Results 71 to 80 of about 203,023 (389)

Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa

Frontiers in Immunology, 2019
Mammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and complex ...
P. Pandiyan, N. Bhaskaran, Mangge Zou, Elizabeth A Schneider, S. Jayaraman, J. Huehn   +5 more
semanticscholar   +1 more source

Commensal epitopes drive differentiation of colonic Tregs

Science Advances, 2020
Colonic commensal-derived antigens support expansion and differentiation of immunosupressive CD4 T cells. The gut microbiome is the largest source of intrinsic non–self-antigens that are continuously sensed by the immune system but typically do not ...
M. Kuczma, E. Szurek, Anna Cebula, B. Chassaing, Yu-Jin Jung, Sang-Moo Kang, J. Fox, B. Stecher, L. Ignatowicz   +8 more
semanticscholar   +1 more source

Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression

Epigenetics, 2018
IL2RA, a subunit of the high affinity receptor for interleukin-2 (IL2), plays a crucial role in immune homeostasis. Notably, IL2RA expression is induced in CD4+ T cells in response to various stimuli and is constitutive in regulatory T cells (Tregs).
Marie-Pierre Belot, Anne-Laure Castell, Sophie Le Fur, Pierre Bougnères   +3 more
doaj   +1 more source

Tumor inflating lymphocytes. Purification, expanding and cytotoxicity analisys on primary tumor cultures [PDF]

Клиническая практика, 2020
Background. Tumor Infiltrating Lymphocytes (TILs) is one of the most promising sources of autologous cytotoxic T-cells for adoptive immunotherapy, which has already shown high efficiency in the treatment of metastatic melanoma.
G. M. Yusubalieva, S. V. Petrichuk, A. L. Krivoshapkin, A. G. Kedrova, Yu. V. Ivanov, A. G. Vinokurov, A. A. Kalinkin, A. E. Sandjarov, S. V. Kim, A. V. Ponomarev, D. G. Kuptsova, Roman Ischenko, Alexander Troitskiy, V. P. Baklaushev   +13 more
doaj   +1 more source

Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

Frontiers in Immunology, 2020
Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs can provide protection against depigmentation. Ganglioside D3 (GD3) is
Z. Mukhatayev, E. Dellacecca, C. Cosgrove, Rohan S. Shivde, Dinesh Jaishankar, Katherine Pontarolo-Maag, Jonathan M. Eby, Steven W. Henning, Yekaterina O. Ostapchuk, K. Cedercreutz, A. Issanov, S. Mehrotra, Andreas Overbeck, Richard P. Junghans, Joseph R. Leventhal, I. Le Poole   +15 more
semanticscholar   +1 more source

Retinoic acid as a modulator of T cell immunity [PDF]

, 2016
Indexación: Scopus. DOAJ.Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system,
Bono, M.R., Fernandez, D., Flores-Santibañez, F, Rosemblatt, M., Sauma, D., Tejon, G.   +5 more
core   +1 more source

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

PLoS ONE, 2008
Treg based immunotherapy is of great interest to facilitate tolerance in autoimmunity and transplantation. For clinical trials, it is essential to have a clinical grade Treg isolation protocol in accordance with Good Manufacturing Practice (GMP) guidelines.
Peters, J.H., Preijers, F.W.M.B., Woestenenk, R.M., Hilbrands, L.B., Koenen, H.J.P.M., Joosten, I.   +5 more
openaire   +5 more sources

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source

Tregs and transplantation tolerance [PDF]

Journal of Clinical Investigation, 2004
The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes ...
Patrick T, Walsh, Devon K, Taylor, Laurence A, Turka   +2 more
openaire   +4 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source