Results 271 to 280 of about 11,351 (298)
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Stoichiometric use of the transposase of bacteriophage Mu
Cell, 1984The transposase of bacteriophage Mu (gene A protein) mediates the coupled replication and integration processes that constitute transposition during the lytic cycle. Our previous results showed that the activity of the A protein is unstable, as its continued synthesis is required to maintain Mu DNA replication throughout the lytic cycle.
M L, Pato, C, Reich
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Integrating DNA: Transposases and Retroviral Integrases
Annual Review of Microbiology, 1999▪ Abstract Transposable elements appear quite disparate in their organization and in the types of genetic rearrangements they promote. In spite of this diversity, retroviruses and many transposons of both prokaryotes and eukaryotes show clear similarities in the chemical reactions involved in their transposition.
L, Haren, B, Ton-Hoang, M, Chandler
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Molecular architecture of a eukaryotic DNA transposase
Nature Structural & Molecular Biology, 2005Mobile elements and their inactive remnants account for large proportions of most eukaryotic genomes, where they have had central roles in genome evolution. Over 50 years ago, McClintock reported a form of stress-induced genome instability in maize in which discrete DNA segments move between chromosomal locations.
Alison B, Hickman +7 more
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Repression of the Ac‐transposase gene promoter by Ac transposase
The Plant Journal, 1996SummaryMobility of the maize Ac‐Ds transposable element family depends on the production of Ac‐encoded transposase (TPASE). The TPASE is a DNA‐binding protein which recognizes internal sites near both Ac termini in a region which overlaps the putative TPASE gene promoter. Therefore, it was hypothesized that TPASE may regulate its own transcription. The
Marcelo Fridlender +3 more
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First Mariner Mos1 transposase inhibitors.
Mini reviews in medicinal chemistry, 2009We described chemical inhibitors of Mos1 transposition. Some were already known to affect a related prokaryotic transposase (Tn5) or HIV-1 integrase, whereas the other were new compounds in this field. The new compounds were all organized around a bis-(heteroaryl)maleimides scaffold.
Bouchet, Nicolas +9 more
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Factors that affect transposition mediated by the Tn21 transposase
Plasmid, 1988The frequencies of one-ended transposition mediated by the Tn21 transposase acting on plasmids containing 38-bp inverted repeat sequences (IRs) of both Tn21 and of Tn501/Tn1721 and Tn2501 were measured. The enzyme acted on all these IRs, but more efficiently on the homologous sequences. These differences were magnified when the enzyme acted on plasmids
J, Grinsted, C, Martin, F, de la Cruz
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2008
One of the greatest paradigm shifts in the early days of molecular biology was the discovery of DNA transposition by Barbara McClintock in 1948.1 Working with maize, McClintock realized that certain chromosomal elements had the ability to move from one location to another in the genome,2 an observat...
Fred Dyda, Alison Burgess Hickman
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One of the greatest paradigm shifts in the early days of molecular biology was the discovery of DNA transposition by Barbara McClintock in 1948.1 Working with maize, McClintock realized that certain chromosomal elements had the ability to move from one location to another in the genome,2 an observat...
Fred Dyda, Alison Burgess Hickman
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Mechanism of target site selection by type V-K CRISPR-associated transposases
Science, 2023Jerrin Thomas George +2 more
exaly
[Modification and decoration of transposase: a review].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2015Transposons are the mobile and autonomic replication DNA fragments in genomes. With more understanding of the structure and function of transposons, numerous transposons have been developed to the genetics tool for gene function analysis, gene transformation and gene therapy.
Qianqian, Zhou, Mingbing, Zhou
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