Results 101 to 110 of about 4,239,487 (340)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle

Molecular Metabolism
Objective: Cachexia in chronic kidney disease (CKD) is a wasting syndrome. The futile creatine cycle (FCC) contributes to energy waste in adipocytes. Creatinine is metabolite of creatine.
Jingwen Fang, Xianfen Huang, Chanchan Guo, Ting Chen, Yubing Chen, Xiaobing Yang, Min Zheng, Hanying Ding   +7 more
doaj   +1 more source

Failure in child tooth avulsion treatment: a case report [PDF]

, 2020
Juliana Espindola Silva de Menezes, Robertha Melo Bomfim, Matheus dos Santos Fernandez, Cristiane Costa da Cunha Oliveira, Vanessa dos Santos Viana   +4 more
openalex   +1 more source

Molecular adsorbent recirculating system treatment in patients with post-hepatectomy liver failure: Long-term results of a pilot study [PDF]

, 2022
Stefan Gilg, Ernesto Sparrelid, Jennie Engstrand, Ruth Baumgartner, Greg Nowak, Per Stål, Melroy A. D’Souza, Anders Jansson, Bengt Isaksson, Eduard Jonas, C. Strömberg   +10 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Outcome specific optimal systolic blood pressure targets in high risk patients, balancing cardiovascular benefits, renal risks, and cancer prevention: meta-analysis of randomised controlled trials

BMJ Medicine
Objective To directly compare the efficacy and safety of different intensive systolic blood pressure targets (<120 or <130 mm Hg) versus usual care on cardiovascular and renal outcomes.Design Meta-analysis of randomised controlled trials.Data ...
Yuanyuan Zhang, Yu Huang, Yiwei Zhang, Xianhui Qin, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Fan Fan Hou, Yiting Wu   +8 more
doaj   +1 more source

Successful Treatment with Low-dose Crizotinib in a Patient with <i>ROS1</i>-rearranged Lung Cancer Who Developed Crizotinib-induced Heart Failure

, 2022
Takahiko Hashimoto, Kosuke Takahashi, Sachiko Ota, Nobumasa Okumura, Haruka Kondo, Asuki Fukatsu, Toru Hara   +6 more
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

High Rate of Treatment Failures in Nonimmune Travelers Treated With Artemether-Lumefantrine for UncomplicatedPlasmodium falciparumMalaria in Sweden: Retrospective Comparative Analysis of Effectiveness and Case Series [PDF]

, 2016
Klara Sondén, Katja Wyss, Irina Jovel, Antero Vieira Silva, Anton Pohanka, Muhammad Asghar, Manijeh Vafa Homann, Lars L. Gustafsson, Urban Hellgren, Anna Färnert   +9 more
openalex   +1 more source