Results 121 to 130 of about 22,737 (222)
Advanced Science, Volume 13, Issue 51, 14 September 2026.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
Interaction of PLIC-1 and Trif.
, 2013 A. 2 µg YFP-PLIC1or GFP and 2 µg Flag-Trif were cotransfected into 293T cells at 70% confluence in a 60-mm plate. 48 hours post-transfection, cell lysates were prepared and subjected to M2 anti-Flag affinity resin. After extensive wash with PBS, proteins
Tapani Ronni (349649) +6 more
core +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang +13 more
wiley +1 more source
The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
Technology and research initiative fund (TRIF) annual report [PDF]
, 2002 The TRIF budget provides seed-funding and support for significant research projects at all three universities. The supported research includes projects in bioscience to improve health and projects in sustainability and renewable energy, including water ...
core
Ecology and Evolution, Volume 16, Issue 9, September 2026.Long‐legged Buzzard (Buteo rufinus) nests function as long‐term reservoirs of macroplastics, with plastic material persisting in nest structures and being transferred to other bird species through interspecific nest reuse. This persistence creates an overlooked pathway for the accumulation and spread of plastic pollution in terrestrial ecosystems, with
Emanuel‐Ștefan Baltag +4 more
wiley +1 more source
TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.
, 2010 The adapter protein TRIF mediates signal transduction through TLR3 and TLR4, inducing production of type I IFNs and inflammatory cytokines. The present study investigates the mechanisms by which TRIF signaling controls TNF-alpha biosynthesis.
Gais, P;Tiedje, C;Altmayr, F;Gaestel, M;Weighardt, H;Holzmann, B
core +1 more source
Natural Product‐Derived Vesicles in Nanotherapeutics
Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley +1 more source
The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.In a hyperglycemic and inflammatory microenvironment, keratinocytes and macrophages upregulate S100A8. This activates the TLR4/NF‐κB pathway, leading to increased pro‐inflammatory cytokines (IL‐1β, TNF‐α, and IL‐6), reduced antimicrobial peptides (AMPs), impaired keratinocyte migration/proliferation, and enhanced S.
Qi Wang +5 more
wiley +1 more source