Tricarboxylic Acid Cycle Intermediates and Individual Ageing [PDF]
BiomoleculesAnti-ageing biology and medicine programmes are a focus of genetics, molecular biology, immunology, endocrinology, nutrition, and therapy. This paper discusses metabolic therapies aimed at prolonging longevity and/or health.
Natalia Kurhaluk
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Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer’s disease [PDF]
Frontiers in Neuroscience, 2023 Mitochondrial dysfunction, especially tricarboxylic acid (TCA) cycle arrest, is strongly associated with Alzheimer’s disease (AD), however, its systemic alterations in the central and peripheral of AD patients are not well defined.
Dongdong Jia +3 more
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Tracking the Reversed Oxidative Tricarboxylic Acid Cycle in Bacteria [PDF]
Bio-Protocol, 2022 Different pathways for autotrophic CO2 fixation can be recognized by the presence of genes for their specific key enzymes. On this basis, (meta)genomic, (meta)transcriptomic, or (meta)proteomic analysis enables the identification of the role of an ...
Lydia Steffens +4 more
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The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi [PDF]
Molecules, 2023 In fungi, the methylcitrate cycle converts cytotoxic propionyl-coenzyme A (CoA) to pyruvate, which enters gluconeogenesis. The glyoxylate cycle converts acetyl-CoA to succinate, which enters gluconeogenesis.
Zhicheng Huang +8 more
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The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy [PDF]
ResearchThe tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position, the TCA cycle remains ...
Jie Wu +7 more
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Succinyl-CoA:acetate CoA-transferase functioning in the oxidative tricarboxylic acid cycle in Desulfurella acetivorans [PDF]
Frontiers in Microbiology, 2022 Desulfurella acetivorans is a strictly anaerobic sulfur-reducing deltaproteobacterium that possesses a very dynamic metabolism with the ability to revert the citrate synthase version of the tricarboxylic acid (TCA) cycle for autotrophic growth (reversed ...
Eugenio Pettinato +2 more
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LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Triple-negative breast cancer is a complex breast malignancy subtype characterized by poor prognosis. The pursuit of effective therapeutic approaches for this subtype is considerably challenging.
Zihan Xi +10 more
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Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
Life, 2021 The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins.
Inseok Choi, Hyewon Son, Jea-Hyun Baek
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Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases
Biomolecules, 2021 Mitochondria are complex organelles that orchestrate several functions in the cell. The primary function recognized is energy production; however, other functions involve the communication with the rest of the cell through reactive oxygen species (ROS ...
Alexis Paulina Jiménez-Uribe +3 more
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Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines
Metabolites, 2021 Regular physical activity is an effective strategy to prevent and ameliorate aging-associated diseases. In particular, training increases muscle performance and improves whole-body metabolism.
Jennifer Maurer +2 more
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