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How to kill Treg cells for immunotherapy

Nature Cancer, 2020
Achieving depletion of regulatory T cells while sparing tumor-specific effector T cells has long remained an elusive goal of immunotherapy. A new study describing the development of an antibody to the cytokine receptor CD25 optimized to ensure depletion of regulatory T cells without blocking binding of the cytokine IL-2 will reinvigorate interest in ...
Gavin I. Ellis, James L. Riley
openaire   +2 more sources

Expansion of Tumor-Associated Treg Cells Upon Disruption of a CTLA-4-Dependent Feedback Loop

Cell, 2021
Shivashankar Othy   +2 more
exaly  

Treg cells

2016
James Badger Wing, Shimon Sakaguchi
openaire   +1 more source

Stem Cell Epigenetics in Medical Therapy

Medical Epigenetics, 2021
Peng Jin, Liqi Shu
exaly  

Treg Cell-Based Therapies: Challenges and Perspectives

Nature Reviews Immunology, 2020
Caroline Raffin, Jeffrey Bluestone
exaly  

Intricacies of TGF-β Signaling in Treg and Th17 Cell Biology

Cellular and Molecular Immunology, 2023
Yisong Wan, Junying Wang
exaly  

Lipid Signalling Enforces Functional Specialization of Treg Cells in Tumours

Nature, 2021
Gustavo Palacios, Jordy Saravia, Hao Shi
exaly  

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