Results 51 to 60 of about 52,950 (251)

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

RNA silencing proteins and small RNAs in oomycete plant pathogens and biocontrol agents

Frontiers in Microbiology, 2023
IntroductionOomycetes cause several damaging diseases of plants and animals, and some species also act as biocontrol agents on insects, fungi, and other oomycetes.
Edoardo Piombo, Bekele Gelena Kelbessa, Poorva Sundararajan, Stephen C. Whisson, Ramesh Raju Vetukuri, Mukesh Dubey   +5 more
doaj   +1 more source

Excision of Sleeping Beauty transposons: parameters and applications to gene therapy [PDF]

, 2004
A major problem in gene therapy is the determination of the rates at which gene transfer has occurred. Our work has focused on applications of the Sleeping Beauty (SB) transposon system as a non-viral vector for gene therapy.
Hackett, PB, Discovery Genom Inc, 614 McKinley Pl NE, Minneapolis, MN 55413 USA, Perry B. Hackett, Elena L. Aronovich, Chester B. Whitley, Geyi Liu, Zongbin Cui   +5 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Heterochromatic histone modifications at transposons in Xenopus tropicalis embryos [PDF]

, 2016
Contains fulltext : 165656.pdf (Publisher’s version ) (Open Access)Transposable elements are parasitic genomic elements that can be deleterious for host gene function and genome integrity.
Elurbe, D.M., Hontelez, S., Kruijsbergen, I. van, Huynen, M.A., Heeringen, S.J. van, Veenstra, G.J., Veenstra, G.J.C.   +6 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Characterization of a NDM-1- Encoding Plasmid pHFK418-NDM From a Clinical Proteus mirabilis Isolate Harboring Two Novel Transposons, Tn6624 and Tn6625

Frontiers in Microbiology, 2019
Acquisition of the blaNDM–1 gene by Proteus mirabilis is a concern because it already has intrinsic resistance to polymyxin E and tigecycline antibiotics. Here, we describe a P.
Dandan Dong, Dandan Dong, Dandan Dong, Manli Li, Manli Li, Zhenzhen Liu, Zhenzhen Liu, Jiantao Feng, Jiantao Feng, Nan Jia, Hui Zhao, Baohua Zhao, Tingting Zhou, Xianglilan Zhang, Yigang Tong, Yigang Tong, Yuanqi Zhu, Yuanqi Zhu   +17 more
doaj   +1 more source

Mobilization of giant piggyBac transposons in the mouse genome [PDF]

, 2011
The development of technologies that allow the stable delivery of large genomic DNA fragments in mammalian systems is important for genetic studies as well as for applications in gene therapy.
Zemin Ning, Meng Amy Li, Allan Bradley, Tomas W. Fitzgerald, Daniel J. Turner, Nancy L. Craig, Kosuke Yusa, Lena Rad, Qi Liang, Sabine Eckert   +9 more
core   +2 more sources