Results 171 to 180 of about 16,112 (276)

Evolution Landscape of PiggyBac (PB) Transposon in Beetles (Coleoptera). [PDF]

open access: yesGenes (Basel)
Wang Q   +6 more
europepmc   +1 more source

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun   +7 more
wiley   +1 more source

Identification of Alzheimer's disease subtypes and biomarkers from human multi‐omics data using subspace merging algorithm

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song   +5 more
wiley   +1 more source

Enhanced Fc and complement activity of Fc‐modified avelumab boosts anti‐tumor activity but promotes NK cell fratricide

open access: yesClinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives The anti‐PD‐L1 antibody avelumab has demonstrated efficacy across multiple cancer types. Avelumab primarily blocks the PD‐1/L1 immune checkpoint, while inducing antibody‐dependent cellular cytotoxicity (ADCC) from CD16a+ NK cells.
Lachlan J Dobson   +6 more
wiley   +1 more source

In vivo CAR therapies: Turning the patient into their own CAR factory

open access: yesHemaSphere, Volume 10, Issue 5, May 2026.
Abstract Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo CAR approaches
François Vilcot   +3 more
wiley   +1 more source

The diversification of PHIS transposon superfamily in eukaryotes [PDF]

open access: yes, 2015
Chu-Lin Xiong   +5 more
core   +1 more source

Host Factor Induced Bacterial Extracellular Vesicles Promote Horizontal Gene Transfer in Vibrio cholerae

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Antimicrobial stressors, that is, bile or mitomycin C, induce enlarged, nucleic acid‐rich bacterial extracellular vesicles in Vibrio cholerae that facilitate horizontal gene transfer in vitro and during intestinal colonisation. The findings provide a detailed comparison of control versus stress‐induced vesicles, identify bile as a host factor shaping ...
Dominik Fleischhacker   +6 more
wiley   +1 more source

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