Results 21 to 30 of about 21,795 (202)

A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

EMBO Molecular Medicine, 2015
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing
Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti   +17 more
doaj   +1 more source

The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker

Frontiers in Physiology, 2019
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body.
Meesha Sharma, Sheeza Khan, Safikur Rahman, Laishram Rajendrakumar Singh   +3 more
doaj   +1 more source

Specific Therapy for Transthyretin Cardiac Amyloidosis: A Systematic Literature Review and Evidence‐Based Recommendations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The emergence of specific therapies for transthyretin cardiac amyloidosis (CA) warrants the need for a systematic review of the literature.
Nuno Marques, Olga Azevedo, Ana Rita Almeida, Dina Bento, Inês Cruz, Emanuel Correia, Carolina Lourenço, Luís Rocha Lopes   +7 more
doaj   +1 more source

Proteomic analysis of plasma proteins of high-flux haemodialysis and on-line haemodiafiltration patients reveals differences in transthyretin levels related with anaemia

Scientific Reports, 2020
A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO).
Emma Martínez-Alonso, Paula Alcázar, Emilio Camafeita, Milagros Fernández-Lucas, Gloria Ruíz-Roso, Alberto Alcázar   +5 more
doaj   +1 more source

Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology

Annals of Medicine, 2021
Background Hereditary Transthyretin-Related Amyloidosis, a clinically heterogeneous autosomal dominant disease caused by pathogenic variants in the TTR gene, is characterized by the deposition of insoluble misfolded protein fibrils.
Volha Skrahina, Ulrike Grittner, Christian Beetz, Thomas Skripuletz, Martin Juenemann, Heidrun H. Krämer, Katrin Hahn, Andreas Rieth, Volker Schaechinger, Monica Patten, Christian Tanislav, Stephan Achenbach, Birgit Assmus, Fabian Knebel, Stefan Gingele, Aliaksandr Skrahin, Jörg Hartkamp, Toni M. Förster, Sabine Roesner, Catarina Pereira, Arndt Rolfs   +20 more
doaj   +1 more source

Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report

Journal of Medical Case Reports, 2017
Background Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.
Benjamin Terrier, Magali Colombat, Caroline Beugnet, Astrid Quéant, Jonathan London, Jean-Baptiste Daudin, Claire Le Jeunne, Luc Mouthon, Dominique Monnet, Cécile Cauquil, Catherine Lacroix, David Adams, Antoine Brézin, Sophie Valleix   +13 more
doaj   +1 more source

A machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy

Nature Communications, 2021
Transthyretin amyloid cardiomyopathy is a treatable but often unrecognized cause of heart failure. We derived and validated a machine learning model based on medical diagnostic codes that identifies heart failure patients at risk for wild-type ...
Ahsan Huda, Adam Castaño, Anindita Niyogi, Jennifer Schumacher, Michelle Stewart, Marianna Bruno, Mo Hu, Faraz S. Ahmad, Rahul C. Deo, Sanjiv J. Shah   +9 more
doaj   +1 more source

Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis [PDF]

The FEBS Journal, 2009
Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins.
openaire   +2 more sources

Management of transthyretin amyloidosis

Swiss medical weekly, 2021
Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR
Condoluci, Adalgisa, Théaudin, Marie, Schwotzer, Rahel, Pazhenkottil, Aju P, Arosio, Paolo, Averaimo, Manuela, Bacher, Ulrike, Bode, Peter, Cavalli, Andrea, Dirnhofer, Stefan, Djerbi, Nadia, Dobner, Stephan, Fehr, Thomas, Garofalo, Maura, Gaspert, Ariana, Gerull, Sabine, Heimgartner, Raphael, Hübers, Annemarie, Jung, Hans H, Kessler, Chiara, Knöpfel, Raphael, Laptseva, Natallia, Magini, Giulia, Manka, Robert, Mazzucchelli, Luca, Meyer, Martin, Mihaylova, Violeta, Monney, Pierre, Mylonas, Alessio, Nkoulou, René, Pabst, Thomas, Pfister, Otmar, Rüfer, Axel, Schmidt, Adrian, Seeger, Harald, Stämpfli, Simon F, Stirnimann, Guido, Suter, Thomas, Treglia, Giorgio, Tzankov, Alexandar, Vetter, Friederike, Zweier, Markus, Flammer, Andreas J, Gerber, Bernhard   +43 more
openaire   +5 more sources

Genotype-Phenotype Correlation of a Rare Transthyretin Variant Causing AmyloidosisNovel Teaching Points

CJC Open, 2022
Left ventricular hypertrophy is a common entity with a broad differential diagnosis. We present a case of a middle-aged woman with left ventricular hypertrophy and neuropathy caused by a rare transthyretin variant in the absence of a family history or ...
Ammar G. Chaudhary, MBChB, FRCPC, Fadi M. AlReefi, MD, Riad G. Abou Zahr, MD, FSCMR, Hossam A. Elzeftawy, MD, Saleh S. Alghamdi, MD, Areej A. Bushnag, MD, Jaudah A. Al-Maghrabi, MD, MSc, FRCPC, Iman S. Abumansour, MD   +7 more
doaj   +1 more source