Results 31 to 40 of about 73,690 (159)

Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells

mBio, 2019
Chronic bacterial infections are difficult to eradicate, though they are caused primarily by drug-susceptible pathogens. Antibiotic-tolerant persisters largely account for this paradox.
Eliza A. Zalis, Austin S. Nuxoll, Sylvie Manuse, Geremy Clair, Lauren C. Radlinski, Brian P. Conlon, Joshua Adkins, Kim Lewis   +7 more
doaj   +1 more source

Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism

Cell Reports, 2023
Summary: Lysine succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the tricarboxylic acid cycle.
Makayla S. Lancaster, Byungwook Kim, Emma H. Doud, Mason D. Tate, Ahmad D. Sharify, Hongyu Gao, Duojiao Chen, Ed Simpson, Patrick Gillespie, Xiaona Chu, Marcus J. Miller, Yue Wang, Yunlong Liu, Amber L. Mosley, Jungsu Kim, Brett H. Graham   +15 more
doaj   +1 more source

Ascorbic acid deficiency promotes metabolic remodeling and pulmonary fibrosis that leads to respiratory failure in Sod1 and Akr1a double-knockout mice

Redox Biology
We recently reported that mice with a double knockout (DKO) of Sod1 encoding superoxide dismutase 1 (SOD1) and Akr1a encoding aldehyde reductase survived more than one year when supplemented with ascorbic acid (Asc) (1.5 mg/ml in drinking water), and ...
Tsukasa Osaki, Takujiro Homma, Yuya Soma, Satoshi Miyata, Yumi Matsuda, Junichi Fujii   +5 more
doaj   +1 more source

The Tricarboxylic Acid Cycle in Nematode Parasites [PDF]

Nature, 1949
IN nematode parasites the anaerobic breakdown of glycogen to pyruvate and lactate with a consequent formation of adenosine triphosphate follows a course similar to that in vertebrate muscle1. Since it appears that aerobic mechanisms may play an important part in the metabolism of certain nematode parasites2, studies on the carbohydrate metabolism of ...
V, MASSEY, W P, ROGERS
openaire   +2 more sources

The Role of TCA Cycle Anaplerosis in Ketosis and Fatty Liver in Periparturient Dairy Cows

Animals, 2015
The transition to lactation period in dairy cattle is characterized by metabolic challenges, negative energy balance, and adipose tissue mobilization. Metabolism of mobilized adipose tissue is part of the adaptive response to negative energy balance in ...
Heather M. White
doaj   +1 more source

Tricarboxylic acid cycle and one-carbon metabolism pathways are important in Edwardsiella ictaluri virulence. [PDF]

PLoS ONE, 2013
Edwardsiella ictaluri is a Gram-negative facultative intracellular pathogen causing enteric septicemia of channel catfish (ESC). The disease causes considerable economic losses in the commercial catfish industry in the United States. Although antibiotics
Neeti Dahal, Hossam Abdelhamed, Jingjun Lu, Attila Karsi, Mark L Lawrence   +4 more
doaj   +1 more source

Taurine Regulates Mitochondrial Function During 7,12-Dimethyl Benz[a]anthracene Induced Experimental Mammary Carcinogenesis

Journal of Pharmacopuncture, 2015
Objectives: The present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and ...
Manickam Kalappan Vanitha, Kalpana Deepa Priya, Kuppusamy Baskaran, Kuppusamy Periyasamy, Dhravidamani Saravanan, Ramachandran Venkateswari, Balasundaram Revathi Mani, Aruldass Ilakkia, Sundaramoorthy Selvaraj, Rajendran Menaka, Mahendran Geetha, Nadarajah Rashanthy, Pandi Anandakumar, Dhanapal Sakthisekaran   +13 more
doaj   +1 more source

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Nature Communications, 2021
α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected
Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell   +17 more
doaj   +1 more source

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle

Cell Reports, 2015
New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials.
Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinás, Akhil B. Vaidya   +9 more
doaj   +1 more source

Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns

Cell Reports, 2019
Summary: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citrate, itaconate, and α ...
Saioa Márquez, José Javier Fernández, Cristina Mancebo, Carmen Herrero-Sánchez, Sara Alonso, Tito A. Sandoval, Macarena Rodríguez Prados, Juan R. Cubillos-Ruiz, Olimpio Montero, Nieves Fernández, Mariano Sánchez Crespo   +10 more
doaj   +1 more source