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The History of the Tricarboxylic Acid Cycle
Perspectives in Biology and Medicine, 1970and vision? It was of course nothing ofthe kind, but a very slow evolu- tionary process, extending over some five years beginning (as far as I am involved) in 1932. At that time the problem of the intermediary stages ofthe pathways ofanaerobic energy metabolism—glycolysis and alcohol fermentation—had been established in outline by 1932, but knowledge ...
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2021
Tricarboxylic acid (TCA) cycle, also known as citric acid cycle and Krebs’ cycle, is the final step in complete oxidation of glucose under aerobic conditions. During aerobic respiration, pyruvate is oxidized to acetyl CoA by the action of the pyruvate dehydrogenase enzyme complex.
Rani Gupta, Namita Gupta
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Tricarboxylic acid (TCA) cycle, also known as citric acid cycle and Krebs’ cycle, is the final step in complete oxidation of glucose under aerobic conditions. During aerobic respiration, pyruvate is oxidized to acetyl CoA by the action of the pyruvate dehydrogenase enzyme complex.
Rani Gupta, Namita Gupta
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2011
Named for its metabolism of the conjugate bases (citrate, isocitrate, and cis-aconitate) of three tricarboxylic acids in the early steps of the pathway, the Tricarboxylic Acid Cycle (or TCA cycle) is known simply as the Citric Acid Cycle. The term “cycle” refers to the fact that the initial six-carbon substrate (citrate) is oxidatively decarboxylated ...
Herbert J. Fromm, Mark S. Hargrove
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Named for its metabolism of the conjugate bases (citrate, isocitrate, and cis-aconitate) of three tricarboxylic acids in the early steps of the pathway, the Tricarboxylic Acid Cycle (or TCA cycle) is known simply as the Citric Acid Cycle. The term “cycle” refers to the fact that the initial six-carbon substrate (citrate) is oxidatively decarboxylated ...
Herbert J. Fromm, Mark S. Hargrove
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1954
Publisher Summary This chapter discusses the tricarboxylic acid cycle in animal tissues microorganisms and plant material. Thetricarboxylicacid cycle was first proposed in 1937 under the name citric acid cycle to describe the intermediary stages of oxidation of carbohydrate in pigeon breast muscle.
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Publisher Summary This chapter discusses the tricarboxylic acid cycle in animal tissues microorganisms and plant material. Thetricarboxylicacid cycle was first proposed in 1937 under the name citric acid cycle to describe the intermediary stages of oxidation of carbohydrate in pigeon breast muscle.
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1998
Like all organic compounds, glucose will burn in air to produce carbon dioxide and heat. This oxidation process has been harnessed by living organisms not to produce heat, but to trap chemical energy in the form of ATP which can be used for a variety of cellular functions.
J. M. Chesworth +2 more
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Like all organic compounds, glucose will burn in air to produce carbon dioxide and heat. This oxidation process has been harnessed by living organisms not to produce heat, but to trap chemical energy in the form of ATP which can be used for a variety of cellular functions.
J. M. Chesworth +2 more
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Tricarboxylic Acid Cycle and Glyoxylate Bypass
EcoSal Plus, 2005The tricarboxylic acid (TCA) cycle plays two essential roles in metabolism. First, under aerobic conditions the cycle is responsible for the total oxidation of acetyl-CoA that is derived mainly from the pyruvate produced by glycolysis. Second, TCA cycle intermediates are required in the biosynthesis of several amino acids. Although the TCA
John E, Cronan, David, Laporte
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Rate parameters of the tricarboxylic acid cycle
Archives of Biochemistry and Biophysics, 1968Abstract Several aspects of the kinetic behavior of the tricarboxylic acid cycle in isolated mitochondria have been investigated. For this purpose rat heart mitochondria metabolizing pyruvate as the major substrate were incubated with succinate-1,4- 14 C (11μ m ) both in the presence and absence of added ADP.
F A, McElroy, G R, Williams
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Alternate Tricarboxylic Acid Cycle
2021TCA cycle is widely present among all heterotrophs growing aerobically. It operates throughout in the presence of oxygen. However, in some facultative microorganisms, it runs partially with activation of some new enzyme activities and also down-regulation of existing enzymes under anaerobic or microaerophilic conditions.
Rani Gupta, Namita Gupta
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Rate control of the tricarboxylic acid cycle
Advances in Enzyme Regulation, 1970Abstract The rate of the tricarboxylic acid cycle is determined by the first step, the citrate synthase reaction. The rate of this reaction depends on the concentrations of the two substrates (oxaloacetate and acetyl-CoA) and on the activity of citrate synthase. At mitochondrial concentrations of oxaloacetate the rate of the citrate synthase reaction
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1971
This chapter serves as a tiepoint to intermediate metabolism in the nervous tissue. Pyruvate is chosen as the starting point for this discussion in order to cover the interconversion of three-carbon and four-carbon acids. Consequently, the acetyl-coenzyme A (acetyl-CoA, AcCoA, CoAS~Ac) pathway which contributes a two-carbon element to citrate is also ...
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This chapter serves as a tiepoint to intermediate metabolism in the nervous tissue. Pyruvate is chosen as the starting point for this discussion in order to cover the interconversion of three-carbon and four-carbon acids. Consequently, the acetyl-coenzyme A (acetyl-CoA, AcCoA, CoAS~Ac) pathway which contributes a two-carbon element to citrate is also ...
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