Results 21 to 30 of about 63,007 (294)

In Vitro Transformation and Selection of Treponema pallidum subsp. pallidum

Current Protocols, 2022
Although the isolation of Treponema pallidum subsp. pallidum (T. pallidum) from a syphilis patient dates to 1912, for the duration of the 20th century, this pathogen has remained an exceedingly difficult organism to study due to the lack of a system to ...
Amber Phan, E. Romeis, L. Tantalo, L. Giacani   +3 more
semanticscholar   +1 more source

Phylogeny and antibiotic resistance of Treponema pallidum subsp. pallidum [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
The species Treponema pallidum includes 4 subspecies. According to the bioinformatic analysis, the syphilis pathogen T. pallidum subsp. pallidum was probably separated from the causative agents of yaws, bejel, and pinta more than 800 years ago. Its entry
Nosov N.Yu., Obraztsova O.A., Katunin G.L., Plakhova K.I., Solomka V.S.   +4 more
doaj   +1 more source

In Vitro Cultivation of the Syphilis Spirochete Treponema pallidum

Current Protocols, 2021
For over a century, investigation of Treponema pallidum subsp. pallidum, the spiral‐shaped bacterium that causes syphilis, was hindered by an inability to culture the organism in vitro. A recent breakthrough has enabled continuous in vitro growth of this
D. Edmondson, S. Norris
semanticscholar   +1 more source

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

PLoS Neglected Tropical Diseases, 2021
In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency ...
N. Lieberman, Michelle J. Lin, H. Xie, L. Shrestha, Tien V. Nguyen, Meei-Li W Huang, Austin M Haynes, E. Romeis, Qianqiu Wang, Rui-Li Zhang, Cai-Xia Kou, G. Ciccarese, I. Dal Conte, M. Cusini, F. Drago, S. Nakayama, Ken-ichi Lee, M. Ohnishi, K. Konda, S. Vargas, Maria Eguiluz, C. Caceres, J. Klausner, O. Mitjà, A. Rompalo, F. Mulcahy, E. Hook, S. Lukehart, A. Casto, Pavitra Roychoudhury, F. DiMaio, L. Giacani, A. Greninger   +32 more
semanticscholar   +1 more source

Seroprevalence with epidemiological determinants of hepatitis C virus and Treponema pallidum infection in blood donors of a teaching hospital in southwest Punjab, India: A 5-year study

Journal of Family Medicine and Primary Care, 2023
Background: A high seroprevalence of various transfusion-transmitted infections (TTIs) in donated blood is the main safety concern, especially in low- and middle-income countries.
Nidhi Bansal, Anshul Gupta, Tanvir K. Sidhu, Ram Niwas Maharishi, Saurabh Gupta, Arnav K. Roychoudhury   +5 more
doaj   +1 more source

The prevalence and associated factors of among HIV-positive and HIV-negative individuals who attended voluntary counseling and testing center of St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: A cross-sectional study design

SAGE Open Medicine, 2020
Background: Treponema pallidum and HIV are among the most common public health problems in Ethiopia. These infections are interrelated. Treponema pallidum causes genital ulcer which enhances HIV transmission and complicates HIV by causing severe ulcer ...
Habtamu Weldesenbet, Daniel Asrat, Yimtubezinash Weldeamanuel   +2 more
doaj   +1 more source

Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine

Journal of Bacteriology, 2021
The unusual outer membrane (OM) of T. pallidum, the syphilis spirochete, is the ultrastructural basis for its well-recognized capacity for invasiveness, immune evasion, and persistence. In recent years, we have made considerable progress in identifying T.
Kelly L. Hawley, Jairo M. Montezuma-Rusca, K. Delgado, Navreet Singh, V. Uversky, M. Caimano, J. Radolf, A. Luthra   +7 more
semanticscholar   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Crescentic glomerulonephritis associated with syphilis: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated. Case presentation A 62-year-old Japanese male showed edema,
Akiko Kaiga, Yuka Sato, Haruna Arakawa, Tatemitsu Rai, Akihiro Tojo   +4 more
doaj   +1 more source

Parameters Affecting Continuous In Vitro Culture of Treponema pallidum Strains

mBio, 2021
Syphilis is caused by the bacterium Treponema pallidum subsp. pallidum. Until recently, this pathogen could only be maintained through infection of rabbits or other animals, making study of this important human pathogen challenging and costly.
D. Edmondson, B. DeLay, Lindsay E. Kowis, S. Norris   +3 more
semanticscholar   +1 more source