Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease [PDF]
, 2012 Transthyretin (TTR) protects against A-Beta toxicity by binding the peptide thus inhibiting its aggregation. Previous work showed different TTR mutations interact differently with A-Beta, with increasing affinities correlating with decreasing ...
Cardoso, Isabel +2 more
core +2 more sources
The Journey of Human Transthyretin: Synthesis, Structure Stability, and Catabolism
Biomedicines, 2022 Transthyretin (TTR) is a homotetrameric protein mainly synthesised by the liver and the choroid plexus whose function is to carry the thyroid hormone thyroxine and the retinol-binding protein bound to retinol in plasma and cerebrospinal fluid.
C. Sanguinetti +9 more
semanticscholar +1 more source
The Immune Microenvironment in Liver Cancer: From Analysis to Targeting
Advanced Science, EarlyView.This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan +5 more
wiley +1 more source
Differences in transcription between free-living and CO_2-activated third-stage larvae of Haemonchus contortus [PDF]
, 2010 Background: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide. The infective third-stage larva (L3) of this gastric nematode is enclosed in a cuticle (sheath) and, once
Aleman-Meza, Boanerges +11 more
core +6 more sources
Annals of Neurology, EarlyView.Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell +3 more
wiley +1 more source
Case Report: Transthyretin Glu54Leu—a rare mutation with predominant cardiac phenotype
Frontiers in Cardiovascular Medicine, 2023 We report two unrelated Bulgarian families with hereditary transthyretin (ATTR) amyloidosis due to a rare p.Glu74Leu (Glu54Leu) pathogenic variant found in seven individuals—three of them symptomatic.
Mariana Gospodinova +15 more
doaj +1 more source
Amyloid Deposits in a Bone Marrow Biopsy Alongside a Presumed Causative Clone. [PDF]
EJHaemeJHaem, Volume 6, Issue 6, December 2025.
Banerjee R, Das MK, Smith KD.
europepmc +2 more sources
Bioelectrical Impedance Analysis (BIA)-derived Phase Angle (PA) is a practical aid to nutritional assessment in hospital in-patients [PDF]
, 2019 Background: Nutritional status can be difficult to assess. Bioelectrical impedance analysis (BIA)-derived phase angle (PA), and the plasma markers citrulline and transthyretin (pre-albumin) have the potential to assist, but the protocol of fasting and ...
Alexandre, L +8 more
core +1 more source
Molecular mechanisms and emerging therapies in wild-type transthyretin amyloid cardiomyopathy
Heart Failure ReviewsWild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause of heart failure due to misfolded wild-type transthyretin (TTRwt) myocardial deposition.
Danni Wu, Wei Chen
semanticscholar +1 more source
ESC Heart Failure, 2022 Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) improve clinical outcomes in heart failure patients with reduced and preserved left ventricular ejection fraction (LVEF), but have not yet been investigated in transthyretin amyloid cardiomyopathy (ATTR ...
S. Dobner +7 more
semanticscholar +1 more source