Results 51 to 60 of about 45,139 (271)
Frontiers in Molecular Biosciences, 2021 Monomer dissociation and subsequent misfolding of the transthyretin (TTR) is one of the most critical causative factors of TTR amyloidosis. TTR amyloidosis causes several human diseases, such as senile systemic amyloidosis and familial amyloid ...
Wonjin Yang +9 more
doaj +1 more source
Transthyretin familial amyloid polyneuropathy impact on health-related quality of life [PDF]
, 2015 info:eu-repo/semantics ...
Carvalho, M. +5 more
core +2 more sources
Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation
Frontiers in Cell and Developmental Biology, 2021 Transthyretin (TTR), a plasma and cerebrospinal fluid protein, increases axon growth and organelle transport in sensory neurons. While neurons extend their axons, the microtubule (MT) cytoskeleton is crucial for the segregation of functional compartments
Jessica Eira +9 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Hereditary (variant) transthyretin amyloidosis (ATTRv amyloidosis), which is caused by variants in the transthyretin (TTR) gene, leads to TTR amyloid deposits in multiple organs and various symptoms such as limb ataxia, muscle weakness, and cardiac failure.
Hiroki Yamaguchi +14 more
openaire +3 more sources
Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]
, 2012 Peer reviewedPublisher ...
Agouni, Abdelali +3 more
core +3 more sources
Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis [PDF]
Laboratory Investigation, 2013 Transthyretin (TTR)-related amyloidosis is a fatal disorder characterized by systemic extracellular deposition of TTR amyloid fibrils. Mutations in the TTR gene cause an autosomal dominant form of the disease-familial amyloidotic polyneuropathy (FAP). Wild-type (WT) TTR can also form amyloid fibrils in elderly patients with senile systemic amyloidosis.
Yukio Ando +5 more
openaire +4 more sources
European Journal of Heart Failure, 2022 AbstractAimsTransthyretin amyloid cardiomyopathy (ATTR‐CM) is increasingly recognized as a cause of heart failure in the elderly. Although wild‐type transthyretin amyloidosis is the most frequent form of ATTR‐CM found in the elderly, hereditary transthyretin amyloidosis (ATTRv) can also occur.
Maestro Benedicto, Alba +13 more
openaire +6 more sources
Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
Advanced Functional Materials, EarlyView.This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer +10 more
wiley +1 more source
, 2021 Evolution of the amino acid sequences of transthyretin (TTR) can provide additional information about its dynamics that both complements and extends the already extensive static structural data. Protein dynamics is largely driven by interactions between the protein itself and the thin water film that covers it.
openaire +2 more sources
Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]
, 2011 Peer reviewedPublisher ...
Campbell, Fiona Margaret +9 more
core +4 more sources