Results 121 to 130 of about 45,139 (271)

Taxonomy of Chemical Bondings: Opportunities and Challenges

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
The recent focus on supramolecular and nanosized systems produced a major increase in the types of observed noncovalent interactions and in the diversity of terms used to designate them. A hierarchical categorization (taxonomy) of terms used to designate electrophile···nucleophile interactions is proposed here.
Andrea Pizzi, Giancarlo Terraneo, Cristina Lo Iacono, Roberta Beccaria, Arun Dhaka, Giuseppe Resnati   +5 more
wiley   +2 more sources

Quantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats

PROTEOMICS, EarlyView.
ABSTRACT The cochlea, an incredibly sensitive sensory system, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may impair hearing.
Motahare Khorrami, Paul A. Haynes, Christopher Pastras, Mohsen Asadnia   +3 more
wiley   +1 more source

Is Transthyretin a Regulator of Ubc9 SUMOylation?

PLOS ONE, 2016
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylation of TTR.
Elżbieta Wieczorek, Sylwia Kędracka–Krok, Katarzyna Sołtys, Urszula Jankowska, Rafał Hołubowicz, Justyna Seliga, Andrzej Ożyhar   +6 more
openaire   +6 more sources

Subthreshold Aortic Valve Calcium Scores in Severe Aortic Stenosis and Transthyretin Cardiac Amyloidosis

JACC: Case Reports, 2020
We have clinically observed that some patients with transthyretin cardiac amyloidosis and severe aortic stenosis may have lesser degrees of calcification than one might expect.
Muzna Hussain, MD, Mazen Hanna, MD, Leonardo Rodriguez, MD, Brian Griffin, MD, Chris Watson, MD PhD, Dermot Phelan, MD, Paul Schoenhagen, MD, Wael Jaber, MD, Paul Cremer, MD, Patrick Collier, MD, PhD   +9 more
doaj  

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Corino de Andrade disease: mechanisms and impact on reproduction [PDF]

, 2017
Familial amyloid polyneuropathy was first described by Corino de Andrade in 1952 in Northern Portugal. It is a fatal autosomal dominant neurodegenerative disorder characterized by a progression of neurologic symptoms, beginning early in the reproductive ...
Barros, A., Coelho, T., Lopes, R., Sousa, M.   +3 more
core   +1 more source

Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis

Drug Design, Development and Therapy, 2019
Veena Mathew,1 Annabel K Wang1,2 1Department of Neurology, UCI ALS and Neuromuscular Center, University of California, Irvine, Orange, CA, USA; 2Neurology Section, Tibor Rubin VA Medical Center, Long Beach, CA, USA Abstract: Hereditary transthyretin ...
Mathew V, Wang AK
doaj  

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

Frontiers in Cellular Neuroscience, 2015
Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), likely contribute to complications of Alzheimer’s disease ...
Ibrahim eGonzález Marrero, Lydia eGiménez Llort, Conrad E. eJohanson, Emilia María eCarmona Calero, Leandro eCastañeyra Ruiz, José Miguel eBrito Armas, Agustín eCastañeyra Perdomo, Rafael eCastro-Fuentes   +7 more
doaj   +1 more source

Brain‐specific expression of transthyretin mRNA as revealed by cDNA cloning from brain [PDF]

, 1989
Kiyoto Motojima, Sataro Goto
openalex   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source