Results 131 to 140 of about 22,737 (222)

Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity

, 2011
Toll-like receptor 4 (TLR4), which signals through the adapter molecules myeloid differentiation factor 88 (MyD88) and toll/interleukin 1 receptor domain-containing adapter inducing IFN-β (TRIF), is required for protection against Gram-negative bacteria.
Schesser, Kurt, Zaias, Julia, Becky Adkins, Masayuki Fukata, Siefker, David, Jose Ruiz, Andrea Echeverry, Kurt Schesser, Rebeca Santaolalla, David Siefker, Echeverry, Andrea, Julia Zaias, Adkins, Becky, Fukata, Masayuki, Norman Altman, Santaolalla, Rebeca, John Sotolongo, Cecilia España, Ruiz, Jose, Sotolongo, John, Altman, Norman, España, Cecilia   +21 more
core   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Determining the Bordetella LPS structural features that influence TLR4 downstream signaling

Frontiers in Microbiology
Upon recognizing bacterial lipopolysaccharide (LPS), human TLR4 initiates two distinct signaling pathways: the MyD88 pathway from the cell surface or the TRIF pathway following endocytosis.
Kiruthika Manivannan, Yasmine Fathy Mohamed, Yasmine Fathy Mohamed, Rachel C. Fernandez   +3 more
doaj   +1 more source

Direct and Element‐Mediated Edaphic Effects Shape Resource‐Conservative Leaf Trait Variation Across Serpentine and Limestone Soils

Ecological Research, Volume 41, Issue 5, September 2026.
Populations of closely related Epimedium taxa inhabiting serpentine and limestone soils converged toward resource‐conservative leaf trait syndromes despite strong differences in soil chemistry. Structural equation modeling revealed that edaphic variation was associated with leaf trait variation both directly and indirectly through shifts in leaf ...
Shogo Ueyama, Emi Kusatake, Makiko Mimura   +2 more
wiley   +1 more source

Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM

Innate immunity relies on Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns. The TIR (Toll/interleukin-1 receptor) domain-containing TLR adaptors TRIF (TIR domain–containing adaptor-inducing interferon-β) and TRAM (TRIF-related ...
Lee, MYL, Nanson, J., Vajjhala, P., Gu, W, Landsberg, M., Stacey, K., Kobe, B., Qian, X, Manik, MK, Gu, W., Xiao, L., Raunser, S., Ve, T, Pospich, S, Xiao, L, Wu, H., Landsberg, MJ, Stacey, KJ, Pan, M., Hedger, A, Raunser, S, Manik, M., Nanson, JD, Vajjhala, PR, Kim, H, Pan, M, Lee, M., Qian, X., Ve, T., Pospich, S., Kim, H., Hedger, A., et al.   +32 more
core   +1 more source

Caspase8 is required for the reduction of TRIF protein induced by NS4B.

, 2018
(A) HEK293T cells transfected with the plasmid expressing Flag-NS4B for 6 h were treated with DMSO control, chloroquine (20 μM) or Z-VAD-FMK (20 μM) for another 42 h, MG132 (5 μM) for 6 h.
Yisha Liang (5244368), Xuezhi Cao (5244365), Zhenliang He (5244371), Jin Zhong (9647), Qiang Ding (295913), Yanan Zhao (3132906)   +5 more
core   +1 more source

TIR Domain-Containing Adapter-Inducing Beta Interferon (TRIF) Mediates Immunological Memory against Bacterial Pathogens

, 2015
Induction of adaptive immunity leads to the establishment of immunological memory; however, how innate immunity regulates memory T cell function remains obscure.
Schesser, Kurt, Termini, J M, Romero, Laura, Claudia Flores, Laura Romero, Masayuki Fukata, Jose Ruiz, Kurt Schesser, Reldy Riveron, Saravana Kanagavelu, Fukata, Masayuki, Arditi, Moshe, Ruiz, Jose, Flores, Claudia, J. M. Termini, Moshe Arditi, Riveron, Reldy, Kanagavelu, Saravana   +17 more
core   +1 more source

TRIF as a Novel Modulator of Liver Inflammation and Fibrosis [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
openaire   +3 more sources

Aquamin, a marine derived multi-mineral, attenuates toll-like receptor-mediated inflammatory responses in macrophages. [PDF]

Front Immunol
Lioudakis E, Hans S, O'Gorman DM, O'Connell S, Lucitt M.   +4 more
europepmc   +1 more source

Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING. [PDF]

Immunity
Ragland SA, Lindblad KE, Li Y, Choi JH, Okin D, Mao JQ, Richmond-Buccola D, Coronado DR, Brown MR, Snapper SB, Kranzusch PJ, Kagan JC.   +11 more
europepmc   +1 more source