Results 91 to 100 of about 22,737 (222)
PLoS ONE, 2018 Type 1 diabetes (T1D) is caused by the autoimmune destruction of the insulin-producing pancreatic beta cells. While the role of adaptive immunity has been extensively studied, the role of innate immune responses and particularly of Toll- like Receptor ...
Ariadne Androulidaki +3 more
doaj +1 more source
British Journal of Industrial Relations, EarlyView.ABSTRACT In the 2000s, questions were open on whether the EU eastern enlargement would contribute to upwards or downwards convergence in labour standards, or even to divergence. Over two decades later, it is possible not only to attempt an answer, but also to identify the industrial relations processes that mediate economic integration between widely ...
Jon Erik Dølvik +3 more
wiley +1 more source
PLoS Pathogens, 2017 Toll-like receptor (TLR)-mediated signaling are critical for host defense against pathogen invasion. However, excessive responses would cause harmful damages to the host. Here we show that deficiency of the E3 ubiquitin ligase TRIM32 increases poly(I:C)-
Qing Yang +9 more
doaj +1 more source
Gender, Work &Organization, EarlyView.ABSTRACT Infertility predominantly affects people of working age, yet the experience of pursuing treatment while in employment rarely enters the workplace as a legitimate concern. Drawing on a longitudinal autoethnography of fertility treatment undertaken alongside an early academic career in Ireland between 2017 and 2024, and informed by policy, legal,
Valentina Paolucci
wiley +1 more source
Energy and inflation crises in Romania and Slovenia: different institutions, similar responses
The 2021–2022 inflation crisis in the EU offers an opportunity to examine how diverse industrial relations systems respond to similar macroeconomic shocks.
Guardiancich, Igor, Trif, Aurora
core +1 more source
, 2018 Binge/moderate alcohol suppresses TLR4–MyD88 proinflammatory cytokines; however, alcohol’s effects on TLR–TRIF signaling, especially after in vivo exposure in humans, are unclear. We performed a comparative analysis of the TLR4–MyD88, TLR4–TRIF, and TLR3–
Donna Catalano +3 more
core +1 more source
TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression
, 2014 Recent results indicate a significant contribution of innate immune signaling to maintain mucosal homeostasis, but the precise underlying signal transduction pathways are ill-defined.
Yang, I. +11 more
core +1 more source
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei.
PLoS ONE, 2008 BackgroundToll-like receptors (TLRs) have a central role in the recognition of pathogens and the initiation of the innate immune response. Myeloid differentiation primary-response gene 88 (MyD88) and TIR-domain-containing adaptor protein inducing IFNbeta
W Joost Wiersinga +3 more
doaj +1 more source
Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages
Frontiers in Immunology, 2018 Phenolic glycolipids (PGLs) are cell wall components of a subset of pathogenic mycobacteria, with immunomodulatory properties. Here, we show that in addition, PGLs exert antibactericidal activity by limiting the production of nitric oxide synthase (iNOS)
Reid Oldenburg +10 more
doaj +1 more source