Results 21 to 30 of about 29,341 (237)
A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
EMBO Molecular Medicine, 2015 The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing
Julien Marcoux +17 more
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Hereditary transthyretin amyloidosis
Нервно-мышечные болезни, 2020 Hereditary transthyretin amyloidosis is described in this review, including the TTR gene structure and mutation spectrum, the transthyretin protein structure and functions, the main clinical manifestations of transthyretin amyloidosis.
T. A. Adyan, A. V. Polyakov
doaj +1 more source
The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker
Frontiers in Physiology, 2019 The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body.
Meesha Sharma +3 more
doaj +1 more source
Scientific Reports, 2020 A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO).
Emma Martínez-Alonso +5 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background The emergence of specific therapies for transthyretin cardiac amyloidosis (CA) warrants the need for a systematic review of the literature.
Nuno Marques +7 more
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Annals of Medicine, 2021 Background Hereditary Transthyretin-Related Amyloidosis, a clinically heterogeneous autosomal dominant disease caused by pathogenic variants in the TTR gene, is characterized by the deposition of insoluble misfolded protein fibrils.
Volha Skrahina +20 more
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Journal of Medical Case Reports, 2017 Background Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.
Benjamin Terrier +13 more
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Genetic and Clinical Spectrum of Hereditary Transthyretin Amyloidosis in Brazil. [PDF]
J Peripher Nerv SystABSTRACT Background Transthyretin hereditary amyloidosis (ATTRv) clinical variability has been widely reported, not only across countries and variants but also among families and distinct regions within a single nation. One of the principal challenges in disease management is the accurate determination of age of onset (AOO), which is heterogeneous and ...
Maximiano-Alves G +10 more
europepmc +2 more sources
Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis [PDF]
The FEBS Journal, 2009 Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins.
openaire +2 more sources
Management of transthyretin amyloidosis
Swiss medical weekly, 2021 Transthyretin amyloidosis (ATTR amyloidosis) is a disease caused by deposition of transthyretin fibrils in organs and tissues, which causes their dysfunction. The clinical heterogeneity of ATTR amyloidosis and the variable presentation of symptoms at early disease stages, historically meant treatment delays. Diagnostic tools and therapy options of ATTR
Condoluci, Adalgisa +43 more
openaire +5 more sources