Results 181 to 190 of about 16,112 (276)

Prevalence and Evolutionary Implications of Genome Rearrangements in Bacteria. [PDF]

Genome Biol Evol
Martinez-Gutierrez CA, Huang Y, Bobay LM.   +2 more
europepmc   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, Volume 31, Issue 5, Page 484-497, May 2026.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Antimicrobial Resistant Factors in <i>Klebsiella pneumoniae</i> Strains Isolated From Urinary Tract Infections, Wound Infections, Hospital Wastewater, and Cervical Cancers From Ghana, Togo, and Benin. [PDF]

Int J Genomics
Yakubu B.
europepmc   +1 more source

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging

Aging Cell, Volume 25, Issue 5, May 2026.
T cells are the most dynamically altered immune population in the aged liver. Accumulation of CD8+ Tex in aged livers. Spatial enrichment of CD8+ Tex in the portal vein zone. PP hepatocytes promote T cell exhaustion via Lpin1. T cell exhaustion correlates with liver disease progression.
Jiahua Lu, Yuqian Wang, Wenxue Zhao, Zihao Zhao, Zhaoya Gao, Jin Gu, Cheng Li, Jie Cheng   +7 more
wiley   +1 more source

Heterogeneous Lineages of DNA Transposons Encode a TET/JBP Dioxygenase in Fungi. [PDF]

Biology (Basel)
Kojima KK.
europepmc   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

Engineering of BZ transposase and transposon donor vector for enhanced efficiency and safety in gene delivery applications. [PDF]

Nucleic Acids Res
Wang S, Zhang P, Sun Y, Fang Y, Wang P, Shao M, Zhang N, Shi S, Chen X, Gao H, Cheng J, Gao B, Liu T, Qian Q, Song C.   +14 more
europepmc   +1 more source

Cell‐type‐specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves

New Phytologist, Volume 250, Issue 4, Page 2007-2025, May 2026.
Summary In plants, multiple cell types contribute to immunity, but what division of labor exists among cell types when immunity is activated? We compared, at single‐cell resolution, the response of Arabidopsis thaliana leaf cells during pattern‐triggered and effector‐triggered immunity (PTI/ETI), sampled at 3 and 5 h after infection with Pseudomonas ...
Shanshan Wang, Ilja Bezrukov, Pin‐Jou Wu, Hannah Gauß, Marja Timmermans, Detlef Weigel   +5 more
wiley   +1 more source

Dynamics of a large multidrug-resistant plasmid encoding New Delhi metallo-β-lactamase-1 and oxacillinase-58 carbapenemases in <i>Acinetobacter baumannii</i> clinical isolates from a tertiary hospital in Malaysia. [PDF]

Microb Genom
Din NS, Mohd Rani F, Ismail S, Rahman NIA, Cheah HL, Tan HS, Rahman S, Cleary DW, Ayub Q, Clarke SC, Yeo CC.   +10 more
europepmc   +1 more source

Rare Natural SNP Activates SHOOT APICAL MERISTEM ENLARGER1 to Increase Branch Number and Silique Number on the Main Inflorescence in Brassica napus

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2768-2786, May 2026.
ABSTRACT Brassica napus is the second most important oil crop worldwide. Number of primary branches (Branch number, BN) and silique number on the main inflorescence (SMI) are key yield‐related quantitative traits. Here, we cloned a major QTL, qDB.A09, which simultaneously influences BN and SMI.
Sihao Zhang, Bao Li, Xiaoting Li, Song Yu, Yebitao Yang, Peipei Liu, Tanglingdian He, Wei Wang, Mei Li, Liang Guo, Jinxing Tu   +10 more
wiley   +1 more source