Results 101 to 110 of about 60,909 (346)
Hormone affinity and fibril formation of piscine transthyretin: the role of the N-terminal [PDF]
, 2008 Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates. TH-binding sites are highly conserved in vertebrate TTR however, piscine TTR has a longer N-terminus which is thought to ...
A. Elisabeth Sauer-Eriksson +74 more
core +3 more sources
Circulation: Heart Failure, 2019 Cardiomyopathy is a manifestation of transthyretin amyloidosis (ATTR), which is an underrecognized systemic disease whereby the transthyretin protein misfolds to form fibrils that deposit in various tissues and organs.
M. Maurer +14 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang +14 more
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is commonly diagnosed in older adults, in particular the wild-type (ATTRwt), which is regarded as an age-related disease.
Biobelemoye Irabor +4 more
doaj +1 more source
Differences in transcription between free-living and CO_2-activated third-stage larvae of Haemonchus contortus [PDF]
, 2010 Background: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide. The infective third-stage larva (L3) of this gastric nematode is enclosed in a cuticle (sheath) and, once
Aleman-Meza, Boanerges +11 more
core +6 more sources
Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis
Nature Communications, 2022 Wild type transthyretin-derived amyloid (ATTRwt) is the major component of non-hereditary transthyretin amyloidosis. Its accumulation in the heart of elderly patients is life threatening.
Maximilian Steinebrei +6 more
semanticscholar +1 more source
Advanced Materials Technologies, EarlyView.Hydrogel‐forming microneedle patches are developed using shape‐preserving PVA‐PVP hydrogels, with and without chitosan, for minimally invasive transdermal protein biomarker sampling. The optimised patches enable efficient interstitial fluid uptake and proteomic analysis, while minimising interference.
Achmad Himawan +12 more
wiley +1 more source
The transthyretin cDNA sequence is normal in transthyretin‐derived senile systemic amyloidosis [PDF]
FEBS Letters, 1991 A variety of mutations leading to amino acid substitutions have been described in the transthyretin gene in association with different familial amyloidoses and have been implicated to be involved in the pathogenesis of amyloid deposits. However, there has been disagreement whether or not a transthyretin mutation is present in the most common form of ...
Per Westermark +5 more
openaire +3 more sources
Biomedicines, 2021 Background: Accumulations of stressful life events result in the onset of major depressive disorder (MDD). Comprehensive genomic analysis is required to elucidate pathophysiological changes and identify applicable biomarkers.
Sung-Liang Yu +5 more
doaj +1 more source
Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease [PDF]
, 2012 Transthyretin (TTR) protects against A-Beta toxicity by binding the peptide thus inhibiting its aggregation. Previous work showed different TTR mutations interact differently with A-Beta, with increasing affinities correlating with decreasing ...
Cardoso, Isabel +2 more
core +2 more sources