Results 101 to 110 of about 45,139 (271)

Genotype-Phenotype Correlation of a Rare Transthyretin Variant Causing AmyloidosisNovel Teaching Points

CJC Open, 2022
Left ventricular hypertrophy is a common entity with a broad differential diagnosis. We present a case of a middle-aged woman with left ventricular hypertrophy and neuropathy caused by a rare transthyretin variant in the absence of a family history or ...
Ammar G. Chaudhary, MBChB, FRCPC, Fadi M. AlReefi, MD, Riad G. Abou Zahr, MD, FSCMR, Hossam A. Elzeftawy, MD, Saleh S. Alghamdi, MD, Areej A. Bushnag, MD, Jaudah A. Al-Maghrabi, MD, MSc, FRCPC, Iman S. Abumansour, MD   +7 more
doaj  

Microvascular obstruction in cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Abstract Aims Cardiac amyloidosis (CA) is characterized by deposition of amyloid fibrils within the extracellular space, causing disarray of the myocardial structure and capillary architecture. This study aims to characterize the prevalence of microvascular obstruction (MVO) in patients with CA and to assess the association between MVO and prognosis ...
Lucrezia Netti, Adam Ioannou, Ana Martinez‐Naharro, Yousuf Razvi, Aldostefano Porcari, Lucia Venneri, Viviana Maestrini, Dan Knight, Ruta Virsinskaite, Muhammad U. Rauf, Tushar Kotecha, Rishi K. Patel, Ashutosh Wechelakar, Helen Lachmann, Peter Kellman, Charlotte Manisty, James Moon, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana   +19 more
wiley   +1 more source

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein [PDF]

, 2016
Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals.
Biasini, Emiliano, Borsello, Tiziana, Castilla, Joaqu\uedn, Cerovic, Milica, Cimini, Sara, Elezgarai, Saioa R., Gobbi, Marco, Massignan, Tania, Moreno, Jorge, Negro, Alessandro, Nonno, Romolo, Restelli, Elena, Riccardi, Geraldina, Sangiovanni, Valeria, Stincardini, Claudia, Stravalaci, Matteo, Vanni, Ilaria   +16 more
core   +1 more source

Synthesis and structural analysis of the N-terminal domain of the thyroid hormone-binding protein transthyretin [PDF]

, 2002
Transthyretin (TTR) is a 55 kDa protein responsible for the transport of thyroid hormones and retinol in human serum. Misfolded forms of the protein are implicated in the amyloid diseases familial amyloidotic polyneuropathy and senile systemic ...
Hamilton JA, Hamilton JA, Jacobson DR, Jarvis JA, Nilsson SF, Saraiva MJ, Schnolzer M, Terry CJ, Thylen C, Wojtczak A   +9 more
core   +1 more source

Skeletal muscle and subcutaneous fat quantity as prognostic indicators in cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Aims Disease‐related changes in body composition are associated with worse outcomes in chronic heart failure. In cardiac amyloidosis (CA), the prognostic value of direct body composition measures is understudied. Methods and results We identified 160 consecutive patients with CA (transthyretin [ATTR] or light chain [AL]) diagnosed between 2001 and 2021
Joshua Longinow, Saeid Mirzai, Po‐Hao Chen, Mazen Hanna, W.H. Wilson Tang   +4 more
wiley   +1 more source

Label-free quantitative comparison of cerebrospinal fluid glycoproteins and endogenous peptides in subjects with Alzheimer's disease, mild cognitive impairment, and healthy individuals [PDF]

, 2016
PURPOSE: The goal of this study is to investigate putative molecular dynamic changes in cerebrospinal fluids (CSFs) collected from individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) as compared to healthy controls ...
Asthana, S, Carlsson, C, Cunningham, R, Li, L, Okonkwo, O, Wang, J, Zetterberg, H   +6 more
core   +1 more source

Cryptogenic ischemic stroke in cardiac transthyretin amyloidosis and sinus rhythm: a case report

Frontiers in Cardiovascular Medicine
Cardiac amyloidosis is a group of diseases characterized by the deposition of amyloid fibers in cardiac tissue. Two forms are mainly reported: light chain (AL) and transthyretin (ATTR) amyloidosis.
Angela Napolitano, Serena Toffanin, Cristiana Bulato, Elena Campello, Paolo Simioni, Luca Spiezia   +5 more
doaj   +1 more source

Transthyretin increases migration and invasion of rat placental trophoblast cells

FEBS Open Bio, 2020
Preeclampsia (PE) is a hypertensive disorder of pregnancy. Early diagnosis of PE is currently contingent on regular prenatal physical examinations and may be facilitated by identification of novel diagnostic markers.
Xiao‐Peng Ma, Chong‐Dong Liu, Guang‐Ming Cao, Zhen‐Yu Zhang   +3 more
doaj   +1 more source

Long‐term efficacy of tafamidis in patients with transthyretin amyloid cardiomyopathy by National Amyloidosis Centre stage

European Journal of Heart Failure, EarlyView.
Long‐term efficacy of tafamidis in patients with ATTR‐CM in ATTR‐ACT and its LTE by NAC stage at ATTR‐ACT baseline. ATTR‐ACT, Tafamidis in Transthyretin Cardiomyopathy Clinical Trial; ATTR‐CM, transthyretin amyloid cardiomyopathy; NAC, National Amyloidosis Centre.
Thibaud Damy, Rong Wang, Mathew S. Maurer, Julian D. Gillmore, Marianna Fontana   +4 more
wiley   +1 more source

Hormone affinity and fibril formation of piscine transthyretin: the role of the N-terminal [PDF]

, 2008
Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates. TH-binding sites are highly conserved in vertebrate TTR however, piscine TTR has a longer N-terminus which is thought to ...
A. Elisabeth Sauer-Eriksson, Achen, Adamski-Werner, Aldred, Almeida, Bendtsen, Benson, Birnboim, Blake, Blake, Blake, Blay, Chang, Chanoine, Colon, Damas, Davis, Deborah M. Power, Dickson, Duan, Duan, Eduardo P. Melo, Eneqvist, Eneqvist, Erik Lundberg, Folli, Hamberger, Hamers, Hamilton, Hammarstrom, Hammarstrom, Hanahan, Harms, Hennebry, Hennebry, Ingenbleek, Isabel Morgado, Karlsson, Klabunde, Lai, Larsson, Layne, Lowry, Lundberg, Manzon, Miroy, Mita, Morais-de-Sa, Naiki, Nielsen, Nídia L. Estrela, Ornstein, Power, Prapunpoj, Prapunpoj, Prapunpoj, Purkey, Quintas, Richardson, Richardson, Richardson, Santos, Santos, Schreiber, Schreiber, Sipe, Southwell, Sunde, Valkonen, Wojtczak, Wojtczak, Wojtczak, Wojtczak, Yamauchi, Yamauchi   +74 more
core   +3 more sources