Results 51 to 60 of about 60,909 (346)

Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy

Journal of the American College of Cardiology, 2019
Transthyretin (TTR) amyloidosis is an underdiagnosed disease caused by destabilization of TTR due to pathogenic mutations or aging. Both pathogenic and protective mutations illuminate mechanisms of disease and potential interventions. AG10 is a selective, oral TTR stabilizer under development for transthyretin amyloidosis cardiomyopathy (ATTR-CM) that ...
Van N. Selby, Cameron W. Turtle, Ronald M. Witteles, Martha Grogan, Daniel Jacoby, Mathew S. Maurer, Jignesh Patel, Daniel P. Judge, Jonathan C. Fox, Mazen Hanna, Uma Sinha, Rodney H. Falk, Sanjiv J. Shah, Satish Rao, Jose Nativi-Nicolau, Stephen B. Heitner   +15 more
openaire   +3 more sources

The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker

Frontiers in Physiology, 2019
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body.
Meesha Sharma, Sheeza Khan, Safikur Rahman, Laishram Rajendrakumar Singh   +3 more
doaj   +1 more source

Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology

Annals of Medicine, 2021
Background Hereditary Transthyretin-Related Amyloidosis, a clinically heterogeneous autosomal dominant disease caused by pathogenic variants in the TTR gene, is characterized by the deposition of insoluble misfolded protein fibrils.
Volha Skrahina, Ulrike Grittner, Christian Beetz, Thomas Skripuletz, Martin Juenemann, Heidrun H. Krämer, Katrin Hahn, Andreas Rieth, Volker Schaechinger, Monica Patten, Christian Tanislav, Stephan Achenbach, Birgit Assmus, Fabian Knebel, Stefan Gingele, Aliaksandr Skrahin, Jörg Hartkamp, Toni M. Förster, Sabine Roesner, Catarina Pereira, Arndt Rolfs   +20 more
doaj   +1 more source

Klotho controls the brain-immune system interface in the choroid plexus. [PDF]

, 2018
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn, Kim, Daniel, Larsson, Tobias E, Mucke, Lennart, Stein, Liana R, Yu, Gui-Qiu, Zhan, Lihong, Zhu, Lei   +7 more
core   +1 more source

Proteomic analysis of plasma proteins of high-flux haemodialysis and on-line haemodiafiltration patients reveals differences in transthyretin levels related with anaemia

Scientific Reports, 2020
A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO).
Emma Martínez-Alonso, Paula Alcázar, Emilio Camafeita, Milagros Fernández-Lucas, Gloria Ruíz-Roso, Alberto Alcázar   +5 more
doaj   +1 more source

Sixty years of experience with hereditary transthyretin amyloidosis: Insights from the Swedish transthyretin amyloidosis registry. [PDF]

J Intern Med
Abstract Background Hereditary transthyretin (ATTRv) amyloidosis was first described in Sweden in the late 1960s. Selected patient data have been collected since then and have now been transferred to a national quality registry. Methods This is the first report from SveATTR—a longitudinal Swedish web‐based registry open for TTR variant carriers and ...
Stenberg L, Pilebro B, Anan I, Baranda JM, Samuelsson K, Eldhagen P, Backlund R, Wixner J.   +7 more
europepmc   +2 more sources

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]

, 2012
Peer reviewedPublisher ...
Agouni, Abdelali, Delibegovic, Mirela, Hoggard, Nigel, Mody, Nimesh   +3 more
core   +3 more sources

Transthyretin cardiac amyloidosis.

Medicine and pharmacy reports, 2021
Transthyretin amyloid cardiomyopathy (ATTR-CM) may be an under recognized cause of heart failure (HF). TTR amyloidosis can be inherited, caused by variants in the TTR gene (ATTRv) or by deposition of wild-type TTR protein (ATTRwt), leading to high mortality if untreated.
Ioan Alexandru Minciună, Ruxandra Beyer, Raluca Tomoaia, Alina Chirilă, Dana Pop, Alexandra Dădârlat-Pop, Simona Manole   +6 more
openaire   +3 more sources

Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report

Journal of Medical Case Reports, 2017
Background Hereditary transthyretin amyloidosis is an autosomal dominant inherited disorder, first described in families with sensorimotor and autonomic neuropathy.
Benjamin Terrier, Magali Colombat, Caroline Beugnet, Astrid Quéant, Jonathan London, Jean-Baptiste Daudin, Claire Le Jeunne, Luc Mouthon, Dominique Monnet, Cécile Cauquil, Catherine Lacroix, David Adams, Antoine Brézin, Sophie Valleix   +13 more
doaj   +1 more source

Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]

, 2011
Peer reviewedPublisher ...
Campbell, Fiona Margaret, Carpintero, Rakel, Eckersall, P. David, Gruys, Erik, Heegaard, Peter M. H., Lampreave, Fermin, Piñeiro, Matilde, Skall Sorensen, Nanna, Stockmarr, Anders, Toussaint, Mathilda J.M.   +9 more
core   +4 more sources