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Frontiers in Microbiology, 2023 IntroductionSyphilis is a chronic, multi-stage infection caused by the extracellular bacterium Treponema pallidum ssp. pallidum. Treponema pallidum widely disseminates through the vasculature, crosses endothelial, blood–brain and placental barriers, and ...
Sean Waugh +10 more
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Mucopolysaccharidase of Treponema pallidum [PDF]
Infection and Immunity, 1979 Treponema pallidum (Nichols strain) exhibited mucopolysaccharidase activity. Acidic mucopolysaccharides were broken down more rapidly by viable treponemes than by heat-inactivated treponemes or membrane filtrates of treponemal suspensions.
T. J. Fitzgerald, Russell C. Johnson
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PLoS Neglected Tropical Diseases, 2021 Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK.
Michelle J. Lin +10 more
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Phylogenetic analysis of pbp genes in treponemes [PDF]
Infection Ecology & Epidemiology, 2013 Background: β-Lactamases are the main cause of bacterial resistance to penicillin, cephalosporins, and related β-lactam compounds. The presence of the novel penicillin-binding protein (pbp) Tp47 in Treponema pallidum has been reported to be
Tejpreet Chadha +1 more
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Frontiers in Microbiology, 2021 Treponema pallidum subspecies pallidum, the causative agent of syphilis, traverses the vascular endothelium to gain access to underlying tissue sites. Herein, we investigate the mechanisms associated with T.
K. Lithgow +5 more
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Notes on syphilis vaccine development
Frontiers in Immunology, 2022 The quest for a syphilis vaccine to provide protection from infection or disease began not long after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) strain in 1912.
Noah Kojima +3 more
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Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
Frontiers in Immunology, 2021 Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a major public health problem worldwide. Recent increases in the number of syphilis cases, in addition to the lack of an efficient vaccine against T.
Man Xu +7 more
semanticscholar +1 more source
Hybrid cell lines producing monoclonal antibodies directed against Treponema [PDF]
, 1985 Continuous hybrid cell lines for producing monoclonal antibodies directed against antigens of Treponema pallidum have been developed. The hybrid cell lines were established by fusing differentiated lymphoid cells primed with antigens of Treponema ...
Kettman, John R., Norgard, Michael V.
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, 2014 Yaws is a non-venereal endemic treponemal infection caused by Treponema pallidum sub-species pertenue, a spirochaete bacterium closely related to Treponema pallidum ssp. pallidum, the agent of venereal syphilis.
Higgins, Stephen P +3 more
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Universa Medicina, 2018 Background Syphilis is a multistage disease transmitted primarily through sexual intercourse. Nowadays, the polymerase chain reaction (PCR) test for Treponema pallidum has been widely used and is expected to overcome problems in diagnostic tests for ...
Ida Effendi +3 more
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