Results 71 to 80 of about 22,737 (222)

Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling

Cells, 2023
Ethanol induces neuroinflammation, which is believed to contribute to the pathogenesis of alcohol use disorder (AUD). Toll-like receptors (TLRs) are a group of pattern recognition receptors (PRRs) expressed on both immune cells, including microglia and ...
Kalee N. Holloway, James C. Douglas, Tonya M. Rafferty, Cynthia J. M. Kane, Paul D. Drew   +4 more
doaj   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling [PDF]

, 2021
The TIR domain-containing adapter inducing IFN-β (TRIF) protein is an innate immune system protein that mediates the MyD88-independent toll-like receptor response pathway in mice and humans.
Loscher, Christine E., Webb, Andrew E, Kennedy, Kathy F., O'Connell, Mary J, Gerek Ince, Z. Nevin, Gerek Ince, Z Nevin, Loscher, Christine E, Hyland, Edel M; id_orcid, Hyland, Edel M., Webb, Andrew E., O'Connell, Mary J., Kennedy, Kathy F   +11 more
core   +1 more source

Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways

Vaccines, 2021
Porcine reproductive and respiratory syndrome virus (PRRSV) causes PRRS and is known to effectively suppress host innate immunity. The current strategies for controlling PRRSV are limited and complete understanding of anti-PRRSV innate immunity is needed.
Yulin Xu, Mengxue Ye, Youwen Zhang, Shaohua Sun, Jia Luo, Sen Jiang, Jiajia Zhang, Xueliang Liu, Qi Shao, Qi Cao, Wanglong Zheng, François Meurens, Nanhua Chen, Jianzhong Zhu   +13 more
doaj   +1 more source

Toll‐Like Receptors in the Mechanism of Hexabromocyclododecane‐Induced Production of Pro‐Inflammatory Cytokines

Journal of Applied Toxicology, EarlyView.
ABSTRACT Hexabromocyclododecane (HBCD), a brominated flame retardant, has raised increasing health concerns due to its bioaccumulation in human tissues and its ability to induce proinflammatory cytokines. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) are major mediators of inflammation, and their chronic elevation ...
Wenjun Zhu, Aleshia Seaton‐Terry, Brian Townsend, Zinia Hunter, April Falconer‐Turner, Syeda Raika Shahid, Margaret Whalen   +6 more
wiley   +1 more source

Trif-dependent induction of Th17 immunity by lung dendritic cells [PDF]

Mucosal Immunology, 2015
Allergic asthma is thought to stem largely from maladaptive T helper 2 (Th2) responses to inhaled allergens, which in turn lead to airway eosinophilia and airway hyperresponsiveness (AHR). However, many individuals with asthma have airway inflammation that is predominantly neutrophilic and resistant to treatment with inhaled glucocorticoids.
Hsia, Bethany J., Whitehead, Gregory S., Nakano, Keiko, Gowdy, Kymberly M., Thomas, Seddon Y., Aloor, Jim, Nakano, Hideki, Cook, Donald N.   +7 more
openaire   +2 more sources

Silence of TRIF facilitated EV71 infection in HT-29 cells.

, 2016
A. Knockdown of TRIF in HT-29 cells. Total RNA was extracted from HT-29-CTL and HT-29-TRIF cells. TRIF mRNA transcripts were measured by realtime RT-PCR with primers for TRIF (top).
Xinhui Yuan (2578156), Zheng Xing (335154), Yu Jin (360487), Lianfu Ji (2578153), Carol J. Cardona (137271), Chunyang Wang (500547)   +5 more
core   +1 more source

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

Frontiers in Immunology, 2022
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon
Allison M. Owen, Liming Luan, Katherine R. Burelbach, Margaret A. McBride, Cody L. Stothers, Olivia A. Boykin, Kalkena Sivanesam, Kalkena Sivanesam, Jessica F. Schaedel, Tazeen K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. Patil, Edward R. Sherwood, Edward R. Sherwood, Julia K. Bohannon, Julia K. Bohannon   +16 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

The role of TRIF protein in regulating the proliferation and antigen presentation ability of myeloid dendritic cells through the ERK1/2 signaling pathway in chronic low-grade inflammation of intestinal mucosa mediated by flagellin-TLR5 complex signal [PDF]

PeerJ
Objective The objective is to explore whether the flagellin-TLR5 complex signal can enhance the antigen presentation ability of myeloid DCs through the TRIF-ERK1/2 pathway, and the correlation between this pathway and intestinal mucosal inflammation ...
Zhaomeng Zhuang, Yi Chen, Juanhong Zheng, Shuo Chen   +3 more
doaj   +2 more sources