondii
Metabolites, 2021 Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, and cryptosporidiosis. Current treatments are limited by emerging resistance to, as well as the high cost and toxicity of existing drugs.
Joachim Kloehn +4 more
doaj +1 more source
Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]
, 2012 Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari +42 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Melatonin Improves Laying Performance by Enhancing Intestinal Amino Acids Transport in Hens
Frontiers in Endocrinology, 2018 The high concentration of melatonin (MEL) in the intestinal mucosa suggests that it has a special physiological function in intestine. In hens, previous studies have shown that MEL treatment promoted egg-laying performance.
Lijuan Liu +9 more
doaj +1 more source