Results 111 to 120 of about 60,909 (346)

Chemical Approaches for Array Based Detection of Amyloids

Advanced Sensor Research, EarlyView.
Amyloids are protein aggregates with both pathological and functional roles. Their detection is challenged by structural polymorphism, isoform diversity, and dynamic aggregation behavior. This review presents chemical array‐based sensing strategies that address these complexities, emphasizing fluorescence and colorimetric methods, alongside ...
Paulo M. Simon, Yijia Xu, Amandeep Kaur
wiley   +1 more source

Rare variant (p.Ser43Asn) of familial transthyretin amyloidosis associated with isolated cardiac phenotype: A case series with literature review

Molecular Genetics & Genomic Medicine, 2021
Background p.Ser43Asn is a very rare transthyretin (TTR) mutation leading to familial amyloidosis of transthyretin type, ATTR amyloidosis. It was previously observed in four patients worldwide and is associated almost invariably with an isolated cardiac ...
Maria Papathanasiou, Alexander Carpinteiro, David Kersting, Aiste‐Monika Jakstaite, Tim Hagenacker, Thomas‐Wilfried Schlosser, Christoph Rischpler, Tienush Rassaf, Peter Luedike   +8 more
doaj   +1 more source

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

Frontiers in Cardiovascular Medicine, 2022
BackgroundAmyloidosis refers to an etiologically heterogeneous group of protein misfolding diseases characterized by extracellular deposition in organs and tissues of amyloid fibers, leading to severe organ dysfunction and death.
Pinchao Lv, Yuxi Li, Lin Wu, Qiuping Shi, Lingchao Meng, Xiaojuan Yu, Lin Nong, Jianping Li   +7 more
doaj   +1 more source

Diflunisal treatment is associated with improved survival for patients with early stage wild-type transthyretin (ATTR) amyloid cardiomyopathy: the Boston University Amyloidosis Center experience

Amyloid: Journal of Protein Folding Disorders, 2022
Background Diflunisal is a non-steroidal anti-inflammatory drug that stabilises transthyretin (TTR) and reduces neurologic deterioration in patients with polyneuropathy caused by hereditary transthyretin amyloidosis (ATTRv).
O. Siddiqi, Y. Mints, J. Berk, L. Connors, G. Doros, D. Gopal, Shivangi Kataria, G. Lohrmann, Alexandra Pipilas, F. Ruberg   +9 more
semanticscholar   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Prevalence, characteristics, and mortality of patients with transthyretin amyloid cardiomyopathy in the Nordic countries

ESC Heart Failure, 2022
Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a progressive condition caused by deposition of transthyretin amyloid fibrils in the heart and is associated with poor quality of life and a shortened lifespan. This study aimed to describe the prevalence,
R. Lauppe, J. Liseth Hansen, A. Fornwall, K. Johansson, Mark H Rozenbaum, A. M. Strand, M. Väkeväinen, J. Kuusisto, E. Gude, J. G. Smith, F. Gustafsson   +10 more
semanticscholar   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

Advanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam, Stephanie Watson, Yogambha Ramaswamy, Gurvinder Singh   +3 more
wiley   +1 more source

ATTR Epidemiology, Genetics, and Prognostic Factors

Methodist DeBakey Cardiovascular Journal, 2022
Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed disease and an underestimated cause of both heart failure and conduction abnormalities.
Chukwuemeka A. Obi, William C. Mostertz, Jan M. Griffin, Daniel P. Judge   +3 more
doaj   +1 more source

Bioelectrical Impedance Analysis (BIA)-derived Phase Angle (PA) is a practical aid to nutritional assessment in hospital in-patients [PDF]

, 2019
Background: Nutritional status can be difficult to assess. Bioelectrical impedance analysis (BIA)-derived phase angle (PA), and the plasma markers citrulline and transthyretin (pre-albumin) have the potential to assist, but the protocol of fasting and ...
Alexandre, L, Chan, WY, Dutton, J, Forbes, A, Morris, P, Player, EL, Tang, J, Thomas, T, Vyas, R   +8 more
core   +1 more source