Results 91 to 100 of about 7,937 (220)

Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice

JACC: Heart Failure, 2019
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening, progressive, infiltrative disease caused by the deposition of transthyretin amyloid fibrils in the heart, and can often be overlooked as a common cause of heart failure. Delayed diagnosis due to lack of disease awareness and misdiagnosis results in a poorer prognosis.
Witteles R. M., Bokhari S., Damy T., Elliott P. M., Falk R. H., Fine N. M., Gospodinova M., Obici L., Rapezzi C., Garcia-Pavia P.   +9 more
openaire   +6 more sources

Initial Capture Failure With Delayed Resolution in Atrial Leadless Pacemaker Implantation: A Case of ATTR Amyloidosis With Sinus Node Dysfunction

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
ATTR amyloidosis patient with initial atrial capture failure showed delayed threshold improvement over time. Stable current of injury and impedance guided expectant management, avoiding unnecessary device repositioning while achieving successful outcomes.
Yasuyuki Takada, Junichi Kamoshida, Muryo Terasawa, Kazuhiro Satomi, Yoshinao Yazaki   +4 more
wiley   +1 more source

Case Report: Diagnosis of Dual-Biopsy Negative Severe Cardiac Amyloidosis [PDF]

, 2016
INTRODUCTION Amyloidosis is a rare disorder that involves the deposition of misfolded protein in extracellular tissue. Disease manifestations vary depending on the affected organs.
Kasprowicz, MD, Eric, Lohr, MD, Kristin
core   +2 more sources

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases [PDF]

, 2020
Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids.
Alarcón de la Lastra Romero, Catalina, Castejón Martínez, María Luisa, Montoya García, Tatiana, Sánchez Hidalgo, Marina   +3 more
core   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

High profile transvalvular microaxial flow pump as a bridge to heart transplantation for amyloid cardiomyopathy: A case series

JHLT Open
Background: The definitive treatment for end-stage heart failure (ESHF) due to amyloid cardiomyopathy (ACM) is an orthotopic heart transplant (OHT).
Pankaj Garg, MBBS, Mohammad Alomari, MD, Ishaq Wadiwala, MBBS, Melissa Lyle, MD, Si Pham, MD, Nafiye Busra Celik, MD, Juan C. Leoni Moreno, MD, Rohan Goswami, MD, Kevin Landolfo, MD, Jose Nativi-Nicolau, MD, Daniel Yip, MD, Parag C. Patel, MD, Basar Sareyyupoglu, MD   +12 more
doaj   +1 more source

First‐Generation TTR Silencing Therapies in Hereditary Transthyretin Amyloidosis With Polyneuropathy: Real‐World Insights From a German Single‐Referral Center

European Journal of Neurology, Volume 33, Issue 2, February 2026.
Real‐world long‐term treatment with the first‐generation TTR silencers, patisiran and inotersen, in patients with ATTRv‐PN is safe, consistently reducing serum TTR levels, stabilizing neurologic symptoms, cardiac and renal functions, and nutritional parameters.
Marilin S. Koch, Fabian aus dem Siepen, Ute Hegenbart, Stefan Schönland, Markus Weiler   +4 more
wiley   +1 more source

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report

Journal of Medical Case Reports, 2018
Background Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs.
Hiroyuki Yamamoto, Toru Hashimoto, Shunji Kawamura, Michiaki Hiroe, Taro Yamashita, Yukio Ando, Tomoki Yokochi   +6 more
doaj   +1 more source

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells

, 2017
Familial amyloid polyneuropathy (FAP) is caused by mutations of the transthyretin (TTR) gene, predominantly expressed in the liver. Two compounds that knockdown TTR, comprising a small interfering RNA (siRNA; ALN-TTR-02) and an antisense oligonucleotide (
Ackermann, E.J. (Elisabeth), Avsar, Y. (Yesim), Chandhok, G. (Gursimran), Fleischhauer, L. (Lutz), Gollob, J. (Jared), Guo, S. (Shuling), Guttmann, S. (Sarah), Monia, B.P. (Brett), Niemietz, C. (Christoph), Sauer, V.D. (Vanessa), Schmidt, H. (Hartmut), Stella, J. (Jaqueline), Zibert, A. (Andree)   +12 more
core   +1 more source

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein [PDF]

, 2016
Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the central nervous system of affected individuals.
Biasini, Emiliano, Borsello, Tiziana, Castilla, Joaqu\uedn, Cerovic, Milica, Cimini, Sara, Elezgarai, Saioa R., Gobbi, Marco, Massignan, Tania, Moreno, Jorge, Negro, Alessandro, Nonno, Romolo, Restelli, Elena, Riccardi, Geraldina, Sangiovanni, Valeria, Stincardini, Claudia, Stravalaci, Matteo, Vanni, Ilaria   +16 more
core   +2 more sources