Results 1 to 10 of about 1,163,658 (291)

Untargeted 1H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant schizophrenia patients: a pilot study [PDF]

Translational Psychiatry
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population. Despite the availability of antipsychotic therapies, about 30% of patients develop treatment-resistant schizophrenia (TRS), defined by a lack of response to ...
Carmen Marino, Siwei Zhang, Giuseppe De Simone, Manuela Grimaldi, Anna Di Maio, Felice Iasevoli, Francesco Errico, Anna Maria D’Ursi, Andrea de Bartolomeis, Alessandro Usiello   +9 more
doaj   +2 more sources

Cognition in Treatment Resistant versus Non- Treatment Resistant Schizophrenia [PDF]

Eur Psychiatry
IntroductionDespite antipsychotic treatment, around one-third of individuals of schizophrenia remain unresponsive.ObjectivesComparing cognitive impairments in TRS versus non-TRS patients.Methods50 adult patients with schizophrenia(DSM-5) were recruited in this cross-sectional cohort study, categorised into TRS (14) (treatment-resistant schizophrenia ...
Shah S, Patel K, Bhandari A, Porwal A, Lalwani N.   +4 more
europepmc   +3 more sources

Real-world effectiveness and safety of xanomeline and trospium for treatment-resistant schizophrenia in a state hospital system [PDF]

Frontiers in Psychiatry
ObjectiveXanomeline and trospium (XT) is a novel medication for schizophrenia that was approved by the United States (U.S.) Food and Drug Administration (FDA) in September 2024.
Nina Vadiei, Nina Vadiei, Nina Vadiei, M. Lynn Crismon, M. Lynn Crismon   +4 more
doaj   +2 more sources

Therapeutic effect of demethylated hydroxylated phillygenin derivative on Helicobacter pylori infection

Frontiers in Microbiology, 2023
Modifying and transforming natural antibacterial products is a novel idea for developing new efficacious compounds. Phillygenin has an inhibitory effect on H. pylori.
Ru-Jia Li, Ru-Jia Li, Jia-yin Xu, Xue Wang, Li-juan Liao, Xian Wei, Ping Xie, Wen-yan Xu, Zhen-yi Xu, Shuo-hua Xie, Yu-ying Jiang, Liang Huang, Lu-yao Wang, Gan-rong Huang, Yan-Qiang Huang   +14 more
doaj   +1 more source

Dopamine Dynamics and Neurobiology of Non-Response to Antipsychotics, Relevance for Treatment Resistant Schizophrenia: A Systematic Review and Critical Appraisal

Biomedicines, 2023
Treatment resistant schizophrenia (TRS) is characterized by a lack of, or suboptimal response to, antipsychotic agents. The biological underpinnings of this clinical condition are still scarcely understood.
Felice Iasevoli, Camilla Avagliano, Luigi D’Ambrosio, Annarita Barone, Mariateresa Ciccarelli, Giuseppe De Simone, Benedetta Mazza, Licia Vellucci, Andrea de Bartolomeis   +8 more
doaj   +1 more source

Rhamnolipid-assisted black phosphorus nanosheets with efficient isolinderalactone loading against drug resistant Helicobacter pylori

Materials & Design, 2022
Oral administration remains the main treatment for H. pylori infection, but the acidic environment of the stomach, the biofilm and drug resistance of H. pylori severely impair the antibacterial effect of orally clinical drugs.
Yanqiang Huang, Rujia Li, Yuanyuan Dai, Chun Qin, Jikai He, Shixian Yang, Tengqi Wang, Yujie Su, Lizhou Jia, Wei Zhao   +9 more
doaj   +1 more source

Three New Xanthones from Hypericum scabrum and Their Quorum Sensing Inhibitory Activities against Chromobacterium violaceum

Molecules, 2022
Quorum sensing (QS) plays an important role in the production of virulence factors and pathogenicity in pathogenic bacteria and is, therefore, a hopeful target to fight against bacterial infections.
Li-Ping Teng, Hong Zeng, Cai-Yan Yang, He-Bin Wang, Zhong-Bo Zhou   +4 more
doaj   +1 more source

Intranasal esketamine use in bipolar disorder: A case report [PDF]

Mental Health Clinician, 2021
Over the past few years, intranasal esketamine has been FDA-approved for treatment-resistant depression as well as MDD with suicidal ideation. In the clinical trials leading to the recent FDA approvals, subjects with a diagnosis of bipolar disorder were ...
Courtney Skriptshak, PharmD, Ashley Reich, PharmD, BCPS, BCPP   +1 more
doaj   +1 more source

Antipsychotics-Induced Changes in Synaptic Architecture and Functional Connectivity: Translational Implications for Treatment Response and Resistance

Biomedicines, 2022
Schizophrenia is a severe mental illness characterized by alterations in processes that regulate both synaptic plasticity and functional connectivity between brain regions. Antipsychotics are the cornerstone of schizophrenia pharmacological treatment and,
Andrea de Bartolomeis, Giuseppe De Simone, Mariateresa Ciccarelli, Alessia Castiello, Benedetta Mazza, Licia Vellucci, Annarita Barone   +6 more
doaj   +1 more source

The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia

Biomolecules, 2023
Almost 25% of schizophrenia patients suffer from obsessive-compulsive symptoms (OCS) considered a transdiagnostic clinical continuum. The presence of symptoms pertaining to both schizophrenia and obsessive-compulsive disorder (OCD) may complicate ...
Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D’Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomeis   +8 more
doaj   +1 more source