Clinical Experience on Switching Trientine Tetrahydrochloride to Trientine Dihydrochloride in Wilson Disease Patients [PDF]
JIMD ReportsThis study evaluates the effectiveness and safety of trientine dihydrochloride (TETA 2‐HCl) in patients with Wilson disease (WD) following a switch from trientine tetrahydrochloride (TETA 4‐HCl).
Isabelle Mohr +2 more
exaly +6 more sources
Pediatric Wilson Disease in Sudan: A Rare Case, Sudan Conflict and Diagnostic Challenges [PDF]
Clinical Case ReportsWilson disease is rarely reported among African children. Wilson disease is due to a mutation in ATP7B on an autosomal recessive pattern, which causes defective copper excretion and copper accumulation in tissues such as liver and brain.
Amjed Abdu Ali Mohammed +8 more
doaj +3 more sources
Safety of penicillamine and trientine in the treatment of Wilson's disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database. [PDF]
PLoS ONEBackgroundPenicillamine(D-Penicillamine) and trientine are first-line therapies for Wilson's Disease (WD), yet real-world data on their adverse events (AEs) remain scarce.
Wenlong Qian +12 more
doaj +3 more sources
Role of Trientine in Hypertrophic Cardiomyopathy: A Review of Mechanistic Aspects
Pharmaceuticals, 2022 Abnormality in myocardial copper homeostasis is believed to contribute to the development of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients with Wilson’s disease, demonstrates beneficial effects in patients with ...
Fitri Fareez Ramli +4 more
doaj +2 more sources
Exploring the Potential of Trientine Tetrahydrochloride in the Treatment of Wilson Disease
Health Sciences Review, 2023 Wilson disease is one of the uncommon, hereditary, slowly progressing, and autosomal recessive diseases that cause motion disorders. The pathogenesis of Wilson disease is attributed to the accumulation of copper in different parts of body mainly the ...
Pooja Chawla, Debashree Debasish Das
exaly +3 more sources
Post-marketing safety signals of Wilson’s disease therapies: evidence from FAERS and VigiBase [PDF]
Orphanet Journal of Rare DiseasesIntroduction Wilson’s disease is a rare autosomal copper metabolism recessive disorder that requires lifelong pharmacological treatment. D-penicillamine and trientine are the most commonly used copper chelators.
Hülya Tezel-Yalçın +3 more
doaj +2 more sources
The utility of whole exome sequencing in diagnosing Wilson disease: A case report. [PDF]
JPGN RepAbstract Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by mutations in the ATP7B gene, resulting in toxic copper accumulation in the body. Diagnosis is typically based on biochemistries, including low serum ceruloplasmin and elevated 24‐h urine copper excretion, with Kayser–Fleischer (KF) rings being a supportive ...
Palan MJ +4 more
europepmc +2 more sources
Trientine Hydrochloride (Waymade-Trientine)
Canadian Journal of Health Technologies, 2022 CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class. The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments ...
null Reimbursement Team
core +4 more sources
Comparative management practices of Wilson disease in Californian and Italian providers [PDF]
Journal of Health, Population and NutritionBackground There is a scarcity of randomized and high-quality studies to aid clinicians in management and treatment of Wilson disease (WD). Even amongst society practice guidelines in North America and Europe, diagnosis and management of WD varies.
Sandy Vien +4 more
doaj +2 more sources
Transition from zinc salts to trientine tetrahydrochloride in a cohort of adult patients with Wilson disease: the ZICUP study [PDF]
Orphanet Journal of Rare DiseasesWilson disease (WD) treatment aims to reduce copper accumulation in the liver and brain. Zinc salts (ZS) are often associated with gastrointestinal side effects, poor adherence, and reduced efficacy. Copper chelators, such as trientine tetrahydrochloride
Aurélia Poujois +5 more
doaj +2 more sources