Results 51 to 60 of about 12,599 (218)
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley +1 more source
Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries
Frontiers in Endocrinology, 2019 Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez +6 more
doaj +1 more source
Pituitary Thyrotropin-Releasing Hormone (TRH) Receptors: Effects of TRH, Drugs Mimicking TRH Action, and Chlordiazepoxide [PDF]
Molecular Endocrinology, 1989 Binding of TRH to specific cell surface receptors on clonal GH4C1 cells is followed within 10 min by receptor sequestration and over 24 h by receptor down-regulation. These experiments were designed to determine if TRH-activated second messenger systems are responsible for changes in receptor localization or number. BAY K8644 and A23187, which increase
P M, Hinkle, E D, Shanshala
openaire +2 more sources
Arthroscopy Techniques, EarlyView.Abstract Isolated avulsions of the distal biceps femoris are infrequent; however, they often occur in combination with other injuries to the posterolateral corner of the knee including the lateral collateral ligament (LCL). We describe a technique for LCL reconstruction with semitendinosus allograft through a bone tunnel in the fibula, followed by ...
Jason Long +5 more
wiley +1 more source
Considerations in evaluating the thyroid gland in a primary care setting
Journal of Family Medicine and Primary Care, 2020 The evaluation of the thyroid can be a very involved process. A misinterpretation of the results of a thyroid function test can lead to serious complexities in a patient's management and outcome.
Jose Humphreys
doaj +1 more source
Sleep in Young Children With Autism, ADHD and Combined Presentations
Autism Research, EarlyView.ABSTRACT Autism and attention deficit hyperactivity disorder (ADHD) are often accompanied by sleep problems. Longitudinal studies hint towards a greater proportion of persisting sleep problems across early development in neurodivergent compared to neurotypical individuals. Within the context of a prospective infant sibling study of autism and ADHD (n =
Eva‐Maria Kurz +2 more
wiley +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Reaching global net‐zero targets has become an urgent priority as businesses and nations face increasing pressure to reduce greenhouse gas emissions. Achieving carbon neutrality in manufacturing supply chains requires comprehensive systemic changes across business processes.
Vimal K. E. K. +5 more
wiley +1 more source
CellsThe amplitude of the phasic output of thyrotropin-releasing hormone (TRH) into the hypothalamus–pituitary portal capillaries is likely controlled by the TRH-degrading ectoenzyme (TRH-DE) expressed on the surface of median eminence (ME) β2-tanycytes.
Adair Rodríguez-Rodríguez +4 more
doaj +1 more source
Fit to Perfection? How Regulatory Fit Affects Consumer Adoption of Innovations
Journal of Consumer Behaviour, EarlyView.ABSTRACT Understanding how regulatory focus shapes consumer responses is critical to explaining innovation adoption. Existing research has primarily examined chronic regulatory focus, product message‐related regulatory focus, and temporary regulatory focus in isolation, thereby neglecting their interplay and the role of regulatory fit in shaping ...
Slawka Jordanow +3 more
wiley +1 more source