Results 131 to 140 of about 216,734 (349)

The Impact of Triglyceride-Glucose Index Trajectories on Incidence and Recurrent Cardiovascular Events: Evidence from a Retrospective Cohort Study

Vascular Health and Risk Management
Yuan Xu,1,* Gonglong Wu,2,* Long Jiang,3 Xinlei Yang,1 Chengjin Wen,4 Yulan Yang,5 Hui Hu6 1Medical Big Data Center, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 2School of Public Health ...
Xu Y, Wu G, Jiang L, Yang X, Wen C, Yang Y, Hu H   +6 more
doaj  

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Evaluation of Triglyceride-Glucose (TyG) index in individuals living with HIV under antiretroviral therapy (ART)

BMC Infectious Diseases
Introduction Fasting triglyceride-glucose (TyG) index, which indirectly evaluates insulin resistance, is an important risk parameter in various diseases, especially cardiovascular diseases (CVD).
Bülent Kaya, Suzan Şahin, Serap Gençer   +2 more
doaj   +1 more source

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Association of Triglyceride–Glucose Index (TyG index) with HbA1c and Insulin Resistance in Type 2 Diabetes Mellitus

, 2021
Nachimuthu MAITHILI KARPAGA SELVI, Sivakumar NANDHINI, Varatharajan SAKTHIVADIVEL, Shanmugam LOKESH, Abu Raghavan SRINIVASAN, Saravanan SUMATHI   +5 more
openalex   +1 more source

The correlation of Triglyceride-glucose index with premature coronary heart disease and multivessel disease: a novel risk factor? [PDF]

, 2022
Ao Wei, Jingjing Liu, Le Wang, Senshuang Zheng, Hongliang Cong   +4 more
openalex   +1 more source

Hemoglobin glycation index and triglyceride-glucose index are related to diabetic nephropathy

Cirugía y Cirujanos (English Edition)
Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted.
openaire   +2 more sources

Association of triglyceride‑glucose index in branch retinal vein occlusion

Graefe's Archive for Clinical and Experimental Ophthalmology
Abstract Background To investigate the association between the triglyceride-glucose (TyG) index and newly diagnosed branch retinal vein occlusion (BRVO) in patients. Methods The study included 57 individuals with BRVO and a control group comprising 50 healthy volunteers ...
Hatice Aslan Sirakaya, Ender Sirakaya
openaire   +2 more sources

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source