Results 191 to 200 of about 106,975 (225)
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Neuronal TRH synthesis: Developmental and circadian TRH mRNA levels
Biochemical and Biophysical Research Communications, 1988Peptide biosynthesis within a neuron involves several steps occurring at the soma and during its travel to the nerve terminal, where it accumulates to be released under stimulatory conditions. We have measured hypothalamic TRH and TRH mRNA during ontogeny and circadian cycle and observed that TRH mRNA variations are more prominent than TRH ones. On the
L, Covarrubias +4 more
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Endocrinology, 1980
Chromatographic evidence for alternative pathways of TRH catabolism in the brain, involving either cleavage of the pGlu-His peptide bond or deamidation to form pGlu-His- Pro (TRH-OH), has been described. In the present study, RIAs for TRH and TRH-OH were used to determine if synthetic TRH is degraded by rodent brain tissue into TRH-OH and to evaluate ...
CHARLES H. EMERSON +3 more
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Chromatographic evidence for alternative pathways of TRH catabolism in the brain, involving either cleavage of the pGlu-His peptide bond or deamidation to form pGlu-His- Pro (TRH-OH), has been described. In the present study, RIAs for TRH and TRH-OH were used to determine if synthetic TRH is degraded by rodent brain tissue into TRH-OH and to evaluate ...
CHARLES H. EMERSON +3 more
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International Pharmacopsychiatry, 1977
Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the ...
J C, Pecknold, T A, Ban
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Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the ...
J C, Pecknold, T A, Ban
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Protirelin (TRH) in Depression
Archives of General Psychiatry, 1974Protirelin (formally known as thyrotrophin releasing hormone [TRH]) was evaluated as a treatment in depression in two independent investigations using a similar protocol. The latter was designed so that some patients received three 600μg intravenous injections of protirelin early in their course and others received them toward the end of their course ...
L E, Hollister +4 more
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Reviews in Endocrine and Metabolic Disorders, 2016
The activity of the hypothalamus-pituitary-thyroid axis (HPT) is coordinated by hypophysiotropic thyrotropin releasing hormone (TRH) neurons present in the paraventricular nucleus of the hypothalamus. Hypophysiotropic TRH neurons act as energy sensors. TRH controls the synthesis and release of thyrotropin, which activates the synthesis and secretion of
Patricia Joseph-Bravo +2 more
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The activity of the hypothalamus-pituitary-thyroid axis (HPT) is coordinated by hypophysiotropic thyrotropin releasing hormone (TRH) neurons present in the paraventricular nucleus of the hypothalamus. Hypophysiotropic TRH neurons act as energy sensors. TRH controls the synthesis and release of thyrotropin, which activates the synthesis and secretion of
Patricia Joseph-Bravo +2 more
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Pharmacopsychiatry, 2022
AbstractThyrotropin-releasing hormone (TRH), at doses lower than those needed to stimulate prolactin secretion directly, can almost completely antagonize dopamine inhibition of prolactin release. In normal men, prolactin increases 15 min following an i. v. bolus of 12.5 µg TRH
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AbstractThyrotropin-releasing hormone (TRH), at doses lower than those needed to stimulate prolactin secretion directly, can almost completely antagonize dopamine inhibition of prolactin release. In normal men, prolactin increases 15 min following an i. v. bolus of 12.5 µg TRH
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Archives of Internal Medicine, 1984
The isolation of thyrotropin-releasing hormone (TRH, protirelin) in 1969 1,2 allowed an initial definition of specific biochemical mechanisms by which the brain regulates the release of pituitary hormones. The neuroendocrine role of TRH (initiating the pituitary release of thyrotropin) still remains as the best resolved physiologic function of this ...
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The isolation of thyrotropin-releasing hormone (TRH, protirelin) in 1969 1,2 allowed an initial definition of specific biochemical mechanisms by which the brain regulates the release of pituitary hormones. The neuroendocrine role of TRH (initiating the pituitary release of thyrotropin) still remains as the best resolved physiologic function of this ...
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Norvaline2-TRH: binding to TRH receptors in rat brain homogenates
European Journal of Pharmacology, 1990Norvaline2-thyrotropin-releasing hormone ([Nva2]TRH) has been described as a thyrotropin-releasing hormone (TRH) analog with no thyrotropin (TSH)-releasing capacity but enhanced analeptic activity compared with TRH, as shown by the reversal of haloperidol-induced catalepsy.
S, Vonhof +3 more
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Enzymic formation of TRH-OH from TRH by rat hypothalamus
Molecular and Cellular Endocrinology, 1980Specific radioimmunoassays for thyrotrophin-releasing hormone (TRH) and deamido-TRH (TRH-OH) were used to investigate the inactivation of TRH by subcellular fractions from rat hypothalamus. TRH-OH was rapidly formed from TRH by an amidase present only in the supernatant fraction at an optimum pH of 7.38; although TRH was degraded by the particulate ...
E C, Griffiths +3 more
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General and Comparative Endocrinology, 1984
The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhibiting marked regional differences ...
D R, Burt, M A, Ajah
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The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhibiting marked regional differences ...
D R, Burt, M A, Ajah
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