Results 271 to 280 of about 12,132,339 (300)

How to kill Treg cells for immunotherapy

Nature Cancer, 2020
Achieving depletion of regulatory T cells while sparing tumor-specific effector T cells has long remained an elusive goal of immunotherapy. A new study describing the development of an antibody to the cytokine receptor CD25 optimized to ensure depletion of regulatory T cells without blocking binding of the cytokine IL-2 will reinvigorate interest in ...
Gavin I. Ellis, James L. Riley
openaire   +2 more sources

Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder.

Journal of Neuroimmunology, 2019
We aimed in this study to investigate a possible involvement of Th17/Treg cells imbalance in autism spectrum disorders (ASD). Using flowcytometry to determine circulating Th17 and Treg cells percentages, RT- PCR and ELISA for cytokine expression, we ...
Mai Moaaz, S. Youssry, A. Elfatatry, Mohammed A. Abdel Rahman   +3 more
semanticscholar   +1 more source

Single-Cell Transcriptome Analysis of Treg

2022
Regulatory T-cells (Treg) are considerably heterogeneous. Thymically derived Treg (tTreg) are those, which differentiate in the thymus, while peripherally derived Treg (pTreg) differentiate from peripheral mature CD4+ T-cells. These two populations are often identified using markers such as neuropilin-1 and Helios (for tTreg) and ROR-γt (for pTreg) in ...
Benjy Jek Yang, Tan, Masahiro, Ono, Yorifumi, Satou   +2 more
openaire   +2 more sources

Treg Cells in Rheumatoid Arthritis: An Update

Current Rheumatology Reports, 2013
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses to autoantigens. Regulatory CD4(+) T-cells (Tregs) underpin one of the key mechanisms of self-tolerance and are a major focus of study in RA and other autoimmune diseases.
Faye A H, Cooles, John D, Isaacs, Amy E, Anderson   +2 more
openaire   +2 more sources

Remembering Treg cells

Nature Immunology, 2023
openaire   +2 more sources

Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice

Advanced Materials, 2023
Zhenmei Yang, Anning Li, Xinyi Jiang
exaly  

Treg cells

2016
James Badger Wing, Shimon Sakaguchi
openaire   +1 more source

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Nature Immunology, 2020
C. Ferreira, Leandro Barros, Marta Baptista, B. Blankenhaus, A. Barros, Patrícia Figueiredo-Campos, Š. Konjar, A. Lainé, N. Kamenjarin, A. Stojanovic, A. Cerwenka, H. Probst, Julien C. Marie, M. Veldhoen   +13 more
semanticscholar   +1 more source

Lipid signalling enforces functional specialization of Treg cells in tumours

Nature, 2021
Jun Wei, Hao Shi, Wei Su
exaly  

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

Cell Metabolism, 2020
Wei Su, Nicole M Chapman, Jun Wei
exaly