mBio, 2017 For decades, identifying the regions of a bacterial chromosome that are necessary for viability has relied on mapping integration sites in libraries of random transposon mutants to find loci that are unable to sustain insertion.
M. DeJesus +11 more
semanticscholar +1 more source
Genome-Wide Transposon Screen of a Pseudomonas syringae mexB Mutant Reveals the Substrates of Efflux Transporters. [PDF]
, 2019 Bacteria express numerous efflux transporters that confer resistance to diverse toxicants present in their environment. Due to a high level of functional redundancy of these transporters, it is difficult to identify those that are of most importance in ...
Deutschbauer, Adam M +4 more
core +1 more source
Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates. [PDF]
, 2013 The efficient production of biofuels from cellulosic feedstocks will require the efficient fermentation of the sugars in hydrolyzed plant material.
Arkin, Adam P +14 more
core +2 more sources
Transposon-Based CAR T Cells in Acute Leukemias: Where Are We Going?
Cells, 2020 Chimeric Antigen Receptor (CAR) T-cell therapy has become a new therapeutic reality for refractory and relapsed leukemia patients and is also emerging as a potential therapeutic option in solid tumors. Viral vector-based CAR T-cells initially drove these
Chiara F. Magnani +6 more
doaj +1 more source
Gene transfer in the GI tract and oral cavity [PDF]
, 2000 Gene transfer is important in spreading antibiotic resistance and other traits such as virulence factors. In this review the molecular mechanisms of gene transfer are outlined and the biological consequences of bacterial gene transfer in the GI tract and
Mullany, P
core +1 more source
Structure and evolution of chlorate reduction composite transposons. [PDF]
, 2013 UnlabelledThe genes for chlorate reduction in six bacterial strains were analyzed in order to gain insight into the metabolism. A newly isolated chlorate-reducing bacterium (Shewanella algae ACDC) and three previously isolated strains (Ideonella ...
Clark, Iain C +3 more
core +2 more sources
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]
, 2015 BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L +6 more
core +6 more sources
The CACTA transposon Bot1 played a major role in Brassica genome divergence and gene proliferation [PDF]
, 2008 We isolated and characterized a Brassica C genome-specific CACTA element, which was designated Bot1 (Brassica oleracea transposon 1). After analysing phylogenetic relationships, copy numbers and sequence similarity of Bot1 and Bot1 analogues in B ...
AGI, Arabidopsis Genome Initiative +80 more
core +1 more source
SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]
, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F +8 more
core +1 more source
Host–transposon interactions: conflict, cooperation, and cooption
Genes & Development, 2019 In this review, Cosby et al. argue that the evolutionary success of TEs cannot be explained solely by evasion from host control mechanisms; rather, some TEs have evolved commensal and even mutualistic strategies that mitigate the cost associated with ...
Rachel L. Cosby +2 more
semanticscholar +1 more source