Results 81 to 90 of about 61,872 (307)

Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction.

JAMA cardiology, 2021
Importance Heart failure (HF) with preserved ejection fraction (HFpEF) is common, is frequently associated with ventricular wall thickening, and has no effective therapy.
O. AbouEzzeddine, Daniel R Davies, C. Scott, A. Fayyaz, J. Askew, P. McKie, P. Noseworthy, G. Johnson, S. Dunlay, B. Borlaug, P. Chareonthaitawee, V. Roger, A. Dispenzieri, M. Grogan, M. Redfield   +14 more
semanticscholar   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Subthreshold Aortic Valve Calcium Scores in Severe Aortic Stenosis and Transthyretin Cardiac Amyloidosis

JACC: Case Reports, 2020
We have clinically observed that some patients with transthyretin cardiac amyloidosis and severe aortic stenosis may have lesser degrees of calcification than one might expect.
Muzna Hussain, MD, Mazen Hanna, MD, Leonardo Rodriguez, MD, Brian Griffin, MD, Chris Watson, MD PhD, Dermot Phelan, MD, Paul Schoenhagen, MD, Wael Jaber, MD, Paul Cremer, MD, Patrick Collier, MD, PhD   +9 more
doaj   +1 more source

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein [PDF]

, 2016
Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals.
Biasini, Emiliano, Borsello, Tiziana, Castilla, Joaqu\uedn, Cerovic, Milica, Cimini, Sara, Elezgarai, Saioa R., Gobbi, Marco, Massignan, Tania, Moreno, Jorge, Negro, Alessandro, Nonno, Romolo, Restelli, Elena, Riccardi, Geraldina, Sangiovanni, Valeria, Stincardini, Claudia, Stravalaci, Matteo, Vanni, Ilaria   +16 more
core   +2 more sources

Systemic embolism in amyloid transthyretin cardiomyopathy

European Journal of Heart Failure, 2022
Although systemic embolism is a potential complication in transthyretin amyloid cardiomyopathy (ATTR‐CM), data about its incidence and prevalence are scarce.
S. Vilches, M. Fontana, E. Gonzalez-Lopez, L. Mitrani, G. Saturi, Mary Renju, J. Griffin, A. Caponetti, S. Gnanasampanthan, Jeffeny De los Santos, C. Gagliardi, A. Rivas, F. Domínguez, S. Longhi, C. Rapezzi, M. Maurer, J. Gillmore, P. García-Pavía   +17 more
semanticscholar   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Amyloid Transthyretin Cardiomyopathy in Elderly Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The prevalence of calcific aortic stenosis and amyloid transthyretin cardiomyopathy (ATTR‐CM) increase with age, and they often coexist. The objective was to determine the prevalence of ATTR‐CM in patients with severe aortic stenosis and ...
Stephan Dobner, Thomas Pilgrim, Daniel Hagemeyer, Dik Heg, Jonas Lanz, Nicole Reusser, Christoph Gräni, Ali Afshar‐Oromieh, Axel Rominger, Bettina Langhammer, David Reineke, Stephan Windecker, Stefan Stortecky   +12 more
doaj   +1 more source

Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis [PDF]

, 2006
BACKGROUND: Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional beliefs.
Bahn, Sabine, Gerth, Christoph W., Gross, Sonja, Harris, Nathan, Huang, Jeffrey T.J., Koethe, Dagmar, Leweke, F. Markus, Nolden, Brit M., Oxley, David, Reed, Benjamin, Schreiber, Daniela, Wang, Lan   +11 more
core   +4 more sources

Clinical and genetic profile of patients enrolled in the Transthyretin Amyloidosis Outcomes Survey (THAOS): 14-year update

Orphanet Journal of Rare Diseases, 2022
Background Transthyretin amyloidosis (ATTR amyloidosis) is a rare, life-threatening disease caused by the accumulation of variant or wild-type (ATTRwt amyloidosis) transthyretin amyloid fibrils in the heart, peripheral nerves, and other tissues and ...
A. Dispenzieri, T. Coelho, I. Conceição, M. Waddington-Cruz, J. Wixner, A. Kristen, C. Rapezzi, V. Planté-Bordeneuve, J. González-Moreno, M. Maurer, M. Grogan, Doug Chapman, L. Amass, Pablo Garcia Ivaylo Jose Gonzalez Maria Alejandra Gonzal Pavia Tarnev Costello Briseno Schmidt Drachman Bar, P. G. Pavía, Ivaylo Tarnev, J. Costello, Maria Alejandra González-Duarte Briseño, H. Schmidt, B. Drachman, F. Barroso, T. Yamashita, O. Lairez, Y. Sekijima, G. Vita, E. Jeon, M. Hanna, D. Slosky, M. Luigetti, S. Lorusso, F. Beamud, D. Adams, H. Moelgaard, R. Press, C. Cirami, Hans Nienhuis, J. M. Plana, J. Inamo, D. Jacoby, M. Emdin, D. Quan, S. Hummel, R. Witteles, A. Dori, Sanjiv Shah, D. Lenihan, O. Azevedo, S. Murali, S. Živković, S. Low, J. Nativi-Nicolau, N. Fine, J. Tallaj, C. Tschoepe, R. Torrón, M. Polydefkis, G. Merlini, S. Bădeliță, Stephen S. Gottlieb, J. Tauras, E. B. Correia, H. Ventura, B. Gess, F. Darstein, Jeeyoung Oh, Tessa Marburger, J. Van Cleemput, V. Salutto, Y. Parman, C. Chao, N. Sarswat, Christopher Mueller, D. Steidley, J. Ralph, A. Warner, W. Cotts, J. Hoffman, M. Rugiero, S. Misawa, J. L. Blanco, L. G. Dávila, M. Sadeh, Jinju Luo, T. Kyriakides, Annabel K. Wang, H. Kaufmann, S. Živković   +86 more
semanticscholar   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source