Results 51 to 60 of about 49,131 (302)
Research progress in gene editing technology
Frontiers in Bioscience-Landmark, 2021 As a tool for modifying the genome, gene editing technology has developed rapidly in recent years, especially in the past two years. With the emergence of new gene editing technologies, such as transposon editing tools, numerous advancements have been
Sheng Huang +9 more
doaj +1 more source
Genomic distribution of H3K9me2 and DNA methylation in a maize genome.
PLoS ONE, 2014 DNA methylation and dimethylation of lysine 9 of histone H3 (H3K9me2) are two chromatin modifications that can be associated with gene expression or recombination rate.
Patrick T West +7 more
doaj +1 more source
DDM1-Mediated TE Silencing in Plants
Plants, 2023 Epigenetic modifications are indispensable for regulating gene bodies and TE silencing. DECREASE IN DNA METHYLATION 1 (DDM1) is a chromatin remodeller involved in histone modifications and DNA methylation.
Ruth Y. Akinmusola +2 more
doaj +1 more source
Transposons and CRISPR: Rewiring Gene Editing
, 2022 CRISPR-Cas is driving a gene editing revolution because of its simple reprogramming. However, off-target effects and dependence on the double-strand break repair pathways impose important limitations.
Montoya, Guillermo +5 more
core +1 more source
Учёные записки Казанского университета: Серия Естественные науки, 2019 Phytopathogenic strains of Fusarium oxysporum can parasitize on more than 120 species of crops and ornamental plants posing a serious danger to world agriculture. The wide range of hosts can be evidence of fast changes in the genomes of F.
D.M. Afordoanyi +2 more
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Advanced Science, EarlyView.A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun +23 more
wiley +1 more source
Excision of Sleeping Beauty transposons: parameters and applications to gene therapy [PDF]
, 2004 A major problem in gene therapy is the determination of the rates at which gene transfer has occurred. Our work has focused on applications of the Sleeping Beauty (SB) transposon system as a non-viral vector for gene therapy.
Hackett, PB, Discovery Genom Inc, 614 McKinley Pl NE, Minneapolis, MN 55413 USA +5 more
core
Cooptions and convergence of diverse Tn7-like transposons
, 2022 277 pagesDiverse mobile genetic elements shape bacterial genome evolution and provide countless genomics tools. Tn7-like transposons are notable for their tight control of targeted transposition.
Hsieh, Shan-Chi
core +1 more source