Results 41 to 50 of about 7,894 (140)

BKV Agnoprotein Interacts with α-Soluble N-Ethylmaleimide-Sensitive Fusion Attachment Protein, and Negatively Influences Transport of VSVG-EGFP [PDF]

, 2011
Background: The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid ...
Johannessen, M., Mona Johannessen, Walquist, Mari, Moens, Ugo, Walquist Mari, Spang Anne, Mari Walquist, Moens Ugo, Anne Spang, Gerits, N., Spang, Anne, Johannessen, Mona, Marte Dragset, Gerits Nancy, Johannessen Mona, Nancy Gerits, Ugo Moens, Dragset Marte, Walquist, M., Gerits, Nancy, Dragset, Marte Singsås, Dragset, M., Spang, A., Moens, U.   +23 more
core   +1 more source

Human polyomaviruses and cancer: an overview

Clinics, 2018
The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the
José Carlos Mann Prado, Telma Alves Monezi, Aline Teixeira Amorim, Vanesca Lino, Andressa Paladino, Enrique Boccardo   +5 more
doaj   +1 more source

Prevalence of DNA of fourteen human polyomaviruses determined in blood donors

Transfusion, Volume 59, Issue 12, Page 3689-3697, December 2019., 2019
Abstract BACKGROUND Human polyomaviruses (HPyVs), like herpesviruses, cause persistent infection in a large part of the population. In immunocompromised and elderly patients, PyVs cause severe diseases such as nephropathy (BK polyomavirus [BKPyV]), progressive multifocal leukoencephalopathy (JC polyomavirus [JCPyV]), and skin cancer (Merkel cell ...
Sergio Kamminga, Els van der Meijden, Caroline de Brouwer, Mariet Feltkamp, Hans Zaaijer   +4 more
wiley   +1 more source

Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches

Journal of Immunology Research, Volume 2013, Issue 1, 2013., 2013
JC and BK polyomaviruses were discovered over 40 years ago and have become increasingly prevalent causes of morbidity and mortality in a variety of distinct, immunocompromised patient cohorts. The recent discoveries of eight new members of the Polyomaviridae family that are capable of infecting humans suggest that there are more to be discovered and ...
Cillian F. De Gascun, Michael J. Carr, Mario Clerici   +2 more
wiley   +1 more source

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex‐1 ICP47 on MHC‐I and MHC‐II Expression

Journal of Immunology Research, Volume 2013, Issue 1, 2013., 2013
Background. Among human polyomaviruses, only BK virus (BKV) and JC virus (JCV) encode an agnoprotein upstream of VP1 on the viral late transcript. BKV agnoprotein is abundantly expressed late in the viral life cycle, but specific cellular and humoral immune responses are low or absent.
Michela Cioni, Christian Mittelholzer, Marion Wernli, Hans H. Hirsch, Rossana Cavallo   +4 more
wiley   +1 more source

Review on the Relationship between Human Polyomaviruses‐Associated Tumors and Host Immune System

Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012
The polyomaviruses are small DNA viruses that can establish latency in the human host. The name polyomavirus is derived from the Greek roots poly‐, which means “many,” and ‐oma, which means “tumours.” These viruses were originally isolated in mouse (mPyV) and in monkey (SV40).
Serena Delbue, Manola Comar, Pasquale Ferrante, Ludovica Segat   +3 more
wiley   +1 more source

The Human Polyomavirus Middle and Alternative T-Antigens; Thoughts on Roles and Relevance to Cancer

Frontiers in Microbiology, 2018
Approximately 15–20% of human cancer is related to infection, which renders them potentially preventable by antimicrobial or antiviral therapy. Human polyomaviruses (PyVs) are relevant in this regard, as illustrated by the involvement of Merkel cell ...
Els van der Meijden, Mariet Feltkamp
doaj   +1 more source

Human Polyomaviruses in Skin Diseases

Pathology Research International, Volume 2011, Issue 1, 2011., 2011
Polyomaviruses are a family of small, nonenveloped viruses with a circular double‐stranded DNA genome of ~5,000 base pairs protected by an icosahedral protein structure. So far, members of this family have been identified in birds and mammals. Until 2006, BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40) were the only polyomaviruses known to ...
Ugo Moens, Maria Ludvigsen, Marijke Van Ghelue, Gerardo Ferrara   +3 more
wiley   +1 more source

The Role of Viruses in Cellular Transformation and Cancer

Cancer Reports, Volume 8, Issue 2, February 2025.
ABSTRACT Background Viral infections are established contributors to oncogenesis, leading to significant public health challenges. This systematic review aims to synthesize current knowledge on the mechanisms of viral cellular transformation and their association with various cancers.
Donath Damian
wiley   +1 more source

Expression of toll‐like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma

APMIS, Volume 133, Issue 1, January 2025.
Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll‐like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities.
Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund‐Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström   +8 more
wiley   +1 more source