Advanced Science, Volume 13, Issue 41, 22 July 2026.High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao +10 more
wiley +1 more source
Emergence of bla<sub>NDM-1</sub> in Pseudomonas aeruginosa ST308 and ST773 from bloodstream infections in Egypt. [PDF]
BMC MicrobiolAbdulHak A +4 more
europepmc +1 more source
Genetic Code Expanded T Cell for Controllable Immunotherapy
Advanced Science, Volume 13, Issue 41, 22 July 2026.Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang +4 more
wiley +1 more source
Metagenomic analysis of heavy water-adapted bacterial communities. [PDF]
Microb GenomRivas-Santisteban J +9 more
europepmc +1 more source
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Plant MITEs: miniature transposable elements with major impacts. [PDF]
Mob DNASoundiramourtty A, Mirouze M.
europepmc +1 more source
Quantitative Control of Transposable Elements: From Genome Plasticity to Immune Regulatory Circuits
Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.ABSTRACT Transposable elements (TEs) constitute nearly half of the human genome and are increasingly recognized as context‐dependent regulators of genome function rather than passive repetitive DNA. This Review synthesizes classical and recent evidence on TE biology, including TE classification, mechanisms of mobilization, host restriction pathways ...
Irving Jesús Reyes‐Barragán
wiley +1 more source
Antibiotic Resistance Genes in the Subgingival Microbiome in Periodontitis: A Scoping Review of Prevalence, Mobility, and Future Directions. [PDF]
CureusOzturk SZ, Aydin B, Cifcibasi E.
europepmc +1 more source
A versatile CRISPR-associated transposases-mediated toolkit for transcriptional regulation library. [PDF]
Nucleic Acids ResZhang Y +9 more
europepmc +1 more source
Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives
MedComm, Volume 7, Issue 7, July 2026.Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang +9 more
wiley +1 more source