Results 11 to 20 of about 63,007 (294)

Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study

The Lancet Microbe, 2023
The increasing incidence of syphilis and the limitations of first-line treatment with penicillin, particularly in neurosyphilis, neonatal syphilis, and pregnancy, highlight the need to expand the therapeutic repertoire for effective management of this disease.
Tantalo, Lauren C., Lieberman, Nicole A. P., Pérez Mañá, Clara, Suñer, Clara, Vall Mayans, Marti, Ubals, María, González Beiras, Camila, Rodríguez Gascón, Alicia, Canut Blasco, Andrés, González Candelas, Fernando, Mueller, John, Tapia, Kenneth, Greninger, Alexander L., Giacani, Lorenzo, Mitjà, Oriol   +14 more
openaire   +5 more sources

Quantified Detection of Treponema pallidum DNA by PCR Assays in Urine and Plasma of Syphilis Patients

Microbiology Spectrum, 2022
Treponema pallidum can invade any organ, and T. pallidum DNA can be detected in various tissues and fluids. However, the knowledge of the presence and loads of T. pallidum DNA in urine is limited.
Cuini Wang, Xin Zheng, Zhifang Guan, Danyang Zou, Xin Gu, Haikong Lu, Mei Shi, Pingyu Zhou   +7 more
doaj   +2 more sources

Genetic engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.

PLoS Pathogens, 2021
Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful.
Emily Romeis, Lauren Tantalo, Nicole Lieberman, Quynh Phung, Alex Greninger, Lorenzo Giacani   +5 more
doaj   +2 more sources

Long-Term In Vitro Culture of the Syphilis Spirochete Treponema pallidum subsp. pallidum

mBio, 2018
Investigation of Treponema pallidum subsp. pallidum, the spirochete that causes syphilis, has been hindered by an inability to culture the organism continuously in vitro despite more than a century of effort.
Diane G. Edmondson, Bo Hu, Steven J. Norris   +2 more
doaj   +2 more sources

Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751

mSphere, 2020
Treponema pallidum subsp. pallidum is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical manifestations.
Karen V. Lithgow, Brigette Church, Alloysius Gomez, Emily Tsao, Simon Houston, Leigh Anne Swayne, Caroline E. Cameron   +6 more
doaj   +2 more sources

Treponema Pallidum: A Forgotten Pathogen With Major Cardiovascular Consequence. [PDF]

JACC Case Rep
Natour SJ, Rabadia SV, Stefanko DP, Fishbein GA, Parikh RV, Hsu JJ.   +5 more
europepmc   +2 more sources

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner

Frontiers in Immunology, 2022
Background Previous studies have confirmed that the bacterium Treponema pallidum (TP) or its proteins provide signals to macrophages that induce an inflammatory response; however, little is known about the negative regulation of this macrophage-mediated ...
Zhijia Li, Muzhou Teng, Yi-Huei Jiang, Litian Zhang, Xi Luo, Yuhui Liao, Bin Yang   +6 more
semanticscholar   +1 more source

A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples

Nature Communications, 2022
The performance of commonly used assays for diagnosis of syphilis varies considerably depending on stage of infection and sample type. In response to the need for improved syphilis diagnostics, we develop assays that pair PCR pre-amplification of the ...
Wentao Chen, Hao Luo, Lihong Zeng, Yuying Pan, J. Parr, Yinbo Jiang, C. Cunningham, Kelly L. Hawley, J. Radolf, Wujian Ke, J. Ou, Jianjiang Yang, Bin Yang, Heping Zheng   +13 more
semanticscholar   +1 more source

Phagocytosis and avirulent Treponema pallidum. [PDF]

Sexually Transmitted Infections, 1972
N N Izzat, Daniel M. Musher, Kyung‐Whan Min   +2 more
openalex   +5 more sources

Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis

Nature Microbiology, 2021
Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp. pallidum, has an estimated 6.3 million cases worldwide per annum.
M. Beale, M. Marks, M. Cole, Min-Kuang Lee, R. Pitt, Christopher Ruis, E. Balla, T. Crucitti, M. Ewens, C. Fernández-Naval, A. Grankvist, M. Guiver, C. Kenyon, Rafil Khairullin, R. Kularatne, M. Arando, B. Molini, A. Obukhov, E. Page, F. Petrovay, C. Rietmeijer, Dominic Rowley, S. Shokoples, E. Smit, E. Sweeney, G. Taiaroa, J. Vera, C. Wennerås, D. Whiley, D. Williamson, G. Hughes, P. Naidu, M. Unemo, M. Krajden, S. Lukehart, M. Morshed, H. Fifer, N. Thomson   +37 more
semanticscholar   +1 more source