Results 91 to 100 of about 49,131 (302)

Transposon-directed insertion-site sequencing (TraDIS) analysis of Enterococcus faecium using nanopore sequencing and a WebAssembly analysis platform

Microbiology Spectrum
Vancomycin-resistant Enterococcus faecium (VREfm) are healthcare-associated opportunistic pathogens of global significance. Genetic tools are needed to understand the molecular basis for VREfm clinically relevant phenotypes, such as persistence within ...
Alexandra L. Krause, Wytamma Wirth, Adrianna M. Turner, Louise Judd, Lucy Li, Willem van Schaik, Benjamin P. Howden, Glen P. Carter, Torsten Seemann, Ryan Wick, Timothy P. Stinear, Andrew H. Buultjens, Ian R. Monk   +12 more
doaj   +1 more source

Heterochromatic histone modifications at transposons in Xenopus tropicalis embryos

, 2016
Contains fulltext : 165656.pdf (Publisher’s version ) (Open Access)Transposable elements are parasitic genomic elements that can be deleterious for host gene function and genome integrity.
Elurbe, D.M., Hontelez, S., Kruijsbergen, I. van, Huynen, M.A., Heeringen, S.J. van, Veenstra, G.J., Veenstra, G.J.C.   +6 more
core   +1 more source

Small RNAs and regulation of transposons in plants [PDF]

, 2013
RNA interference is now a well-recognized post-transcriptional mechanism for regulation of gene expression in both animals and plants. In this process, microRNAs (miRNAs) direct silencing complexes to complementary RNA sequences, leading to either ...
Ito, Hidetaka
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

eLife
Repression of retrotransposition is crucial for the successful fitness of a mammalian organism. The domesticated transposon protein L1TD1, derived from LINE-1 (L1) ORF1p, is an RNA-binding protein that is expressed only in some cancers and early ...
Gülnihal Kavaklioglu, Alexandra Podhornik, Terezia Vcelkova, Jelena Marjanovic, Mirjam A Beck, Trinh Phan-Canh, Theresia Mair, Claudia Miccolo, Aleksej Drino, Mirko Doni, Gerda Egger, Susanna Chiocca, Miha Modic, Christian Seiser   +13 more
doaj   +1 more source

Algorithms for determining transposons in gene sequences

, 2022
Some genes can change their relative locations in a genome. Thus for different individuals of the same species, the orders of genes might be different. Such jumping genes are called transposons.
Wang, Yue
core  

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Diversity of Harbinger-like Transposons in Teleost Fish Genomes

, 2022
International audienceSimple Summary The study of transposable elements, which are repeated DNA sequences that can insert into new locations in genomes, is of particular interest to genome evolution, as they are sources of mutations but also of new ...
Etchegaray, Ema, Jérémy Barbier, Magali Naville, Ema Etchegaray, Jean-Nicolas Volff, Volff, Jean-Nicolas, Corentin Dechaud, Naville, Magali, Barbier, Jérémy, Dechaud, Corentin   +9 more
core   +1 more source

Asking the 5 W's for designing next‐generation bioprocessing

AIChE Journal, EarlyView.
Abstract Biotechnology is expanding beyond traditional, centralized fermentation and toward next‐generation bioprocessing paradigms that emphasize flexible deployment outside the laboratory with application‐specific performance. However, many bioprocesses fail to translate beyond proof‐of‐concept into industrially viable systems because early design ...
Sangdo Yook, Karoline Maria Vieira Nogueira, Raj Sukumar, Jenna Miller, Hal S. Alper   +4 more
wiley   +1 more source

Insertion of miniature subterminal inverted repeat-like elements in diapause-regulated genes in the Colorado potato beetle, Leptinotarsa decemlineata (Coleoptera: Chrysomelidae)

European Journal of Entomology, 2011
Determining the genomic structure of diapause-associated transcripts (DAT) -2 and -3 led to the isolation of four novel miniature subterminal inverted repeat-like elements (MSITE): Mild-1, -2, -3 and -4.
George D. YOCUM, Michelle J. TOUTGES, Richard L. ROEHRDANZ, Preston J. DIHLE   +3 more
doaj   +1 more source