Results 31 to 40 of about 23,921 (208)

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

Triple-dose bolus versus continuous infusion of tranexamic acid: impacts on clinical outcomes in isolated coronary artery bypass surgery

Journal of Cardiothoracic Surgery
Background In cardiac surgery, intraoperative tranexamic acid (TXA) is commonly used and highly recommended approach for managing perioperative bleeding. Nevertheless, a standardized dose and administration protocol remains undefined. This study compares
Osman Uzundere, Mahmut Yargı, Selen Topalel, Ahmet Serkan Aydın, Meral Erdal Erbatur, Hülya Tosun Söner, Reşit Saruhan, Cem Kıvılcım Kaçar, Erhan Gökçek   +8 more
doaj   +1 more source

Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning

Frontiers in Cellular Neuroscience, 2018
Thyrotropin-releasing hormone (TRH) regulates various physiological activities through activation of receptors expressed in a broad range of cells in the central nervous system.
Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai, Hirokazu Hirai   +6 more
doaj   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

[β-Glu2]TRH Is a Functional Antagonist of Thyrotropin-Releasing Hormone (TRH) in the Rodent Brain

, 2021
Selective antagonists of thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2), in order to enable a better understanding of this peptide’s central functions, have not been identified.
Vien Nguyen, Katalin Prokai-Tatrai, Nguyen, Vien, Prokai, Laszlo, Prokai-Tatrai, Katalin, Laszlo Prokai   +5 more
core   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Inspiratory-Activated Airway Vagal Preganglionic Neurones Excited by Thyrotropin-Releasing Hormone via Multiple Mechanisms in Neonatal Rats

Frontiers in Physiology, 2018
The airway vagal preganglionic neurons (AVPNs) providing projections to intrinsic tracheobronchial ganglia are considered to be crucial to modulation of airway resistance in physiological and pathological states.
Lili Hou, Lili Hou, Lili Hou, Min Zhang, Xingyi Zhang, Zhenwei Liu, Pengyu Zhang, Dongying Qiu, Dongying Qiu, Dongying Qiu, Lei Zhu, Xin Zhou   +11 more
doaj   +1 more source

Longitudinal Study of Total and Pathogenic Vibrio parahaemolyticus (tdh+ and/or trh+) in Two Natural Extraction Areas of Mytilus chilensis in Southern Chile

Frontiers in Microbiology, 2021
Vibrio parahaemolyticus is the leading cause of seafood-associated bacterial gastroenteritis worldwide. Although different studies have focused on its pattern of variation over time, knowledge about the environmental factors driving the dynamics of this ...
Cristina Bacian, Cristina Bacian, Cristobal Verdugo, Katherine García, Josu Perez-Larruscain, Ignacio de Blas, Viviana Cachicas, Carmen Lopez-Joven   +7 more
doaj   +1 more source

Reversible Exfoliation‐Aggregation Dynamics in Ionic COFs for Tunable Interfacial Catalysis

Advanced Science, EarlyView.
A unique ionic covalent organic framework (I‐4) exhibits unprecedented concentration‐dependent dynamic behavior in water, undergoing reversible transitions between aggregation and exfoliation. This enables fully controllable, bidirectional modulation of its particle size and surface micro‐environment.
Jilu Yang, Xiaofei Zhang, Yue Li, Yuping Cao, Zhaowei Jia, Bo Li, Haitao Feng, Xiaoqiang Cui, Wenwu Qin   +8 more
wiley   +1 more source

HYPOTHALAMIC NEUROHORMONES AND IMMUNE RESPONSES

Frontiers in Integrative Neuroscience, 2013
The aim of this review is to provide a comprehensive examination of the current literature describing the neural-immune interactions, with emphasis on the most recent findings of the effects of neurohormones on immune system.
J. Luis eQuintanar, Irene eGuzmán-Soto
doaj   +1 more source