Results 81 to 90 of about 11,859 (255)

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula, Del Rio, Juan-Carlos, Ferrier, Laurent, Kolf-Clauw, Martine, Marin, Daniela E., Moreno, Carolina, Nougayrède, Jean-Philippe, Oswald, Isabelle P, Pinton, Philippe   +8 more
core   +2 more sources

T‐2 Toxin Exploits Gut‐Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
T‐2 toxin promotes the proliferation of intestinal S. saprophyticus and facilitates its translocation to the liver in piglets and mice. The translocated bacteria trigger autophagy in Kupffer cells and recruit monocytes to the liver through the nucleotide‐binding oligomerization domain 2 (NOD2) signaling pathway, alongside the M1 polarization of hepatic
Yuanyuan Zhu, Liu Xu, Fangrui Guo, Jianyu Qu, Xiangyan Liu, Qiurong Xu, Jie Sheng, Jiangping Wang, Xiaohong Xie, Ruimin Ren, Chuan Zhou, Sisi Yan, Shuiping Liu, Zhihang Yuan, Rongfang Li, Jing Wu, Jine Yi, Yulong Yin, Lixin Wen, Ji Wang   +19 more
wiley   +1 more source

Multitoxin analysis of trichothecenes, including NX toxins, in rice and wheat

Applied Food Research
Fusarium species biosynthesize trichothecenes that contaminate food and poses health risks. Among these, NX toxins produced by F. graminearum and F. culmorum, are structurally similar to deoxynivalenol (DON).
Vito D’Ascanio, Alessandro Annunziato, Daria Carella, Gerlinde Weisenberger, Antonia Susca, Miriam Haidukowski, Antonio Moretti   +6 more
doaj   +1 more source

Safety of UV‐treated oil from yellow mealworm (Tenebrio molitor larvae) as a novel food pursuant to Regulation (EU) 2015/2283

EFSA Journal, Volume 23, Issue 11, November 2025.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on UV‐treated oil from yellow mealworm (Tenebrio molitor larvae) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is produced from farmed T.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Francesca Marcon, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Morten Poulsen, Miguel Prieto Maradona, Alexandros Siskos, Henk van Loveren, Vânia Mendes, Ermolaos Ververis, Karen Ildico Hirsch‐Ernst   +30 more
wiley   +1 more source

Prevalent Human Gut Bacteria Hydrolyse and Metabolise Important Food-Derived Mycotoxins and Masked Mycotoxins

Toxins, 2020
Mycotoxins are important food contaminants that commonly co-occur with modified mycotoxins such as mycotoxin-glucosides in contaminated cereal grains. These masked mycotoxins are less toxic, but their breakdown and release of unconjugated mycotoxins has ...
Noshin Daud, Valerie Currie, Gary Duncan, Freda Farquharson, Tomoya Yoshinari, Petra Louis, Silvia W. Gratz   +6 more
doaj   +1 more source

Aphids transform and detoxify the mycotoxin deoxynivalenol via a type II biotransformation mechanism yet unknown in animals [PDF]

, 2016
Biotransformation of mycotoxins in animals comprises phase I and phase II metabolisation reactions. For the trichothecene deoxynivalenol (DON), several phase II biotransformation reactions have been described resulting in DON-glutathiones, DON ...
Arroyo Manzanares, Natalia, Audenaert, Kris, De Boevre, Marthe, De Saeger, Sarah, De Zutter, Nathalie, Haesaert, Geert, Smagghe, Guy, Van Poucke, Celien   +7 more
core   +3 more sources

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

The Medical Relevance of Fusarium spp.

Journal of Fungi, 2020
The most important medical relevance of Fusarium spp. is based on their phytopathogenic property, contributing to hunger and undernutrition in the world. A few Fusarium spp., such as F. oxysporum and F.
Herbert Hof
doaj   +1 more source

Trichothecenes: Occurrence and Toxicoses

Journal of Food Protection, 1978
The Δ9-12,13-epoxy-trichothecenes are a group of 37 naturally occurring sesquiterpenoids produced by species of Fusarium , Stachybotrys , Myrothecium , Trichoderma , and Cephalosporium . They are responsible for a variety of mycotoxicoses in man and animals that may be manifested by severe dermatitis, vomiting, bloody diarrhea, decreased weight gains ...
openaire   +2 more sources

Horizontal Gene Transfer in Plants and Implications for Biotechnology

Plant-Environment Interactions, Volume 6, Issue 5, October 2025.
ABSTRACT Horizontal gene transfer (HGT), a fundamental process long acknowledged in prokaryotic evolution, is increasingly recognized as a pivotal force in shaping the evolutionary trajectories of eukaryotes, including plants. Despite its established significance in prokaryotic adaptation, the role of HGT in eukaryotic evolution is still understudied ...
Rojana Binte Azad, Shamfin Hossain Kasfy, Kutubuddin Molla, Tofazzal Islam   +3 more
wiley   +1 more source