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Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells.
Phytomedicine, 2022BACKGROUND Restoring immune homeostasis by targeting the Th17/Treg response is a potentially valuable therapeutic strategy for ulcerative colitis (UC).
Youbao Zhong +8 more
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Treg Cells and Epigenetic Regulation
2021The discovery of the epigenetic regulation of Treg cells, a cell population with fundamental immunoregulatory properties, has shed considerable insights into an understanding of the role of these cells in health and disease. Research over the past several years has shown that the interaction of Treg cells with the gut microbiota are critical not only ...
Joseph A, Bellanti, Dongmei, Li
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Th17 and Treg cells function in SARS‐CoV2 patients compared with healthy controls
Journal of Cellular Physiology, 2020In the course of the coronavirus disease 2019 (COVID‐19), raising and reducing the function of Th17 and Treg cells, respectively, elicit hyperinflammation and disease progression.
A. Sadeghi +12 more
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Nature Immunology, 2009
T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies of T cell development in the thymus, particularly in terms of positive and negative selection. New transgenic mice produced with TCR genes cloned from regulatory T cells show that TCR specificity does 'instruct' regulatory T cell fate, within limits.
Kristin A, Hogquist, Amy E, Moran
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T cell antigen receptor (TCR)-transgenic models have been enormously influential in studies of T cell development in the thymus, particularly in terms of positive and negative selection. New transgenic mice produced with TCR genes cloned from regulatory T cells show that TCR specificity does 'instruct' regulatory T cell fate, within limits.
Kristin A, Hogquist, Amy E, Moran
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CD36 — the Achilles’ heel of Treg cells
Nature Immunology, 2020Regulatory T (Treg) cells suppress antitumor immunity, but Treg cell inhibition has been hampered by a lack of specific targets. CD36 expression by tumor-infiltrating Treg cells may provide a way to specifically target Treg cells in tumors.
Brendan L. Horton, Stefani Spranger
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The history and promise of Treg cells
ImmunityThe seminal discoveries that established the role of regulatory T cells in immunological tolerance were recognized by this year's Nobel Prize in Physiology or Medicine. We present here the unfolding of the Treg story, the players involved at various stages, and the explosive growth of knowledge about this fascinating cell population.
Christophe Benoist +3 more
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Mechanisms of TREG cell adaptation to inflammation
Journal of Leukocyte Biology, 2020Abstract Inflammation is an important defense mechanism. In this complex and dynamic process, drastic changes in the tissue micro-environment play key roles in dictating the nature of the evolving immune response. However, uncontrolled inflammation is detrimental, leading to unwanted cellular damage, loss of physiological functions, and ...
Fernando Alvarez +3 more
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Treg cells in health and autoimmune diseases: New insights from single cell analysis.
Journal of Autoimmunity, 2019Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of regulatory T cells have been described among the various mechanisms, that are important
C. Scheinecker, L. Göschl, M. Bonelli
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Developmental plasticity of Th17 and Treg cells
Current Opinion in Immunology, 2009The emergence of Th17 cells as a distinct subset of effector CD4 T cells has led to a revised model of the adaptive immune system. Whereas the Th1-Th2 paradigm revolutionized our understanding of adaptive immunity by introducing the concept of alternative developmental pathways for naïve CD4 T cells induced by distinct cytokine cues from microbe ...
Yun Kyung, Lee +3 more
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FOXP3 as a master regulator of Treg cells
Nature Reviews Immunology, 2021Shohei Hori recalls the early work that led to the identification of FOXP3 as the master regulator of regulatory T cells.
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