Results 81 to 90 of about 60,909 (346)

Early Progression of Aortic Stenosis Associated With Iatrogenic Variant Transthyretin Amyloidosis After Domino Liver Transplantation

JACC: Case Reports, 2020
We report a 65-year-old man who underwent aortic valve replacement because of severe aortic stenosis associated with de novo iatrogenic variant transthyretin amyloidosis derived from a liver graft extracted from a patient with hereditary transthyretin ...
Yasuhito Hosoda, MD, Mitsuharu Ueda, MD, PhD, Jun Takaki, MD, Ken Okamoto, MD, PhD, Taro Yamashita, MD, PhD, Toshihiro Fukui, MD, PhD   +5 more
doaj   +1 more source

Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis [PDF]

, 2006
BACKGROUND: Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs.
Bahn, Sabine, Gerth, Christoph W., Gross, Sonja, Harris, Nathan, Huang, Jeffrey T.J., Koethe, Dagmar, Leweke, F. Markus, Nolden, Brit M., Oxley, David, Reed, Benjamin, Schreiber, Daniela, Wang, Lan   +11 more
core   +4 more sources

Sex differences among patients with transthyretin amyloid cardiomyopathy – from diagnosis to prognosis

European Journal of Heart Failure, 2022
Transthyretin amyloid cardiomyopathy (ATTR‐CM) is predominantly diagnosed in men. The few available studies suggest affected women have a more favourable cardiac phenotype.
R. Patel, A. Ioannou, Y. Razvi, L. Chacko, L. Venneri, F. Bandera, D. Knight, T. Kotecha, A. Martinez-Naharro, A. Masi, A. Porcari, James T Brown, Kiara N Patel, C. Manisty, J. Moon, D. Rowczenio, J. Gilbertson, G. Sinagra, H. Lachmann, A. Wechalekar, A. Petrie, C. Whelan, P. Hawkins, J. Gillmore, M. Fontana   +24 more
semanticscholar   +1 more source

Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis [PDF]

Laboratory Investigation, 2013
Transthyretin (TTR)-related amyloidosis is a fatal disorder characterized by systemic extracellular deposition of TTR amyloid fibrils. Mutations in the TTR gene cause an autosomal dominant form of the disease-familial amyloidotic polyneuropathy (FAP). Wild-type (WT) TTR can also form amyloid fibrils in elderly patients with senile systemic amyloidosis.
Yukio Ando, Nádia Gonçalves, Nádia Gonçalves, Maria João Saraiva, Maria João Saraiva, Yohei Misumi   +5 more
openaire   +4 more sources

The yeast molecular chaperone, Hsp104, influences transthyretin aggregate formation

Frontiers in Molecular Neuroscience, 2022
Patients with the fatal disorder Transthyretin Amyloidosis (ATTR) experience polyneuropathy through the progressive destruction of peripheral nervous tissue.
Adam S. Knier, Emily E. Davis, Hannah E. Buchholz, Jane E. Dorweiler, Lauryn E. Flannagan, Anita L. Manogaran   +5 more
doaj   +1 more source

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein [PDF]

, 2016
Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals.
Biasini, Emiliano, Borsello, Tiziana, Castilla, Joaqu\uedn, Cerovic, Milica, Cimini, Sara, Elezgarai, Saioa R., Gobbi, Marco, Massignan, Tania, Moreno, Jorge, Negro, Alessandro, Nonno, Romolo, Restelli, Elena, Riccardi, Geraldina, Sangiovanni, Valeria, Stincardini, Claudia, Stravalaci, Matteo, Vanni, Ilaria   +16 more
core   +2 more sources

Impact of vutrisiran on exploratory cardiac parameters in hereditary transthyretin‐mediated amyloidosis with polyneuropathy

European Journal of Heart Failure
HELIOS‐A was a Phase 3, open‐label study of vutrisiran, an RNA interference therapeutic, in patients with hereditary transthyretin (ATTRv) amyloidosis with polyneuropathy.
P. García-Pavía, M. Grogan, P. Kale, J. Berk, M. S. Maurer, I. Conceição, Marcelo F Di Carli, S. Solomon, Chongshu Chen, E. Yureneva, J. Vest, J. Gillmore   +11 more
semanticscholar   +1 more source

The Journey of Human Transthyretin: Synthesis, Structure Stability, and Catabolism

Biomedicines, 2022
Transthyretin (TTR) is a homotetrameric protein mainly synthesised by the liver and the choroid plexus whose function is to carry the thyroid hormone thyroxine and the retinol-binding protein bound to retinol in plasma and cerebrospinal fluid.
C. Sanguinetti, M. Minniti, Vanessa Susini, L. Caponi, G. Panichella, V. Castiglione, A. Aimo, M. Emdin, G. Vergaro, M. Franzini   +9 more
semanticscholar   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Evolution of Transthyretin

, 2021
Evolution of the amino acid sequences of transthyretin (TTR) can provide additional information about its dynamics that both complements and extends the already extensive static structural data. Protein dynamics is largely driven by interactions between the protein itself and the thin water film that covers it.
openaire   +2 more sources