Results 61 to 70 of about 23,921 (208)

Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries

Frontiers in Endocrinology, 2019
Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez, Iván Lazcano, Edith Sánchez-Jaramillo, Rosa María Uribe, Lorraine Jaimes-Hoy, Patricia Joseph-Bravo, Jean-Louis Charli   +6 more
doaj   +1 more source

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy

Epilepsia, EarlyView.
Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger, Xinbing Zhang, Thomas Lisko, Hafsa Farooqi, Steffen Ventz, Sandipan Pati, Thomas R. Henry, David P. Darrow, Michael C. Park, Theoden I. Netoff, Robert A. McGovern   +10 more
wiley   +1 more source

Considerations in evaluating the thyroid gland in a primary care setting

Journal of Family Medicine and Primary Care, 2020
The evaluation of the thyroid can be a very involved process. A misinterpretation of the results of a thyroid function test can lead to serious complexities in a patient's management and outcome.
Jose Humphreys
doaj   +1 more source

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia, Akash Bera, Omar Mamad, James D. Mills, Benjamin Villasana‐Salazar, Giada Lavigna, Edoardo Micotti, Manuela Conticello, Asmin Alam, Roberto Chiesa, Francesca Pagani, Roberta Frapolli, Angelo M. Lavecchia, Christodoulos Xinaris, Eleonora Aronica, Andre Altmann, Teresa Ravizza, Sanjay M. Sisodiya, David C. Henshall, Annamaria Vezzani   +19 more
wiley   +1 more source

Zavedení značky na trh

, 2008
Práce popisuje teorii zavedení značky na zahraniční trh. Charakterizuje specifika trhu s vlasovou kosmetikou a podrobně se věnuje vstupu na český trh s vlasovou kosmetikou formou smlouvy o výhradní distribuci. Příkladem z praxe je postup zavedení italské
Kahánková, Tereza
core   +2 more sources

Structural morphometry distinguishes vagus nerve stimulation outcomes in individuals with epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Vagus nerve stimulation (VNS) is a commonly used treatment for drug‐resistant epilepsy. However, response to VNS is variable, while understanding of this response variability is limited. The vagus afferent network (VagAN), the neural circuits thought to be involved in response to vagal afferents, has been implicated in response ...
Harry J. Clifford, Sonja Fenske, Yujiang Wang, Tiago da Silva Costa, Rhys H. Thomas, Sabahat Iqbal, Cameron A. Elliott, Davide Giampiccolo, John S. Duncan, Peter N. Taylor   +9 more
wiley   +1 more source

Hypothalamic Median Eminence Thyrotropin-Releasing Hormone-Degrading Ectoenzyme Activity Is Dispensable for Basal Thyroid Axis Activity in Lean Rodents

Cells
The amplitude of the phasic output of thyrotropin-releasing hormone (TRH) into the hypothalamus–pituitary portal capillaries is likely controlled by the TRH-degrading ectoenzyme (TRH-DE) expressed on the surface of median eminence (ME) β2-tanycytes.
Adair Rodríguez-Rodríguez, Rosa María Uribe, Antonieta Cote-Vélez, Patricia Joseph-Bravo, Jean-Louis Charli   +4 more
doaj   +1 more source

Pituitary Thyrotropin-Releasing Hormone (TRH) Receptors: Effects of TRH, Drugs Mimicking TRH Action, and Chlordiazepoxide [PDF]

Molecular Endocrinology, 1989
Binding of TRH to specific cell surface receptors on clonal GH4C1 cells is followed within 10 min by receptor sequestration and over 24 h by receptor down-regulation. These experiments were designed to determine if TRH-activated second messenger systems are responsible for changes in receptor localization or number. BAY K8644 and A23187, which increase
P M, Hinkle, E D, Shanshala
openaire   +2 more sources

Répression transcriptionnelle du gène TRH [PDF]

, 2005
Les hormones thyroïdiennes (HT : T3, T4) exerçant des effets pléiotropes chez les vertébrés, leur synthèse et leur sécrétion doivent être finement contrôlées.
Dupré, Sandrine M., Hajer Guissouma, Sandrine M. Dupré, Demeneix, Barbara A., Barbara A. Demeneix, Guissouma, Hajer   +5 more
core   +1 more source

DECREASE study: A European pool‐analysis of patients with significant reductions in concomitant antiseizure medications in cenobamate Early Access Programs

Epilepsia Open, EarlyView.
Abstract Objective To evaluate the effectiveness and tolerability of cenobamate in patients with a significant reduction in concomitant antiseizure medication (ASM) in European cenobamate Early Access Programs (EAPs). Method Anonymized patient data from real‐world studies/registries associated with European cenobamate EAPs were pooled.
Vicente Villanueva, Simona Lattanzi, Javier Peña‐Ceballos, Rhys H. Thomas, Juan Rodríguez‐Uranga, Zsófia Jordán, Bernhard J. Steinhoff, Randi von Wrede, Norman Delanty, Patrick B. Moloney, Roberta Roberti, Giovanni Boero, Laura Canafoglia, Nicola Specchio, Antonio Gambardella, Edoardo Ferlazzo, Francesca Felicia Operto, Elena Tartara, Hester Garratt, Dániel Fabó, Asier Gómez‐Ibáñez, Gustavo Torres‐Gaona, Yulia Novitskaya, Rainer Surges, Kevin Hampel, Andreas Schulze‐Bonhage   +25 more
wiley   +1 more source