Results 81 to 90 of about 12,599 (218)

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Budesonide and Surfactant Therapy Versus Surfactant Alone on Incidence of Lung Disease in Preterm Infants (BEST Lung): Study Protocol for a Systematic Review and Individual Participant Data Meta‐Analysis With Nested Prospective Meta‐Analysis

Acta Paediatrica, EarlyView.
ABSTRACT Introduction Bronchopulmonary dysplasia (BPD) is a leading cause of morbidity and mortality in preterm infants. Combining surfactant with budesonide has been proposed to prevent BPD, but results from existing randomised controlled trials (RCTs) are conflicting.
James X. Sotiropoulos, Brett J. Manley, Sol Libesman, Namasivayam Ambalavanan, Abhik Das, Christopher J. D. Mckinlay, Nalinikanta Panigrahy, Melinda Cruz, David Nguyen, Jonathan Williams, Peter Davis, Kylie E. Hunter, Anna Lene Seidler   +12 more
wiley   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

It Is Because of Our Society, but Inside the Child: Ambiguity in Dutch Youth Health Care Professionals' Understanding of Normalisation

Children &Society, EarlyView.
ABSTRACT In response to the rising number of children in youth care in the Netherlands, the Dutch Youth Act calls for normalisation, de‐medicalisation and unburdening. The present study investigated the views of physicians and nurses working in youth healthcare on the concept of normalisation.
Eva L. van Dijk, Sanne te Meerman, Ernst D. Thoutenhoofd, Albert W. Wienen, Donald G. van Tol, Tessa Overmars‐Marx, Els Evenboer, Laura Batstra   +7 more
wiley   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

Cell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang, Xiaoyu Guan, Xiangrui Zhu, Yingying Hao, Ya Xu, Hao Yuan, Danni Gao, Hongxia Du, Jiayu Li, Weiwei Cao, Cui Ma, Xiaoying Wang   +11 more
wiley   +1 more source

Minor neurological dysfunction in children with developmental coordination disorder

Developmental Medicine &Child Neurology, EarlyView.
Aim To provide insight into the prevalence and types of minor neurological dysfunction (MND) in subtypes of children with developmental coordination disorder (DCD) and in relation to behavioural‐emotional problems. Method A retrospective medical record study was conducted.
Marina M. Schoemaker, Jessica M. Lust, Anke Verhaegh, Ankie Diepstraten, Peter H. Wilson, Mijna Hadders‐Algra, Bert Steenbergen   +6 more
wiley   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

The FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

A multicentre evaluation of cardiovascular risk prediction tools in people living with HIV across England (ECARTH study)

HIV Medicine, EarlyView.
Abstract Introduction It remains unclear which cardiovascular disease (CVD) risk scores are optimized for people living with treated HIV with high rates of viral suppression. We evaluated the performance of commonly used CVD risk scores in a population of primarily well‐treated HIV patients in England.
Ming Jie Lee, Ashley Murray, Colette Smith, Zakee Abdi, Alastair Duncan, Ellen Dwyer, Mark Gompels, Merle Henderson, Margaret Johnson, Frances Lander, Gavin Manmathan, Jonathan Mok, Nnenna Ngwu, Coral Pratt, Iain Reeves, Razan Saman, Alice Sharp, Eleanor Taylor, Jhia Jiat Teh, Richard Stevens, Thomas R. Fanshawe, Jienchi Dorward, Ranjababu Kulasegaram, Anthony S. Wierzbicki   +23 more
wiley   +1 more source

Kapitálový trh a perspektívy jeho ďalšieho vývoja

Časopis pro Právní Vědu a Praxi, 2006
Už od histórie sa ľudstvo stretáva s pojmom trh. Základem existencie trhového hospodárstva je trh, ktorý je predpokladom fungovania modernej ekonomi­ky. Trh je oblasťou ekonomiky, kde dochádza k výme­ne tovarov a služieb.
Jana Galajdová
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