Results 41 to 50 of about 23,786 (209)

Expanded Functional Characterization and Optimization of Protein Expression in Treponema denticola Shuttle Plasmids

Molecular Oral Microbiology, EarlyView.
We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky, Valentina Godovikova, Prakaimuk Saraithong, Alexander H. Rickard, Brigette R. Crawley, Sara M. Agolli, Reagan L. Boyce, Trishna L. Appaji, J. Christopher Fenno   +8 more
wiley   +1 more source

THE TREPONEMA PALLIDUM [PDF]

Archives of Internal Medicine, 1909
The discovery by Schaudinn and Hoffmann 1 in 1905 of a spirillum in various luetic lesions marked the beginning of a decided advance in our knowledge of the etiology of syphilis. The announcement of the discovery, while most conservative in its assertions, gave a fresh impetus to the study of the many phases presented in the parasitology and pathology ...
openaire   +1 more source

Seroprevalence of the Hepatitis B, Hepatitis C, and Human Immunodeficiency Viruses and Treponema pallidum at the Beijing General Hospital from 2010 to 2014: A Cross-Sectional Study. [PDF]

PLoS ONE, 2015
The hepatitis B, hepatitis C, human immunodeficiency viruses and Treponema pallidum are important causes of infectious diseases concern to public health.Between 2010 and 2014, we used an automated chemiluminescence microparticle immunoassay to detect the
Shaoxia Xu, Qiaofeng Wang, Weihong Zhang, Zhifeng Qiu, Jingtao Cui, Wenjuan Yan, Anping Ni   +6 more
doaj   +1 more source

Quantified Detection of Treponema pallidum DNA by PCR Assays in Urine and Plasma of Syphilis Patients

Microbiology Spectrum, 2022
Treponema pallidum can invade any organ, and T. pallidum DNA can be detected in various tissues and fluids. However, the knowledge of the presence and loads of T. pallidum DNA in urine is limited.
Cuini Wang, Xin Zheng, Zhifang Guan, Danyang Zou, Xin Gu, Haikong Lu, Mei Shi, Pingyu Zhou   +7 more
doaj   +1 more source

Insight into the invasion process and immune-protective evaluation of Tp0971, a membrane lipoprotein from Treponema pallidum

Microbiology Spectrum, 2023
Treponema pallidum (T. pallidum), the pathogen of syphilis, can invade organisms through mucous membranes or broken skin and proliferate in the host. It spreads rapidly and causes chronic systemic multi-organ damage.
Xiaohong Zhang, Junxia Duan, Yali Wang, Bibo Xie, Jie Zhou, Sisi Zhao, Weiguo Yin, Peng Liu, Feijun Zhao   +8 more
doaj   +1 more source

Conjugal Secondary Syphilis With Divergent Cutaneous Manifestations: Papulonodular Variant

Clinical Case Reports, Volume 14, Issue 2, February 2026.
Secondary syphilis (Papulonodular variant). Multiple erythematous papules and nodules on the (a) left side of the neck, (b) posterior neck, and (c) face. (d) Solitary indurated, erythematous papule over the shaft of the penis (arrow). ABSTRACT Syphilis should be considered in patients with atypical papulonodular eruptions, as even conjugal cases may ...
Mahesh Mathur, Sumit Paudel, Sandhya Regmi, Nabita Bhattarai, Shilpa Maharjan, Sambidha Karki   +5 more
wiley   +1 more source

Establishment of Dementia Platform Korea and the Trial Ready Registry to advance Alzheimer's disease research in Korea

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract There is an abundance of high‐quality clinical data and resources for Alzheimer's disease (AD) in Korea. To investigate therapeutic targets and biomarkers, and to progress the AD research field in Korea by standardizing the dementia dataset in Korea, the Trial Ready Registry (TRR) and Dementia Platform Korea (DPK) were developed.
Haeng Jun Kim, Ki Woong Kim, Sang Won Seo, Jong‐Min Lee, Sun Jae Jung, Ji Won Han, Hyemin Jang, Jin Hyeong Jhoo, Jeong Lan Kim, Hee Won Yang, Eosu Kim, Il Han Choo, Seonggyu Kim, Kyeong Ho Kim, Jihyun Lee, Inhee Mook‐Jung, TRR research group   +16 more
wiley   +1 more source

The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains. [PDF]

PLoS ONE, 2016
Treponema pallidum subspecies pallidum is the causative agent of syphilis, a chronic, multistage, systemic infection that remains a major global health concern. The molecular mechanisms underlying T.
Michelle L Parker, Simon Houston, Charmaine Wetherell, Caroline E Cameron, Martin J Boulanger   +4 more
doaj   +1 more source

The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation

Birth Defects Research, Volume 118, Issue 1, January 2026.
ABSTRACT Background Adverse birth outcomes are important public health measures and account for a substantial public health burden. There is considerable diversity of these health endpoints, as well as in the many factors suspected or recognized to increase their risk.
Paul J. Villeneuve, Ann Aschengrau, Michelle L. Bell, Yang Cao, Mark Elwood, Guy Eslick, Shelley Harris, Leeka Kheifets, Babak Khoshnood, Robert Norman, Nelson Pace, Johan Reutfors, Jeremy M. Schraw, Jose R. Suarez‐Lopez, Gunnar Toft, R. Douglas Wilson, Christopher R. Kirman, Tyler Carneal, Sean M. Hays   +18 more
wiley   +1 more source

The molecular epidemiology of Treponema pallidum subspecies pallidum [PDF]

Sexual Health, 2015
Pathogens adapt and evolve in response to pressures exerted by host environments, leading to generation of genetically diverse variants. Treponema pallidum subspecies pallidum displays a substantial amount of interstrain diversity. These variants have been identified in various parts of the world, indicating transmission linkage between geographical ...
Daphne Y, Ma, Lorenzo, Giacani, Arturo, Centurión-Lara   +2 more
openaire   +2 more sources