Results 31 to 40 of about 111,214 (295)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Transposon-insertion sequencing (TIS) in S. Typhimurium ST313 D23580.

, 2019
Schematic representation of the S. Typhimurium D23580 transposon library and growth conditions used in this study. The Venn diagram corresponds to S4B Fig.
Michael Ibba (250023), Rocío Canals (595216), Roy R. Chaudhuri (7439600), Jay C. D. Hinton (7439615), Natalia Quinones-Olvera (7439609), Siân V. Owen (7439606), Michael Baym (606968), Melita A. Gordon (7439612), Rebecca E. Steiner (7439603)   +8 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Passport, a native Tc1 transposon from flatfish, is functionally active in vertebrate cells [PDF]

, 2009
The Tc1/mariner family of DNA transposons is widespread across fungal, plant and animal kingdoms, and thought to contribute to the evolution of their host genomes.
Foster, Linda K, Fahrenkrug, Scott C, Clark, Karl J, Leaver, Michael, Carlson, Daniel F   +4 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Novel Transposon Tn7709 Harbors Multidrug Resistance Genes in a Pathogenic Aeromonas media Strain QST31

Microorganisms
Pathogenic Aeromonas spp. are the etiological agents of Motile Aeromonas Septicemia (MAS). This study aimed to identify the pathogen of diseased tadpoles (Quasipaa spinosa) and the antibiotic-resistance characteristics of this bacterium.
Baodi Shang, Xiaoyi Li, Xiaoping Zhang, Meiyan Zhang, Jie Kong, Jinle Wang, Aiping Tan, Feng Zhao, Defeng Zhang   +8 more
doaj   +1 more source

Pink Bollworm Resistance to Bt Toxin Cry1Ac Associated with an Insertion in Cadherin Exon 20

Toxins, 2019
Insecticidal proteins from Bacillus thuringiensis (Bt) are widely used to control insect pests, but their efficacy is reduced when pests evolve resistance.
Ling Wang, Yuemin Ma, Xueqin Guo, Peng Wan, Kaiyu Liu, Shengbo Cong, Jintao Wang, Dong Xu, Yutao Xiao, Xianchun Li, Bruce E. Tabashnik, Kongming Wu   +11 more
doaj   +1 more source

형질전환복제돼지 생산을 위한 piggyBac transposon system의 적용 [PDF]

, 2017
학위논문 (박사)-- 서울대학교 대학원 : 수의학과, 2017. 2. 이병천.PiggyBac transposon has been widely employed to generation transgenic animals using a "cut and paste" mechanism that is occurred by piggyBac transposase recognizing transposon-specific inverted terminal repeat ...
김수진
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Discovery of a New Starship Transposon Driving the Horizontal Transfer of the ToxA Virulence Gene in Alternaria ventricosa

Microorganisms
The virulence gene ToxA has been proposed to be horizontally transferred between three fungal wheat pathogens (Parastagonospora nodorum, Pyrenophora tritici-repentis, and Bipolaris sorokiniana) as part of a conserved ~14 kb ToxhAT transposon.
Fei Liu, Ratchadawan Cheewangkoon, Rui-Lin Zhao   +2 more
doaj   +1 more source