Results 91 to 100 of about 36,954 (245)

Vibrio parahaemolyticus Strains of Pandemic Serotypes Identified from Clinical and Environmental Samples from Jiangsu, China

open access: yesFrontiers in Microbiology, 2016
Vibrio parahaemolyticus has emerged as a major foodborne pathogen in China, Japan, Thailand and other Asian countries. In this study, 72 strains of V. parahaemolyticus were isolated from clinical and environmental samples between 2006 and 2014 in Jiangsu,
Jingjiao eLi   +8 more
doaj   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly   +3 more
wiley   +1 more source

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

open access: yesIntegrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao   +8 more
wiley   +1 more source

Trajectories of medication for opioid use disorder and their impact on HIV testing among people who inject drugs in India: A longitudinal assessment of clinic‐based data

open access: yesAddiction, Volume 120, Issue 4, Page 745-755, April 2025.
Abstract Aims The aim of this study was to identify longitudinal trajectories of medication for opioid use disorder (MOUD) use throughout 1 year following MOUD initiation and to examine the association of trajectory membership with HIV testing among people who inject drugs in India.
Allison M. McFall   +8 more
wiley   +1 more source

Conformationally Restricted TRH Analogs:  The Compatibility of a 6,5-Bicyclic Lactam-Based Mimetic with Binding to TRH-R

open access: yes, 2016
A pair of conformationally restricted TRH analogs have been synthesized. Both analogs have the central histidine of TRH replaced by a cyclohexylalanine unit, and both analogs contain a 6,5-bicyclic lactam ring fusing the proline peptide bond into a trans
Wenhao Li (1424413)   +1 more
core   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

open access: yesBritish Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral   +3 more
wiley   +1 more source

Cerebrovascular effects of the TRH analogues pGlu-3-methyl-His-Pro amide and pGlu-Glu-Pro amide : a comparison with TRH.

open access: yes, 2000
The goal of the study was to assess whether TRH analogues possess cerebrovascular effects similar to the native peptide. The neuropeptide thyrotropin releasing hormone (TRH) elicits cerebrovasodilation in several species under various conditions.
Koskinen, Lars-Owe D.   +4 more
core   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

open access: yesCancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

De TRH-test tijdens de behandeling van schildklierziekten : dynamische veranderingen van de door TRH gestimuleerde TSH-afgifte

open access: yes, 1979
Na de opheldering van de structuurformule van het TRH, ongeveer gelijktijdig door Schally en door Guillemin en medewerkers in 1969, en na het beschikbaar komen van TRH in synthetische vorm, is het TRH veelvuldig toegepast bij de diagnostiek van ...
Fischer, H.R.A.
core   +1 more source

A Specific tRNA Half, 3'tiRNA‐GlyGCC, Regulates Hypoxic Pulmonary Artery Smooth Muscle Cell Proliferation via Myrf‐Mediated Endoplasmic Reticulum Stress

open access: yesCell Proliferation, EarlyView.
A schematic diagram illustrating how 3′tiRNA‐GlyGCC promotes the endoplasmic reticulum stress (ERS) and proliferation in hypoxic pulmonary artery smooth muscle cells (PASMCs) by inhibiting the expression of myelin regulatory factor (Myrf), ultimately leading to pulmonary hypertension (PH).
Lixin Zhang   +11 more
wiley   +1 more source

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