Results 91 to 100 of about 60,909 (346)

Diagnosis of Transthyretin Amyloid Cardiomyopathy [PDF]

Cardiology and Therapy, 2020
Transthyretin amyloid cardiomyopathy (ATTR-CM) continues to be an easily overlooked, life-threatening, yet treatable cause of heart failure. Furthermore, its elusive diagnosis leads to late or misdiagnosis. As therapeutic advancements such as tafamidis usher in a promising new era in the management of ATTR-CM, the need for disease awareness and ...
Adam Hafeez, Anthony A. Bavry
openaire   +3 more sources

Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants

Nature Communications
Transthyretin is a transport protein whose misfolding has been implicated in the development of cardiac amyloidosis. Here, we examine the clinical correlates of transthyretin levels, the differences in transthyretin levels according to the pathogenic ...
Naman S. Shetty, Mokshad Gaonkar, Nirav Patel, Akhil Pampana, Nehal Vekariya, Peng Li, Garima Arora, Pankaj Arora   +7 more
doaj   +1 more source

Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells [PDF]

, 2019
Early detection of lung cancer offers an important opportunity to decrease mortality while it is still treatable and curable. Thirteen secretory proteins that are Stat3 downstream gene products were identified as a panel of biomarkers for lung cancer ...
Ding, Xinchun, Du, Hong, Lee, Chih-Chun, Perkins, Susan, Wu, Lingyan, Yan, Cong, Zhao, Ting   +6 more
core   +1 more source

Clinical features and predictors of atrial fibrillation in patients with light‐chain or transthyretin cardiac amyloidosis

ESC Heart Failure, 2022
The study aimed to investigate the prevalence, phenotypic characteristics, and predictors of atrial fibrillation (AF) in patients presenting with cardiac amyloidosis (CA) of light‐chain (AL) or transthyretin (ATTR) type.
M. Papathanasiou, A. Jakstaite, Sara Oubari, J. Siebermair, R. Wakili, J. Hoffmann, A. Carpinteiro, T. Hagenacker, A. Thimm, C. Rischpler, L. Kessler, T. Rassaf, P. Luedike   +12 more
semanticscholar   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Oligonucleotide Drugs for Transthyretin Amyloidosis [PDF]

New England Journal of Medicine, 2018
In this issue of the Journal, Adams et al.1 and Benson et al.2 report the results of two randomized, double-blind, controlled trials testing the therapeutic efficacy of two different chemically mod...
Adams, D, Hawkins, PN, Polydefkis, M
openaire   +7 more sources

Frequency of hereditary transthyretin amyloidosis among elderly patients with transthyretin cardiomyopathy

European Journal of Heart Failure, 2022
AbstractAimsTransthyretin amyloid cardiomyopathy (ATTR‐CM) is increasingly recognized as a cause of heart failure in the elderly. Although wild‐type transthyretin amyloidosis is the most frequent form of ATTR‐CM found in the elderly, hereditary transthyretin amyloidosis (ATTRv) can also occur.
Maestro Benedicto, Alba, Vela, Paula, Frutos, Fernando de, Mora, Nerea, Pomares, Antonia, Gonzalez Vioque, Emiliano, Briceño, Ana, Cabrera, Eva, Cobo Marcos, Marta, Dominguez, Fernando, Gonzalez-Lopez, Esther, Segovia Cubero, Javier, Lara Pezzi, Enrique, García Pavía, Pablo   +13 more
openaire   +6 more sources

Subthreshold Aortic Valve Calcium Scores in Severe Aortic Stenosis and Transthyretin Cardiac Amyloidosis

JACC: Case Reports, 2020
We have clinically observed that some patients with transthyretin cardiac amyloidosis and severe aortic stenosis may have lesser degrees of calcification than one might expect.
Muzna Hussain, MD, Mazen Hanna, MD, Leonardo Rodriguez, MD, Brian Griffin, MD, Chris Watson, MD PhD, Dermot Phelan, MD, Paul Schoenhagen, MD, Wael Jaber, MD, Paul Cremer, MD, Patrick Collier, MD, PhD   +9 more
doaj   +1 more source

Semi-Quantitative Models for Identifying Potent and Selective Transthyretin Amyloidogenesis Inhibitors [PDF]

, 2017
Rate-limiting dissociation of the tetrameric protein transthyretin (TTR), followed by monomer misfolding and misassembly, appears to cause degenerative diseases in humans known as the transthyretin amyloidoses, based on human genetic, biochemical and ...
Choi, Sungwook, Connelly, Stephen, Johnson, Steven M., Kelly, Jeffery W., Mortenson, David E., Powers, Evan T., Wilson, Ian A.   +6 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source